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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

ea0056p110 | Endocrine tumours and neoplasia | ECE2018

Ectopic adrenocorticotropic hormone syndrome: clinical features, diagnosis, treatment and long-term observation. Impact of bronchial carcinoid tumors

Krylov Vadim , Dobreva Ekaterina , Kharnas Sergey , Parshin Vladimir , Ippolitov Leonid , Kuznetsov Nikolay , Polunin Georgy

Objective: Ectopic adrenocorticotropic hormone (ACTH-ectopic) syndrome (EAS) is a rare cause of ACTH-dependent endogenous hypercortisolism. The objective of this study was to analyze the clinical, biochemical, and radiological features, management, and treatment outcome of patients with EAS.Methods: It was a retrospective case-record study of 47 patients with EAS. Clinical, biochemical, and radiological features and response to therapy and survival rate ...

ea0056p111 | Endocrine tumours and neoplasia | ECE2018

Effect of 177Lu-dotatate on severe, life-threatening, and refractory hypoglycemia associated with malignant insulinoma

Iglesias Pedro , Martinez Alberto , Gajate Pablo , Alonso Teresa , Navarro Teresa , Diez Juan Jose

Malignant insulinoma is an extremely uncommon tumor (5–10% of insulinomas). It is accompanied by severe hypoglycemia and a short life expectancy (survival at 10 years <10%). Its clinical management is complex and constitutes a real therapeutic challenge. So far, the experience of radionuclide treatment in these tumors is scarce. We report the case of a 51-year-old woman diagnosed with pancreatic neuroendocrine tumor (pNET) in January 2013. Pre-surgical imaging study b...

ea0056p112 | Endocrine tumours and neoplasia | ECE2018

Morphological changes of the adrenal glands with hypertension with a crisis current

Chobitko Victoriya , Maksimova Olga , Orlova Marina , Frolova Arina

Assess the morphology of focal lesions of the adrenal glands after adrenalectomy, compare the results with the nature of the course of hypertension, the level of blood pressure, age, sex of patients.Materials and methods: Forty-four medical maps of patients operated on for focal formations of the adrenal glands were analyzed. The clinical symptoms, the hormonal activity of adrenal gland tumors - the level of cortisol, aldosterone, potassium, sodium, reni...

ea0056p113 | Endocrine tumours and neoplasia | ECE2018

Atypical manifestation of adrenocortical carcinoma – case series

Nowak Karolina , Lebek-Szatanska Agnieszka , Samsel Radoslaw , Cichocki Andrzej , Roszkowska-Purska Katarzyna , Zgliczynski Wojciech , Papierska Lucyna

Adrenocortical carcinoma (ACC) is a rare malignancy. Authors present three cases of even less commonly encountered manifestation of ACC. Case 1: A 39-year-old male, with decompensated hypertension, was admitted to Department of Endocrinology due to a large tumor of the left adrenal gland (65 mm) revealed in the CT of the abdomen. Non-contrast attenuation was 35HU. After performing MRI with chemical shift, tumor was classified as non-adenoma as there was no significant loss of ...

ea0056p114 | Endocrine tumours and neoplasia | ECE2018

Are there any clinical predictor for malignancy in malignant pheochromocytoma?

Pia Marengo Agustina , Garcia-Sancho Paula , Guerrero Perez Fernando , Peiro Inmaculada , Santacruz Elisa , Ortiz Flores Andres , Jose Diez Juan , Iglesias Pedro , Villabona Carles

Introduction: Malignant pheochromocytoma (MPheo) is diagnosed by the presence of invasion of adjacent structures or distant metastasis. Predictive factors of malignancy for pheochromocytoma (Pheo) are not well known.Material and methods: We retrospectively analyzed clinical, biochemical, radiological characteristics as predictors for malignancy in patients with Pheo in two Spanish tertiary hospitals during the past 35 years. We also evaluated time of rec...

ea0056p115 | Endocrine tumours and neoplasia | ECE2018

New cancer drug targets identified in adrenocortical carcinoma through gene expression profiling

