Endocrine Abstracts

Objective: Mounting evidence has shown an increased risk of gestational diabetes mellitus (GDM) in association with elevated exposure to air pollution. However, limited evidence is available concerning the effect of specific air pollutant(s) on GDM incidence.Methods: We conducted this case-control study on 6717 mothers with GDM diagnosed in 2006–2013 and 6717 age- and year of delivery-matched controls to further address the risk of GDM in relation t...

Aim: Gestational diabetes mellitus (GDM) is an important public health issue associated with significant short- and long-term morbidity both for mother and offspring. Prevalence rates of GDM show considerable variation among different countries and regions of the world. The primary aim of this study was to determine the nationwide prevalence and predictors of GDM in Turkey.Materials and methods: We conducted a prospective nationwide screening among pregn...

Aim of the study: To analyze the dynamics and levels of incretins and neuropeptides secretion in patients with CD and acromegaly and therefore to specify the pathogenesis of carbohydrate metabolism disturbances.Methods: Forty-two patients with Cushing disease and acromegaly were included into the study. All patients were newly diagnosed with Cushing disease and acromegaly. Oral glucose tolerance test (OGTT), during which glucose, glucagon, glucagon like ...

Objective: Although the importance of islet α-cell dysfunction in the pathogenesis of type 2 diabetes has been reappraised, data on whether increase or decrease of glucagon relative to insulin is related with glucose metabolism parameters or metabolic diseases such as nonalcoholic fatty liver disease(NAFLD) in clinical settings are very limited. Therefore, we investigated the association between glucagon-to-insulin ratio(G/I ratio) and presence of NAFLD and metabolic para...

The presence of type 1 diabetes (DM1) affects the heart rate variability (HRV). However, there are conflicting data on the impact of hyper- and hypoglycaemia on the parameters of cardiovascular autonomic regulation.The aim: To investigate the possible association of glucose fluctuation with HRV in longstanding DM1.Design and methods: We examined 49 patients with longstanding (>20 years) history of DM1 (without overt cardiovascu...

Objective: Neuroinflammation is a common primary or secondary mediator of the neurodegenerative process accompanying Alzheimer’s disease (AD). Impaired brain insulin signaling, defining brain insulin resistance may represent a link between AD and type 2 diabetes mellitus (T2DM) while neuronal apoptosis may also be involved in the inflammatory process. Peripheral cytokine levels of IL-1β, IL-6, TNFα along with high sensitivity C-reactive protein (hsCRP) and apopt...

Introduction: Gestational diabetes mellitus (GDM) is associated with an increase of maternal-fetal complications. Continuous glucose monitoring system (CGMS) detects postprandial hyperglycemia and hypoglycemia during 24h.Methods: Women with GDM in gestational weeks 26–32 were allocated a CGMS (IproTM2) after diagnosis in an observational prospective study. It was analysed: Mean glucose and standard deviation, area under the curve (AUC) wi...

Introduction: Elevated depressive symptoms and depressive disorders affect one in four patients with type 1 or type 2 diabetes (1). Thus, routine screening for depressive symptoms is indicated in this high-risk population. Current guidelines all recommend screening for depression in diabetic population(2). The Patient Health Questionnaire-9 (PHQ-9) is a valid screening tool for depression in individuals with diabetes (3). There is no specific data about the prevalence of depre...

Background: Celiac disease (CD) is an autoimmune enteropathy triggered by gluten ingestion in genetically susceptible individuals. Its prevalence is ~7 times higher in type 1 diabetes (T1D) patients compared to the general population; in addition to adherence to a gluten free (GF) diet, these patients use carbohydrate counting to estimate their pre-meal insulin dosages. We aimed to (a) compare the nutritional composition between some GF and non GF carbohydrate-rich products av...

Background: The aim of this study was to assess health-related quality of life (HRQoL) of patients living in cities and towns with different population in the Russian Federation (RF) using EQ-5D questionnaire, to calculate health utility index (QALY) and cost-utility ratio (CUR).Methods: One of the goals of the multicenter, observational, epidemiologic study FORSIGHT-DM2 was to evaluate HRQoL using the EQ-5D Questionnaire. The study included more than 20...

Background: Gestational diabetes mellitus (GDM) is associated with adverse perinatal outcomes, and increased risk of post-natal type 2 diabetes and cardiovascular disease. However, whether GDM increases the risk of developing incident Non-alcoholic Fatty Liver Disease (NAFLD) is unclear and has not been well examined in previous studies. This is important considering the significant health burden of NAFLD and the opportunity to interfere in high risk population in order to red...