ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2017) 52 P34 | DOI: 10.1530/endoabs.52.P34

Grading systems in gastroenteropancreatic neuroendocrine tumours

Charlotte Hobby1, Meleri Morgan2, Aled Rees2, Mohid Khan2 & Adam Christian2


1Cardiff University, Cardiff, UK; 2University Hospital of Wales, Cardiff, UK.


Objective: To compare 3 methods of generating Ki-67% in gastroenteropancreatic neuroendocrine tumours (GEP-NETs).

Methods: Twenty-four slides were used to generate 49 images for analysis. Each image was analysed and 3 different methods were used to calculate Ki-67%.

Results: The comparison of Ki-67% from counting and estimating using the diameter (shortcut method) was strongly positively correlated, whereas the Ki-67% from counting and using ‘immunoratio’ were only weakly positively correlated.

Conclusion: Guidance from The Royal College of Pathologists 2017 states that clinicians must now count 2000 cells from hotspots within the tissue sample to calculate a Ki-67%. The shortcut method gives reasonably accurate results, the online ‘immunoratio’ is less reliable.

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