Searchable abstracts of presentations at key conferences in endocrinology
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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

ea0056mte1 | (1) | ECE2018

Using diabetes technologies to improve patient self care

Alcantara-Aragon Valeria

Diabetes technologies are evolving rapidly. They offer exciting opportunities to improve patient self-care but they may also be challenging for both patients and health-care providers. Thus, the use of technology may empower or burden. To understand and benefit from the use of these technologies we must first go beyond HbA1c, understand what truly matters to our patients, and what technology can provide in this setting. Available data on the use of technology including insulin...

ea0056mte2 | (1) | ECE2018

Acromegaly: Optimal management after surgery

Krsek Michal

Acromegaly is a rare condition caused by overproduction of growth hormone (GH). Early diagnosis, optimal treatment and follow-up is essential for prognosis of patients with acromegaly. Surgery is first choice treatment of acromegaly. Cure rates range around 80% (63–100%) in GH secreting microadenomas, however only about 50% (40–72) in macroadenomas. If not curable, surgery has to be followed by other treatment modalities to achieve treatment goals that are according ...

ea0056mte3 | (1) | ECE2018

Managing delayed puberty

Raivio Taneli

Delayed puberty (DP) is traditionally defined as the absence of testicular enlargement by the age of 14 years in boys and absence of breast development by 13 years in girls (1). In both sexes, DP is most frequently caused by constitutional delay of growth and puberty (CDGP), which represents a late variant of the normal timing of puberty (1-3). Other possible causes for DP include permanent hypogonadotropic hypogonadism (HH), functional hypogonadotropic hypogonadism and hyperg...

ea0056mte4 | (1) | ECE2018

Osteoporosis in men: management of bone health in the endocrine outpatient clinic

Vabderschueren Dirk

Several wrong conceptions persits with respect to male osteoporosis which unfortunately lead to under- diagnosis as well as under- treatment of this disease. Osteoporosis is still considered a female disorder. However, osteoporosis is not a rare condition especially in elderly and/or hypogonadal men. Moreover, fractures in elderly men are even more strongly associated with mortality than in women. Most of the risk factors for osteoporosis are also similar in men compared to wo...

ea0056mte5 | (1) | ECE2018

Medullary thyroid cancer beyond surgery

Maia Ana Luiza

Medullary thyroid carcinoma (MTC) is a rare thyroid C cell malignant tumor that accounts for 3-4% of thyroid gland neoplasias. MTC may occur sporadically or be inherited. Hereditary MTC appears as part of the MEN 2 syndrome. Germ-line mutations of the RET proto-oncogene cause hereditary cancer, whereas somatic mutations are frequently present in sporadic disease. Currently, early MTC diagnosis followed by total thyroidectomy offers the only possibility of the cure of the disea...

ea0056mte6 | (1) | ECE2018

Long-term implications of hypoglycaemia in diabetes Dr Ilhan Satman, Istanbul University, Turkey

Satman Ilhan

Hypoglycaemia is associated with considerable morbidity and even mortality in type 1, and less likely in type 2 diabetes. Generally, hypoglycaemia is accepted as a surrogate marker of poor health as it is likely to be more prevalent in renal and liver failures, which independently increase cardiovascular diasease (CVD) and neurocognitive risks. Hypoglycaemia, have been implicated with a fortunately rare but tragic event, ‘dead-in-bed’ syndrome. It has been hypothesis...

ea0056mte7 | (1) | ECE2018

Difficult cases of differentiated thyroid cancer

Mezosi Emese

The incidence of differentiated thyroid cancer (DTC) has increased worldwide which is mainly attributed to the more common detection of early stage DTC. The prognosis of early stage disease is excellent and the present ATA guidelines suggest less radical treatment and follow-up in these cases. TNM staging, risk classification, indication of radioiodine (RAI) treatment, evaluation of therapeutic response and TSH target range have been recently changed. However, 7–10% of DT...

ea0056mte8 | (1) | ECE2018

Hormone replacement for the travelling patient

Dusek Tina

Millions of people travel across time zones every day for business and for pleasure. Travel-related health issues arise from a variety of factors: infections, prolonged limited mobility during travel, and participation in certain activities, such as diving and high-altitude hiking during travel. Besides that, air travel allows individuals to traverse time zones faster than the internal clock, or circadian rhythm, can adjust. This results in desynchrony between the external lig...

ea0056mte9 | (1) | ECE2018

Premature ovarian insufficiency: an endocrine perspective

Vujovic Svetlana

Premature ovarian insufficiency (POI) is defined as hypergonadotropic oligo/amenorrhoea with FSH>40 IU/l, estradiol <50 pmol/l in women under 40 years of age. Biological aging is faster in this group of women inducing diseases and disturbing quality of life.Infertility in POI represents a special issue. Hypoestrogenism, hypoprogesteronism, hypoandrogenism, decreasing of dehydroepiandrosteron sulfate, growth hormone, and increasing insulin resistance influence all body ...