Liang Raimunde , Weigand Isabel , Altieri Barbara , Kircher Stefan , Steinhauer Sonja , Sbiera Silviu , Kroiss Matthias , Rosenwald Andreas , Fassnacht Martin , Ronchi Cristina

Adrenocortical carcinomas (ACC) are associated with heterogeneous prognosis and limited treatment options for advanced stages. Until now no efficient targeted therapies have been identified. This study aims to identify possible new molecular drug targets for a future personalized therapeutic approach. We isolated good quality RNA from 40 formalin-fixed paraffin-embedded tumor samples (33 from primary surgery, 5 from local recurrences and 2 from distant metastasis) of ACC patie...

ea0056p116 | Endocrine tumours and neoplasia | ECE2018

Outcome of adjuvant mitotane therapy in patients with adrenocortical carcinoma: the experience of San Luigi Gonzaga Hospital

Puglisi Soraya , Calabrese Anna , Basile Vittoria , Perotti Paola , Pia Anna , Berchialla Paola , Volante Marco , Reimondo Giuseppe , Terzolo Massimo

Background and objectives: The role of adjuvant mitotane therapy after radical surgery for adrenocortical carcinoma (ACC) is still debated. The aim of our study is to assess the effects of adjuvant mitotane on recurrence free survival (RFS) and overall survival (OS) in non-metastatic ACC patients and to evaluate prognostic factors in adjuvant setting.Methods: Retrospective data were collected from 152 patients affected by ACC (stage I-III) referred to ou...

ea0056p117 | Endocrine tumours and neoplasia | ECE2018

Adrenocortical carcinoma – characteristics and outcome of patients treated at Helsinki University Hospital during the last 15 years

Kostiainen Iiro , Hakaste Liisa , Kejo Pekka , Parviainen Helka , Laine Tiina , Pennanen Mirkka , Arola Johanna , Haglund Caj , Heiskanen Ilkka , Schalin-Jantti Camilla

Background: Adrenal cortical carcinoma (ACC) is a rare malignancy known to be highly aggressive, with few specific treatment options. The objective was to evaluate clinicopathological features and outcome in patients treated at Helsinki University HospitalMethods and patients: We included all patients diagnosed with adrenocortical carcinoma (Weiss score ≥4) at Helsinki University Hospital during the years 2002 through 2017. Patients were identified...

ea0056p118 | Endocrine tumours and neoplasia | ECE2018

Comparative study between familial and sporadic pheochromocytoma

Garcia-Sancho Paula , Marengo Agustina P. , Guerrero Fernando , Peiro Inmaculada , Santacruz Elisa , Jose Diez Juan , Iglesias Pedro , Villabona Carles

Introduction: Pheochromocytomas (Pheo) may appear sporadically (SPheo) or as an autosomal dominant inherited disease, named as familial PHEOs (FPheo). The latter are present in younger patients, and usually with multiple tumors, but may occur in patients with apparently simple sporadic tumors with no other syndromic features.Material and methods: Clinical data of all consecutive patients underwent surgery for Pheo over 35 years in two tertiary referral c...

ea0056p119 | Endocrine tumours and neoplasia | ECE2018

Clinical features, management and outcomes of adrenocortical carcinoma: a case series analysis

Simo-Servat Andreu , Alonso Sara , Guerrero Fernando , Garcia-Sancho Paurla , Marengo Agustina P. , Iglesias Pedro , Jose Diez Juan , Peiro Inma , Villabona Carles

Background: Adrenocortical carcinoma (ACC) is a rare and aggressive neoplasm with a 5-year survival rate <30%. Survival depends mainly on the stage at diagnosis, being surgery the only curative treatment.Objective: To report the clinical features, management and outcomes of a series of ACC in two Spanish tertiary hospitals.Material and methods: All patients with pathological diagnosis of ACC between 2000 and 2017 were included ...

ea0056p120 | Endocrine tumours and neoplasia | ECE2018

A case of multiple endocrine neoplasia type 1 (MEN1) with non-insulinoma pancreatogenous hypoglycemia syndrome (NIPHS) responding to medical treatment with diazoxide

