Endocrine Abstracts

Abstract: Somatostatin analogs (SSAs) constitute first-line treatment for patients with neuroendocrine tumors. Somatostatin receptors (SSTRs) are the most common therapeutic, radiotherapeutic, and imaging targets of SSAs. Some G-protein-coupled receptors, including SSTRs, regulate their responsiveness to continuous drug exposure with different degrees of receptor internalization. Thus, SSTR internalization seems to play an important role in predicting the response to SSAs in p...

Acromegaly is a complex disease with an insidious onset and diagnosis can be delayed. The aim of the study was to investigate the diagnostic delay (DD), for patients with acromegaly due to a pituitary tumour in Sweden. Data were obtained from the Swedish National Patient Register. Patients diagnosed between January 1, 2011 and December 31, 2013 in Sweden were included (n=135, 69 men, 66 women). For these patients, the occurrence of pre-defined relevant comorbidities w...

Acromegaly and comorbidities incur large costs in the Swedish health care system. The aim of the study was to describe direct costs since time of diagnosis, for patients with acromegaly due to a pituitary tumour in Sweden. Data were obtained via linkage of nationwide registers. Patients diagnosed between 1 July 2005 and 31 December 2007 in Sweden and with a follow-up of at least 6 years were included (n=105). Direct costs due to use of health care resources and pharma...