ea0056mte10 | (1) | ECE2018

The effect of gender-affirming therapy on bone in transgender persons

T'Sjoen Guy

Transgender persons on gender-affirming hormonal therapy will have experienced a hormonal reversal that will have had direct and also indirect effects on bone, through body composition changes. Recent evidence suggests that transgender women, even before the start of any hormonal intervention, already have a lower bone mass including a higher frequency of osteoporosis, and a smaller bone size vs. cisgender men. During gender-affirming hormonal treatment, bone mass is maintaine...

ea0056mte11 | (1) | ECE2018

How to integrate PCSK9 inhibitors into hyperlipidemia management

Georgescu Carmen

Anti-proprotein convertase subtilisin/kexin type 9 (PCSK9) monoclonal antibodies are a new class of biological drugs that inhibit binding of PCSK9 to the LDL receptor, thus increasing LDL-receptor density and lowering circulating LDL-cholesterol (LDL-C), apo-B100 and Lp(a). Recently released guidelines on management of hyperlipidemia reinforced the attribute of statins as the mainstay of lipid-lowering medication in dyslipidemic at-risk individuals, as every 1.0 mmol/L reducti...

ea0056mte12 | (1) | ECE2018

Controversies in NETs: Is high dose SSA treatment relevant and who needs hemicolectomy?

Kaltsas Gregory

Long-acting somatostatin analogs (SSAs) have long been used for symptom control in patients with functional neuroendocrine tumors (NETs) whereas two recent prospective studies (PROMID and CLARINET) have demonstrated their efficacy in controlling tumor growth in patients with gastrointestinal NETs of different tissue origin. For both purposes currently available agents (octreotide LAR 10–30 mg i.m and lanreotide autogel 60–120 mg s.c.) have been used. In case of refra...

ea0056mte13 | (1) | ECE2018

Erectile dysfunction

Maggi Mario

Erectile dysfunction (ED) is a multidimensional disorder characterized by the inability to have successful intercourse with negative consequences in personal self-esteem and in couple relationship. Organic, relational and intrapsychic problems always concur in determining the erectile problem, although in different combination according to the patient characteristics, including age. Fifteen years ago, we have developed and validated a structured interview to identify and quant...

ea0056mte14 | (1) | ECE2018

Vitamin D for everybody?

Pilz Stefan

Vitamin D deficiency has a high worldwide prevalence. This is of concern for public health because a poor vitamin D status can lead to musculoskeletal diseases such as rickets and osteomalacia, but vitamin D may also prevent extraskeletal diseases such as respiratory tract infections and reduce premature deaths. Several nutritional guidelines have been revised within the last few years leading to and increase of the recommended dietary reference intakes for vitamin D. Based on...

ea0056mte15 | (1) | ECE2018

Your emergency consult about hyponatraemia

Glynn Nigel

Hyponatraemia is the commonest electrolyte disturbance in hospital patients. It may be observed in up to 30% of cases and it has been clearly associated with an increased morbidity and mortality in a diverse array of clinical scenarios. Despite the frequency of the problem, robust evidence examining its importance and comparing treatment options has traditionally been lacking. However, recent years have seen the publication of high-quality prospective studies evaluating the ep...

ea0056mte16 | (1) | ECE2018

Adrenal Incidentaloma

Newell-Price John

An adrenal incidentaloma is a mass in the adrenal gland that is found on imaging that has been performed for reasons other than imaging the adrenal. With the increased use of axial imaging increasing numbers of lesions are found that require assessment. Adrenal incidentaloma are found in 4.5% of abdominal and thoracic CT scans. The incidence increases with age, being found in <1% of scans in those aged <20 y but in around 10% at 70 y. These adrenal masses are encounter...

ea0056mtbs1 | (1) | ECE2018

Abstract unavailable...

ea0056mtbs2 | (1) | ECE2018

Single-cell technologies in development and disease with a special emphasis on endocrine systems

Rizzoti Karine

Recently developed single cell technologies offer unprecedented investigations of cellular heterogeneity. While significant hurdles remain to be overcome, the field is progressing rapidly. In addition to now commonly performed genome and transcriptome analysis, it appears possible to examine the epigenome, proteome and metabolome at the single cell level. In addition, multi-omics technologies are being developed to profile simultaneously different material sources from the sam...

ea0056mtbs3 | (1) | ECE2018

Watch out for noncanonical mechanisms of thyroid hormone action!

Moeller Lars

Thyroid hormone (TH) and TH receptors (TRs) α and β act by binding to TH response elements (TREs) in regulatory regions of target genes. This nuclear signaling is established as the canonical or type 1 pathway for TH action. Nevertheless, TRs also rapidly activate intracellular second-messenger signaling pathways independently of gene expression (noncanonical or type 3 TR signaling). To test the physiological relevance of noncanonical TR signaling, we generated knock...