Gunes Elif , Cander Soner , Oz Gul Ozen , Ersoy Canan , Erturk Erdinc

Introduction: The non-insulinoma pancreatogenous hypoglycemia syndrome (NIPHS) identifies a group of hyperinsulinemic hypoglycemic patients with unique clinical, diagnostic, surgical, and pathologic features. A selective arterial calcium stimulation test (SACST) with hepatic venous sampling can be performed to distinguish between a focal abnormality (insulinoma) and a diffuse process (islet-cell hypertrophy/nesidioblastosis). In patients with insulinoma, the response is positi...

ea0056p121 | Endocrine tumours and neoplasia | ECE2018

A case of benign insulinoma successfully treated with endoscopic ultrasound guided radiofrequency ablation

Gueneau de Mussy Pierre , Lamine Faiza , Godat Sebastien , Marino Laura , Di Giorgi Sara , Gonzalez Rodriguez Elena , Desmartines Nicolas , Pitteloud Nelly

Background: Insulinoma is a rare pancreatic neuroendocrine tumor but a life-threatening condition if untreated. Surgical resection is the standard of care with a high cure rate for benign insulinomas but complications can occur in nearly 30% of cases. New non-surgical mini-invasive ablative therapies can be considered in patients with benign insulinoma who are either unfit for surgery or refuse it, although current data are scarce and long-term outcomes are unknown.<p clas...

ea0056p122 | Endocrine tumours and neoplasia | ECE2018

Careful selection of patients with primary aldosteronism using combination of age, serum potassium and CT adrenal glands can avoid the need for adrenal venous sampling prior to adrenalectomy.

Ann Yun , Chin , Swee Du Soon

Introduction: Adrenal venous sampling (AVS) is considered the reference standard to select patients with unilateral aldosterone producing adenoma for adrenalectomy. Recent studies debated the “mandatory” need for AVS before adrenalectomy. We report our experience from a tertiary hospital in Asia on the treatment outcomes of patients with primary aldosteronism (PA) who underwent adrenalectomy without AVS compared to those who had successful AVS....

ea0056p123 | Endocrine tumours and neoplasia | ECE2018

Hormonal secretion prevalence in a series of subjects with adrenal tumors incidentally discovered in clinical practice

Barbu Carmen Gabriela , Pienary Adrian Teodor , Albu Alice , Martin Sorina , Sirbu Anca , Florea Suzana , Fica Simona

The objective of the study was to evaluate the prevalence of secreting profile among a series of subjects with incidental discovered adrenal tumors. Subjects. 139 subjects (112 women and 27 men) diagnosed with adrenal tumors between 2010 and 2015 in our department.Methods: Medical records were retrospectively analysed for demographic data, routine tests, specific adrenal hormones measurements, associated diseases.Results: Regarding...

ea0056p124 | Endocrine tumours and neoplasia | ECE2018

Genetic background as a predictive factor of pheochromocytoma and paraganglioma presentation

Lages Adriana De Sousa , Paiva Isabel , Cardoso Luis , Oliveira Patricia , Rodrigues Dircea , Moreno Carolina , Martins Diana , Oliveira Diana , Ventura Mara , Cunha Nelson , Marques Bernardo , Catarino Diana , Fadiga Lucia , Carrilho Francisco

Introduction: Pheochromocytoma (Pheo) and paragangliomas (PGL) are rare catecholamine-producing tumors.Near 35% of patients have disease-causing germline mutations.10% are malignant although the malignancy rate differs accordingly to the genetic background.Purpose: This study aims to characterize the sample of patients followed on a tertiary Portuguese Center and associate the presence of genetic mutation with clinical presentation.<p class="abstext"...

ea0056p125 | Endocrine tumours and neoplasia | ECE2018

Heterogeneous genetic background of Hungarian patients with pheochromocytoma/paraganglioma requires gene panel testing

Sarkadi Balazs , Zakarias Sara , Liko Istvan , Grolmusz Vince Kornel , Butz Henriett , Toth Miklos , Szucs Nikolette , Igaz Peter , Patocs Attila

