Endocrine Abstracts

Case history: We present a 40 year old female admitted with hyperglycaemia, polyuria, polydipsia and weight loss of 6 kg over a 1 month period. She had no night sweats or change in bowel habit. There was no personal or family history of malignancy or diabetes mellitus. She denied any alcohol, cigarette or illicit drug use. She took no prescription or OTC medication. On examination, she was jaundiced with pale mucous membranes. The rest of systemic examination was normal. Capil...

Introduction: The last World Health Organization (WHO) 2016 classification of Pituitary Tumours recommends the determination of transcription factors. During the last few years, silent variants of the main pituitary tumours (PTs) have been described. The mechanisms of silencing of these tumors are still unknown. POU1F1 (Pit1) encodes a member of the POU family of transcription factors that has a relevant role in the differentiation, proliferation and survival of three...

Introduction: Ectopic Cushing’s syndrome (ECS) is due to ACTH secretion of no pituitary neuroendocrine tumors and represents around 5–10% of all cases of ACTH dependent Cushing’s syndromes.Methods: Six cases of ECS diagnosticated from 2008 to 2017 were studied. Patients’ age ranges from 36 to 69 years (mean 53), four females and two males. Three had pancreatic tumors, two small cell lung carcinomas and one pheocromocytoma. At diagnosi...

Introduction: Multiple endocrine neoplasia type 2B (MEN 2B) is an aggressive disorder characterized by medullary thyroid cancer (MTC) and pheochromocytoma. Peptide receptor radionuclide therapy (PRRT) with 177Lu-DOTATATE is an effective new treatment for inoperable or metastatic neuroendocrine tumors (NETs). Hematologic problems, myelodysplastic syndrome or leukemia can be seen after alkylating agent and peptide receptor radionuclide therapy treatments. We present metastatic m...

Introduction: Diagnosis of NETs (neuroendocrine tumors) is based on clinical manifestations, peptide and amine secretion, specialized radiological and nuclear imaging, secured by detailed histology and immunohistochemistry, which should be obtained whenever possible. Biomarkers are still the mainstay in the diagnosis and follow-up of patients with NETs.Case report: We present the case of a 36-year-old patient with no significant pathological personal his...

Introduction: Urgent conditions, as first symptom of endocrine disease, are rather rare in a hospital emergency department. Emergency medicine doctors work in difficult conditions, often under time pressure, they must also be guided by the likelihood of linking symptoms to the disease. Unfortunately, this makes it difficult to diagnose rare diseases. Therefore, without criticising doctors of other specialties, we would like to present our patient’s long journey from the e...

Background: The occurrence of multiple endocrine tumors in the same patient is not always typical and cannot always be classified into a multiple endocrine neoplasia (MEN) type, McCune-Albright syndrome or the Carney complex. Schwannomas are mesenchymal tumors that originate from Schwann cells of peripheral nerve fibers that can associate in some syndromes. 90% cases are benign, involving usually the head, neck and extremities. They are rare in the retroperitoneal region (1&#1...

Introduction: Tumors derived from the paraganglionic system are rare. 90% of them are located on the adrenal gland, and the remaining 10% are extra-adrenal. Within this last group, 85% are located in the abdomen, 12% in the thorax, and 3% in the head and neck region (HNPG). Its proximity to important structures represents a great difficulty for resection. This makes it necessary to refer these patients to reference centers with multidisciplinary teams and specific surgical tra...

Introduction: Tumors derived from the extra-adrenal paraganglionic system are rare (incidence: 0.8/100,000 people/year). In this group, 85% are located in the abdomen, 12% in the thorax, and 3% in the head and neck region (HNPC).Case report: A 46-year-old man, ex-smoker, with a personal history of arterial hypertension, multifactorial secondary polycythemia (obesity, OSA syndrome, hypertrophic cardiomyopathy). Family history: one brother with paraganglio...

Introduction: Topical diagnosis of insulinoma is an actual problem due to the low detection rate of tumors (about 75%) and conflicting data about its localization in pancreas (more than 50%) when using different imaging techniques. This is partly due to the subjectivity of visualizing diagnosis specialists when describing the location of tumor. We assumed that multimodal imaging Fusion will improve the accuracy of topical diagnosis of insulinoma.Aim: To ...