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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

Guided Posters

Pituitary / Growth Hormone ' IGF Axis

ea0056gp184 | Pituitary / Growth Hormone ' IGF Axis | ECE2018

Adrenal insufficiency induced by anti-PD-1/anti-PD-L1 therapy in patients with cancer: a series of cases

Peiro I , Iglesias P , Simo-Servat A , Taberna M , Ruffineli JC , Guerrero F , Diez JJ , Villabona C

Background: Immune checkpoint inhibitors like monoclonal antibodies targeting programmed death 1 receptor (PD1) or its ligand (PD-L1) have shown antitumor activity in many malignancies by enhancing immune response against cancer cells resulting in significant long-lasting responses. However, this therapy can induce endocrine immune-related adverse events (EirAEs). Thyroid dysfunction is a common EirAE, while adrenal insufficiency (AI) is very uncommon.Ob...

ea0056gp185 | Pituitary / Growth Hormone ' IGF Axis | ECE2018

Long-term treatment with metyrapone in four patients with Cushing’s disease

Driessens Natacha , Maiter Dominique , Borensztein Pascale , Jaspart Amelie , Bostnavaron Martine , Beckers Albert

Introduction: Cushing’s disease (CD) is a severe disease, associated with an increased rate of comorbidities and mortality. Remission rate after surgery of pituitary tumor, is around 78%. Relapse occurs in 13% of patients within 10-years after surgery. According to guidelines, patients with unfeasible or non-curative surgery, require additional treatment, including medical therapies. Metyrapone, inhibits 11ß-hydroxylase enzyme, blocking the final step of cortisol syn...

ea0056gp186 | Pituitary / Growth Hormone ' IGF Axis | ECE2018

Primary posterior pituitary tumors: a unique neoplasm with hight morbidity

Guerrero Fernando , Vidal Noemi , Del Pozo Carlos , Blanco Concepcion , Rivero-Celada David , Diez Juan Jose , Iglesias Pedro , Pico Antonio , Villabona Carles

Background: The 2017 World Health Organization classification of pituitary tumors established that, pituicytoma, granular cell tumor of the sella (GCT) and spindle cell oncocytoma (SCO) are posterior pituitary tumors (PPT). These lesions are non-neuroendocrine and low-grade neoplasms of the sellar region presenting with mass effect symptoms. Their clinical manifestation, hormonal profile and radiological findings are indistinguishable from non-functioning pituitary adenomas (N...

ea0056gp187 | Pituitary / Growth Hormone ' IGF Axis | ECE2018

Erdheim-chester disease presenting with hypopituitarism and diabetes insipidus

Sugano Hisashi , Kitamura Wataru , Urata Tomoyuki , Okamoto Taku , Numoto Kunihiko , Maruyoshi Natsue

Introduction: Erdheim-Chester disease (ECD) is a rare and aggressive form of non-Langerhans cell histiocytosis (n-LCH). Its etiology is unknown, but recently, BRAFV600E (a proto-oncogene) has been found in more than 50% of cases. This may play a part in chronic uncontrolled inflammation, which is an important aspect of disease pathogenesis.Case report: A 42-year-old woman complained of generalized weakness, polyuria, and secondary amenorrhea. Biochemistr...

ea0056gp188 | Pituitary / Growth Hormone ' IGF Axis | ECE2018

Growth disorders in paediatric survivors of hematopoietic stem cell transplantation after chemotherapy-only conditioning- the experience of a single center

Cima Luminita-Nicoleta , Lambrescu Ioana Maria , Nedelea Lavinia , Sava Elisabeta , Leca Bianca , Vadana Elena-Alexandra , Colita Anca , Barbu Carmen Gabriela , Fica Simona

Objective: The reported incidence of growth disorders in hematopoietic stem cell transplantation (HSCT) recipients ranges from 20 to 80% and it was usually described in patients that were given total body irradiation (TBI) in the conditioning regimen. Because the effect of chemotherapy-only conditioning is less clear, we investigated the frequency of growth failure in our series of children treated with HSCT for different disorders without TBI as part of the conditioning proto...