Introduction: Pheochromocytomas and paragangliomas (Pheo/PGL) are rare neuroendocrine tumours arising from the adrenal medulla or the symphathetic paraganglia, respectively. Germline mutations are present in ~40% of the patients. To date, at least 16 genes have been demonstrated to be involved in the genetic background of Pheo/PGL. Prioritization in order of genes tested can be applied, but if the probability of a disease-associated germline mutation exceeds 10% the testing of...

ea0056p126 | Endocrine tumours and neoplasia | ECE2018

Gastroenteropancreatic neuroendocrine tumors are predictive for a positive MEN1 germline mutation test: evidence from Hungarian MEN1 cohort

Kovesdi Annamaria , Balogh Katalin , Toth Miklos , Szucs Nikolette , Sarman Beatrix , Pusztai Peter , Reismann Peter , Somogyi Aniko , Borka Katalin , Erdei Annamaria , Deak Veronika , Valkusz Zsuzsanna , Igaz Peter , Patocs Attila , Grolmusz Vince Kornel

Objective: Multiple endocrine neoplasia type 1 (MEN1) is a rare heritable tumor syndrome caused by germline mutations of MEN1 gene affecting mainly the parathyroid, pituitary and pancreas. Phenotype varies widely, even in first-degree relatives. Recently it has been shown that functionally active gastroenteropancreatic neuroendocrine tumors (GEP-NETs), initially frequently diagnosed as sporadic cases, lead to MEN1 diagnosis. Non-functioning tumors are increasingly rec...

ea0056p127 | Endocrine tumours and neoplasia | ECE2018

Adrenocortical cancer – the effectiveness of mitotane therapy depending on the time of therapy and the therapeutic dose

Stepinski Kamil , Jurecka-Lubieniecka Beata , Michalik Barbara , Szpak-Ulczok Sylwia , Soczomski Przemyslaw , Jarzeb Barbara

Introduction: Mitotane-o’p-DDD belongs to insecticides (DDT pesticide contamination), it is the only drug registered by the FDA in treatment in adrenocortical carcinoma (ACC). Treatment effect is controled by mitotane concentration in the blood.Aim: The aim of the study is to evaluate the effectiveness of mitotane treatment in patients with adrenocortical cancer.Material and methods: We retrospectively reviewed data on ACC pat...

ea0056p128 | Endocrine tumours and neoplasia | ECE2018

Ghrelin is overexpressed in adrenal cancers and stimulates proliferation and migration of ACC cell line.

Komarowska Hanna , Rucinski Marcin , Tyczewska Marianna , Sawicka-Gutaj Nadia , Szyszka Marta , Hernik Aleksandra , Klimont Anna , Milecka Paulina , Migasiuk Laura , Biczysko Mateusz , Idasiak-Piechocka Ilona , Karczewski Marek , Czarnywojtek Agata , Ruchala Marek

Purpose: Adrenal cancers are relatively rare, but they have poor prognosis. IGF2 has been confirmed as a factor of adrenal tumors development. Recent data indicate that ghrelin may be an essential factor in cancerogenesis. The aim of our study was to assess ghrelin expression in adrenal tumors, and to investigate the relationship between ghrelin, IGF2 and the clinicopathological characteristics. We also investigated the influence of ghrelin on adenocarcinoma cell line prolifer...

ea0056p129 | Endocrine tumours and neoplasia | ECE2018

The effect of temozolomide on pancreatic neuroendocrine tumours and role of MGMT and MMR system in temozolomide resistance

Blazevic Anela , Dogan-Oruc Fadime , Dedeci Mehtap , van Koetsveld Peter M. , Feelders Richard A. , de Herder Wouter W. , Hofland Leo J.

