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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

Oral Communications

Benign thyroid diseases

ea0056oc1.1 | Benign thyroid diseases | ECE2018

Familial gestational hyperthyroidism caused by Val597ile mutant of TSH receptor gene with human chorionic gonadotropin hypersensitivity

Caron Philippe , Susini Marion , Savagner Frederique

Context: Familial gestational hyperthyroidism caused by mutations of TSH receptor gene, hypersensitive to hCG, is rare. Only two mutations at the same amino acid (lys183Arg, Lys183Asn) in the leucine-rich region of the extracellular N-terminal domain of the TSH receptor have been reported.Patients: A 38-year-old woman was seen during the first trimester of her second pregnancy for weight loss (5 kgs), nausea and vomiting. Thyroid function test revealed t...

ea0056oc1.2 | Benign thyroid diseases | ECE2018

Relationship between TSH values in the first trimester of pregnancy and obstetric and neonatal complications

Moreno Beatriz Torres , Carvajal Gabriela Castillo , Fernandez Lucrecia Vegara , Lopez del Val Teresa , Lazaro Victoria Alcazar , Benfail Lina , Carrera Covadonga Torres , Lacalle Concepcion Garcia , Lago Maria Carmen Orizales , Zuniga Leonardo Ramos

Introduction: In recent years, numerous studies on the relationship between the TSH of the first trimester of pregnancy and obstetric complications have been published, and in this context it has been recommended to treat with levothyroxine from certain values of TSH. The aim of this study was to determine the incidence of obstetric and neonatal complications in pregnancies with normal TSH (0.14 to 2.49 mcU/ml) as a basis for assessing complications in pregnancies with TSH bet...

ea0056oc1.3 | Benign thyroid diseases | ECE2018

Thyroid hormone replacement therapy for subclinical hypothyroidism in adults: systematic review and meta-analysis of randomized-controlled trials

Snel Marieke , Feller Martin , Moutzouri Elisavet , Ford Ian , Gussekloo Jacobijn , Kearney Patricia , Mooijaart Simon , Quinn Terry , Aujesky Drahomir , Stott David , Westendorp Rudi , Rodondi Nicolas , Dekkers Olaf

Introduction: Although widely prescribed, the benefit of thyroid hormone replacement in subclinical hypothyroidism (SHypo) is unclear. We performed a systematic review and meta-analysis of randomized controlled trails (RCTs) to assess the impact of thyroid hormone therapy on clinical outcomes.Methods: We followed the PRISMA guidelines and registered the study protocol on PROSPERO (CRD42017055536). We searched PubMed, Embase, Web of Science, COCHRANE Libr...

ea0056oc1.4 | Benign thyroid diseases | ECE2018

The impact of obligatory iodine prophylaxis on thyroid volume in schoolchildren

Trofimiuk-Muldner Malgorzata , Szybinski Zbigniew , Buziak-Bereza Monika , Sokolowski Grzegorz , Lewinski Andrzej , Zygmunt Arkadiusz , Sworczak Krzysztof , Ruchala Marek , Bandurska-Stankiewicz Elzbieta , Golkowski Filip , Hubalewska-Dydejczyk Alicja

Poland was considered as a mild-to-moderate iodine deficiency area according to results of a nation-wide survey conducted in early 1990-ties. The obligatory iodine prophylaxis program based on iodization of house-hold salt (30 mg of iodide/1 kg of salt) was therefore introduced in 1997.The aim of the study was to assess the real impact of the Polish iodine prophylaxis model on thyroid volume in schoolchildren.Material and methods: ...

ea0056oc1.5 | Benign thyroid diseases | ECE2018

Low free T3 levels within the reference range independently predict cardiovascular mortality in the general population

Neves Joao Sergio , Dias Catarina Viegas , Leitao Lia , Vieira Miguel Bigotte , Magrico Rita , Oliveira Ana Isabel , Falcao-Pires Ines , Lourenco Andre , Carvalho Davide , Leite-Moreira Adelino

Introduction: Several studies have suggested an association of thyrotropin (TSH) and free thyroxine (FT4) levels within the reference range with morbidity and mortality in the general population. Low free triiodothyronine (FT3) has also been associated with a poor prognosis in several conditions. However, the association between FT3 levels within the reference range and the risk of mortality in the general population remains uncertain.Methods: We evaluat...