ea0056gp189 | Pituitary / Growth Hormone ' IGF Axis | ECE2018

Association of IGF1 receptor autoantibodies with height and body size

Haudum Christoph , Minich Waldemar , Munzker Julia , Groselj-Strele Andrea , Kolesnik Ewald , Mursic Ines , Schwiebert Christian , Welsink Tim , Schmidt Albrecht , Pieber Thomas , Schomburg Lutz , Obermayer-Pietsch Barbara

Objective: Insulin-like growth factor 1 (IGF1) has a crucial role in growth and metabolism. A specifically designed autoantibody (aAb) assay against the IGF1 receptor (IGF1R-aAb) is able to detect IGF1R-aAb in serum. As the IGF1R has shown involvement in many functional pathologies (e.g. in the Laron syndrome), we aimed to investigate the role of IGF1R-aAb in a large population-based cohort of middle-aged volunteers and their potential effects on anthropometric, osteological a...

ea0056gp190 | Pituitary / Growth Hormone ' IGF Axis | ECE2018

Insulin sensitivity improves after disease control in acromegaly irrespective of treatment modality and despite an increase in intrahepatic lipid content: data from an investigator-initiated prospective trial

Arlien-Soborg Mai C , Dal Jakob , Madsen Michael , Hogild Morten , Jessen Niels , Jorgensen Jens Otto Lunde

Background: Active acromegaly induces insulin resistance despite a lean phenotype, both of which reverse by curative surgery. The impact of somatostatin analogue treatment on insulin sensitivity is less certain and may be offset by its anti-lipogenic effects.Aim: To study insulin sensitivity, body composition and extopic lipid content in newly diagnosed patients with acromegaly before and ≥6 months after successful surgical or medical treatment.</p...

ea0056gp191 | Pituitary / Growth Hormone ' IGF Axis | ECE2018

Ectopic Cushing’s syndrome secondary to medullary thyroid carcinoma with apparent signs of hypercortisolism: a case report

Canat M Masum , Cakir Sezin Dogan , Yildiz Duygu , Ozturk Feyza Yener , Erol Rumeysa Selvinaz , Sen Esra Cil , Saygili Emre Sedar , Basmaz Seda Erem , Batman Adnan , Altuntas Yuksel

Introduction: Ectopic ACTH syndrome (EAS) is a rare cause of Cushing’s syndrome. EAS is most frequently caused by bronchial carcinoid tumor or small cell lung cancer. Medullary thyroid carcinoma (MTC) is a rare source of EAS, as reported in this case.Case report: A 65-years-old-female with back pain and weight gain referred to our outpatient clinic with determined signs and symptoms of hypercortisolism. She had arterial hypertension, her sister had ...

ea0056gp192 | Pituitary / Growth Hormone ' IGF Axis | ECE2018

A case series of endocrine immune-related adverse effects of checkpoint inhibitors

Adamidou Fotini , Georgiou Thomas , Kafantari Katerina , Komzia Paraskevi , Vagionas Anastasios , Kita Marina

Background: With the increasing use of cancer immunotherapies in advanced solid organ and hematologic malignancies, endocrinologists are beckoned to manage endocrine complications with unique presentations and natural history in the already challenged oncology patient. We describe four patients illustrating the multifarious endocrine adversities of checkpoint inhibitors.Cases: Patient 1 is a 35-year old male with refractory Hodgkin’s lymphoma, previ...

ea0056gp193 | Pituitary / Growth Hormone ' IGF Axis | ECE2018

Hypophysitis due to immune checkpoint blockade: rising numbers.

van den Berg Gerrit , van den Brom Rob , van der Klauw Melanie , Hiltermann Jeroen , Hospers Geke , Links Thera

Hypophysitis is one of the immune-related adverse events of immune checkpoint blockade. This complication is potentially dangerous, mainly because of the insidious development of a life-threatening hypocortisolism. Unnecessary morbidity or mortality in an oncological responder may be the result. The number of patients treated with immune checkpoint inhibitors increases rapidly, due to the expansion of indications and trials. Moreover, the introduction of combination schedules ...