Background: Temozolomide (TMZ) has been suggested as a treatment option for patients with pancreatic neuroendocrine tumours (PNETs). The tumour response to TMZ has been linked to expression levels of O6-methylguanine-DNA methyltransferase (MGMT) and components of the mismatch repair (MMR) system. However, there is no in vitro data on TMZ sensitivity and the expression of MGMT and MMR components in PNETs. Moreover, the effect of TMZ exposure on chemosensitivity and exp...

ea0056p130 | Endocrine tumours and neoplasia | ECE2018

Treatment with (177Lu)-dotatate in patients with advanced metastatic somatostatin receptor-positive tumors

Martin-Portugues Antonio Ballesteros , Garcia Maria Isabel del Olmo , Arques Pilar Bello , Huerta Angel Segura , Garcia Juan Antonio Mendez , Torres Juan Francisco Merino

Introduction: The NETTER 1 trial resulted in markedly longer progression-free survival (PFS), with preliminary evidence of an overall survival benefit. We report the results of PFS and safety of (177Lu)-DOTATATE in patients treated in our hospital between 2014 and 2017.Methods: Transversal and descriptive study of 22 patients with advanced, progressive, somatostatin receptor-positive tumors who had received previous treatments. All of them were treated w...

ea0056p131 | Endocrine tumours and neoplasia | ECE2018

Severe impairments in health-related quality of life in patients with small intestine neuroendocrine tumors

Matikainen Niina , Karppinen Noora , Linden Riikka , Sintonen Harri , Tarkkanen Maija , Roine Risto , Heiskanen Ilkka , Schalin-Jantti Camilla

Background: The prevalence of small intestine neuroendocrine tumors (SI-NETs) is increasing. Disease progression is often slow, treatment options and long-term survival rates have improved. Health-related quality of life (HRQoL) is considered an important measure of patients’ perception of the burden of their disease and the impact of treatment modalities. Despite this, data on whether improvements in treatment options and survival rates also translate into improved HRQoL...

ea0056p132 | Endocrine tumours and neoplasia | ECE2018

Role of GLUT-2 expression and MGMT methylation for streptozotocin clinical response in adrenocortical carcinoma

Sbiera Silviu , Maukner Alfred , Kroiss Matthias , Quinkler Marcus , Beuschlein Felix , Rosenwald Andreas , Herterich Sabine , Fassnacht Martin

Introduction: Streptozotocin (SZ) is an active drug for the treatment of advanced adrenocortical carcinoma (ACC) in a minority of patients with an objective response rate of <10%. It has been reported that expression of glucose transporter-2 (GLUT-2) is essential for SZ to enter tumor cells and that high activity of O-6-methylguanine-DNA methyltransferase (MGMT) counteracts the alkylating effect of SZ. Therefore, we aimed to clarify the role of GLUT-2 and MGMT in the respo...

ea0056p133 | Endocrine tumours and neoplasia | ECE2018

Presence and functional role of KiSS/KiSS-R system in pancreatic neuroendocrine tumors (panNETs) and its relationship with clinical features and tumor behavior

Alors-Perez Emilia , Pedraza-Arevalo Sergio , Herrera-Martinez Aura , Diaz-Perez Angel J , Caro Teresa , Serrano-Blanch Raquel , Sanchez-Sanchez Rafael , Galvez-Moreno Maria Angeles , Castano-Fuentes Justo P , Luque Raul M , Martinez-Fuentes Antonio J

Pancreatic neuroendocrine tumors (panNETs) are the second most common neoplasm of the pancreas. panNETs arise from cells of the pancreatic islets and comprise a diverse and heterogeneous group of neoplasms. This hampers their systematic study, and the identification of common molecular signatures that might facilitate a better diagnosis of the disease, and the development of efficient therapeutic approaches. Indeed, there are no clinical, biochemical, anatomopathological, immu...

ea0056p134 | Endocrine tumours and neoplasia | ECE2018

Mesenchymal tissue markers as potential drug targets in adrenocortical tumours

Sbiera Iuliu , Altieri Barbara , Feuchtinger Annette , Kircher Stefan , Hofner Kerstin , Walch Axel Karl , Fassnacht Martin , Ronchi Cristina L , Kroiss Matthias , Sbiera Silviu

Introduction: Adrenocortical carcinoma (ACC) is a rare, aggressive tumour with unsatisfactory treatment options in advanced disease. Activation of epithelial to mesenchymal transition (EMT) has been described as causative of metastatic spread in a variety of human cancers. Accordingly, new drugs were developed specifically targeting EMT with a focus on HGF/c-MET and FGF/FGFR signalling. We here asked whether EMT is a relevant mechanism in ACC.Methods: Ex...

