Endocrine Abstracts

Introduction: It is too much easier and cheaper to prevent a decrease a bone density and fractures, than in the future to treat osteoporosis and its complications.Materials and methods: We used an online system for patient education based on the video lessons to convey the necessary information on good nutrition, necessary to do exercises and the need for exposure to the sun. Also we added individual online doctors management.Study...

Background: In asthmatic patients, in addition to conventional risk factors for osteoporosis, inflammatory factors and treatment with corticosteroids may also lead them to further bone loss. The trabecular bone score (TBS) is a new indirect parameter of bone quality. There has been no study which evaluates TBS in asthmatic patients according to use of corticosteroids.Objective: This study evaluated the TBS according to the severity of asthma and the corr...

Background: This study examined the associations between diabetes (DM) and falls in Korean using data from a large population-based survey.Methods: This study analyzed 126 200 men and women (aged ≥50 years) who participated in Korean Community Health Survey in 2013. Logistic regression was used to assess the relationship between DM and falls.Results: The mean (±S.D.) of age, and body mass index was 64.9&#1...

Short bowel syndrome (SBS) is a complex disease, occurring after extensive resection of the small intestine, leading to malabsorption of nutrients and fluids. Lipids storage significantly affects bone maintenance. Caloric restriction promotes bone and adipose tissue (AT) loss but marrow adipose tissue (MAT) expansion. SBS is a condition strongly associated with malnutrition; patient survival initially depends of caloric replacement through parenteral nutrition (PN). The presen...

Objective: The study is aimed to estimate the effectiveness of kinesiotherapy based on deep core stability muscles training in the program of rehabilitation in patients with osteoporotic vertebral fractures (VF).Material and methods: Fourty-five patients (M-4, F-41) aged 43-81 (average age 62.75±12.5) with primary osteoporosis and at least one non-traumatic VF were included in the study. The rehabilitation program focused on training of deep core st...

Background: Bone marrow adipose tissue (BMAT) comprises >10% of total adipose mass in healthy humans and further increases in diverse clinical conditions, including obesity/diabetes, osteoporosis and following caloric restriction (CR). However, why BMAT increases during CR remains unknown. One possibility is that this is mediated by glucocorticoid (GC) excess. GC action on target tissues depends on circulating and intracellular concentrations of t...

Denosumab discontinuation (DD) induces an increase of B-crosslaps above baseline values for two years, and a decrease of BMD values. This rebound effect is associated with spontaneous clinical vertebral fractures (SCVF) in close to 15% of patients considering a follow-up of 2 years without taking another osteoporosis treatment. We report the clinical characteristics of 31 patients evaluated at our center from July 2015 to January 2018.Results: Thirty wom...

Introduction: Type 2 diabetes mellitus (T2DM) and osteoporosis may co-exist in the same individual. However, the exact effect of anti-osteoporotic treatment on glucose metabolism is unknown. We aimed to systematically review the effects of anti-osteoporotic medications on glucose metabolism and the incidence of T2DM.Methods/design: PubMed, Cochrane and EMBASE were systematically searched until the 31 of December, 2017.Results: ...

Bone mass, macrostructure and lean mass are being identified as main contributors of strength of upper femur. The purpose of this study has been to assess the role of the cortical and trabecular bone as well as muscle mass in the hip fracture production. We used a new DXA application which allow 3D bone volume reconstruction from standard 2D DXA scans, providing a three dimensional approach of the femoral shape and bone density spatial distribution and measurement cortical thi...

Introduction: Vitamin D (VD) deficiency affects many autoimmune disorders requiring steroid therapy. In contrast to glucocorticoid immune suppressive doses for autoimmune diseases, patients with Addison’s disease (AD) require physiological replacement. There is growing evidence of a cross-talk between glucocorticoids (GC) and VD. However, VD’s interaction with the GC pathway remains poorly understood.Methods: To explore this issue, CD14+</...