Searchable abstracts of presentations at key conferences in endocrinology
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UKI NETS 15th National Conference

ea0052oc1 | (1) | UKINETS2017

A predictive quotient index, comprising neuroendocrine gene cluster analysis in blood and tissue grading is specifically predicts PRRT efficacy

Bodei Lisa , Kidd Mark , van der Zwaan Wouter , Singh Aviral , Severi Stefano , Drozdov Ignat , Kwekkeboom Dik , Cwikla Jaroslaw , Kolasinska-Cwikla Agnieska , Baum Richard P , Paganelli Giovanni , Krenning Eric , Modlin Irvin M

Background: The efficacy of PRRT is based upon NET over expression of somatostatin receptor (SSR) to deliver targeted isotope therapy. SSR expression (Krenning scale) compared to Predictive Quotient Index (PQI) (circulating NET transcript analysis mathematically integrated with grade) indicates the latter is more accurate for predicting PRRT efficacy. We evaluated whether PQI was specifically predictive or was prognostic for PRRT compared to other therapeutic strategi...

ea0052oc2 | (1) | UKINETS2017

Systematic evaluation of the immune microenvironment of neuroendocrine tumours

Vesely Clare , Childs Alexa , Wong Yien Ning Sophia , Ogunbiyi Olagunju , Gander Amir , Luong Tu Vinh , Thirlwell Chrissie , Caplin Martyn , Peggs Karl , Marafioti Teresa , Quezada Sergio A. , Meyer Tim

Background: Immunotherapy is currently being explored in many tumour types with encouraging results, but has not yet been evaluated in neuroendocrine tumours (NET). Our aim is to characterise the immune landscape of NET and determine which immune-modulatory pathways control the tumour infiltrating lymphocytes (TILs) in order to develop a rational approach for immunotherapy in this tumour type.Methods: Peripheral blood and fresh tissue was obtained from c...

ea0052oc3 | (1) | UKINETS2017

Incidence and prevalence of neuroendocrine tumours in England

Genus Tracey , Bouvier Catherine , Wong Kwok , Srirajaskanthan Rajaventhan , Rous Brian , Talbot Denis , Valle Juan , Khan Mohid , Pearce Neil , Elshafie Mona , Reed Nicholas , Luong Tu Vinh , Munir Alia , Ramage John

Introduction: Historically the incidence and prevalence of neuroendocrine tumours (NETs) has been difficult to establish due to issues with disease coding and data collection. Studies estimated the incidence of gastroenteropancreatic neuroendocrine tumours (GEP NETs) to be 1.3 per 100,000 per year (incidence hereafter given as cases per 100,000). However, the SEER USA data suggests a four-fold higher incidence, and prevalence of 35 per 100,000. This study aimed to identify the...