ea0056p135 | Endocrine tumours and neoplasia | ECE2018

Multiple endocrine neoplasia type 1: a retrospective monocenter analysis of 73 cases

Modica Roberta , Lo Calzo Fabio , de Cicco Federica , Bottiglieri Filomena , Sciammarella Concetta , Colao Annamaria , Faggiano Antongiulio

Multiple endocrine neoplasia type 1 (MEN1) is an inherited syndrome, affecting multiple endocrine glands whose natural history remains largely unknown. Aim of this study was to assess the epidemiological and clinical profile of MEN1 in a single center. Seventy-three MEN1 patients, belonging to 30 different families, referred at the NET Center of Naples, from 2000 to 2017, were evaluated. Male/female ratio was 0.73, mean age 43 years (range 10–86). Forty-six cases (64%) we...

ea0056p136 | Endocrine tumours and neoplasia | ECE2018

Cell line derived from glioblastoma synthesizes steroid hormone. Effect of enzyme inhibitors

Garcia Luis Manuel Pinacho , Valdez Ricardo A , Navarrete Araceli , Cabeza Marisa , Segovia Jose , Romano Marta C

Glioblastoma (GB) is the most aggressive primary brain tumor, the survival rate is low because of a high prevalence of recidives. The incidence of GB in the adult population is 50% higher in men than in women, which suggest a role of steroid hormones in it is development. Information on GB as a steroidogenic tissue is poor. The objectives of this study were: 1, to investigate the capacity of a human GB cell line to synthesize sex steroids and corticosteroid metabolites, and 2,...

ea0056p137 | Endocrine tumours and neoplasia | ECE2018

Unraveling the incidence and clinical patterns of neuroendocrine neoplasms in Greece, through the experience of multipotent, specialized clinical centers.

Papalou Olga , Kandaraki Eleni , Papadakis Georgios , Nikou Georgios , Diamanti-Kandarakis Evanthia

Introduction: Neuroendocrine neoplasms (NENs) are a heterogeneous group of tumors arising from neuroendocrine cells in the endocrine and central nervous system, the natural history of which remains inadequately understood. Large epidemiological studies are gradually emerging from different countries worldwide, which contribute to the establishment of a spherical view about these tumors. The purpose of this study is to evaluate the epidemiological, clinical and pathological cha...

ea0056p138 | Endocrine tumours and neoplasia | ECE2018

Evaluation of neurofibromatosis type 1 and gastroenteropancreatic neuroendocrine tumors.

Percovich Juan Carlos , Atencia Jose , Garcia Rogelio , Sambo Marcel , Blanco Montserrat , Rotger Amanda , Lopez Dolores , Olmedilla Yoko , Picallo Maria , Velez Marian , Agreda Javier , Brox Noemi , Monereo Susana

Introduction: Neurofibromatosis type 1 (NF1) is an autosomal dominant condition with an incidence of 1 in 2600 to 3000 individuals. Patients with this disorder are characterized by multiple neurofibromas, caf-au-lait macules, axillary freckling, optic gliomas, iris hamartomas, and skeletal abnormalities. Overall risk of developing neoplasms is approximately 2 to 4-fold higher in patients with NF1, with a risk of malignancy estimated between 5 and 15%. Endocrinopathies are some...

ea0056p139 | Endocrine tumours and neoplasia | ECE2018

Prevalence of undiagnosed Medullary Thyroid Carcinoma and Phaeochromocytoma in MEN2A syndrome revealed by cascade screening

Kumar Rakshit , Joshi Mamta , Velusamy Anand , Mcgowan Barbara , Powrie Jake , Izatt Louise , Carroll Paul

Mutations in the RET gene are responsible for Multiple Endocrine Neoplasia type 2A (MEN2A), characterised by Medullary Thyroid Carcinoma (MTC) and Pheochromocytoma (PCC). It is well recognised that there is a genotype-phenotype correlation regarding likelihood of endocrine tumour development. The American Thyroid Association (ATA) has published predictive grading to guide clinical management of patients with RET mutations.Aim: In this study, we aim to as...

ea0056p140 | Endocrine tumours and neoplasia | ECE2018

Achievement of therapeutic mitotane concentrations in management of advanced adrenocortical cancer: a single centre experience in 47 patients

Bakhit Mohamed , Whitelaw Benjamin C , Gilbert Jackie , Coskeran Patsy , Diaz-Cano Salvador , Taylor David R , Taylor Norman T , Ghatore Lea , Lewis Dylan , Vivian Gillian , Sarker Debashis , Ross Paul , Davis Laura May , Clough Jennifer , Hubbard Johnathan G , Galata Gabriele , Prachalias Andreas , Schulte Klaus-Martin , Aylwin Simon J B

Introduction: Multi-modal therapy for adrenocortical carcinoma (ACC) includes surgery, therapy with the adrenolytic agent mitotane and systemic chemotherapy. Achievement of therapeutic mitotane concentrations (≥14 mg/l) has been related to improved outcomes.Aim: To evaluate the effectiveness of a defined* high dose protocol mitotane therapy in patients with advanced ACC (stages III and IV).Methods: Review of patients presenti...

ea0056p141 | Endocrine tumours and neoplasia | ECE2018

Patients with metastatic bone disease and neuroendocrine neoplasms: the experience of a multi-center study

Alexandraki Krystallenia , Tsoli Marina , Uri Inbal , Page Tristan , Pizanias Michail , Thomas Dimitrios , Low Chen Sheng , Mavroeidi Vasiliki , Adesanya Olu , Kolomodi Denise , Rajaventhan Srirajaskanthan , Grozinsky-Glasberg Simona , Weickert Martin , Kaltsas Gregory

Introduction: Neuroendocrine neoplasms (NENs) have variable biological behavior but the majority exhibits a slow progression. Metastatic bone disease (mBD) in NENs is relatively uncommon and not well described albeit associated with an increased mortality.Methods: Seventy-four [37 males (50%), aged(±S.D.) 60.2±19.3] patients with NENs and bone metastases were recruited from 4 centers.Results: Seventy-three ...

ea0056p142 | Endocrine tumours and neoplasia | ECE2018

Clinical features of ‘dedifferentiation’ in advanced pancreatic neuroendocrine neoplasms: the experience of two centers of excellence

Alexandraki Krystallenia , Grozinsky-Glasberg Simona , Kaltsatou Maria , Kyriakopoulos Georgios , Vergadis Chrysovalantis , Pappas Paris , Mavroeidi Vasiliki , Tsoli Marina , Nikolopoulos Georgios , Angelousi Anna , Kostopoulou Akrivi , Choreftaki Theodosia , Rondogianni Dimitra , Delladetsima Johanna Kassiani , Kaltsas Gregory

Introduction: Neuroendocrine neoplasms (NENs) exhibit significant heterogeneity in growth rates. Clinical and histopathological dedifferentiation has been documented but their clinical characteristics have not been described.Aim of the study: The identification of clinical features of a series of pancreatic NENs (pNENs) that developed dedifferentiation during their course.Methods: Fourteen patients (eight males) with mean age(&#177...

ea0056p143 | Endocrine tumours and neoplasia | ECE2018

Clinical features of a gastric neuroendocrine neoplasms type 1 series

Mavroeidi Vasiliki , Tsoli Marina , Karapanagioti Aggeliki , Thomas Dimitrios , Moschouris Panagiotis , Christakou Charikleia , Chrysochoou Maria , Sougioultzis Stavros , Karoumpalis Ioannis , Kaltsatou Maria , Nikolopoulos Georgios , Kaltsas Gregory , Alexandraki Krystallenia

Background: The aim of the study was to assess the clinical features of gastric neuroendocrine neoplasms type 1 (GNEN1).Methods: We have analyzed the clinical data of the first 73 patients with GNEN1 from our registry.Results: The mean age(±S.D.) of the patients (51 (68.9%) females) and the mean follow-up were 55±12.3 years and 28.8±42.2months, respectively. All patients had sporadic tumors and all wer...