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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

ea0056p164 | Bone ' Osteoporosis | ECE2018

Influence of the levels of vitamin D on T-score in HIP measured by DXA of colombian postmenopausal women

Buendia Richard , Cardenas Santiago , Zambrano Monica , Buendia Andres , Varon Maria De Los Angeles , Mier Heidy Carolina , Morales Alejandra , Alejo Adriana , Sanchez Diego

Introduction: The 25hydroxyvitamin(OH)D deficiency has been linked to the risk of postmenopausal fractures and osteoporosis. In Colombia,the prevalence of 25(OH)vitaminD deficiency is high, reaching more than 53% of the total population. It can be stated that hip fracture is one of its most feared complications, with a high risk of mortality and morbidity,which can affect even osteopenic patients. The objective of this study is to assess modifications in hip T-score (using dua...

ea0056p165 | Bone ' Osteoporosis | ECE2018

Potential extension of frax algoritm and probability of bonefracture

Andreadi Aikaterini , Capuani Barbara , Sabato Donata , Romano Maria , Galli Angelica , Pozzi Flavio , Cerilli Marco , Bellia Alfonso , Morte David Della , Lauro Davide

Osteoporosis is a pandemic chronic non communicable disease, with worldwide expansion. This condition and the resulting bone fracture are a maor cause of disability and mortality for millions of people worlwide. Frax is an algoritm that relies on a questionnaire for the prediction of bonefracture. This algoritm it is called Frax and it’s estimates the probability in % to have a fracture in the following 10 years. The aim of the study was to evaluate whether patients lifes...

ea0056p166 | Bone ' Osteoporosis | ECE2018

A case report: FGF23-related tumor-induced osteomalacia in a patient with pulmonary adenocarcinoma

Arai Hiroshi , Kanai Yugo , Nakamoto Yuji , Nagai Hiroki , Sakamori Yuichi , Yasoda Akihiro , Inagaki Nobuya

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by the abnormal production of fibroblast growth factor 23 (FGF23) in the tumor. Here we report a case of TIO with pulmonary adenocarcinoma. A 61-year old woman was referred to our hospital. She was suffering from severe polyarthralgia and bilateral limb weakness. Her blood chemistry revealed high alkaline phosphatase, low phosphate, low calcium, and low 1,25-(OH)2D3. Bone-scintigrap...

ea0056p167 | Bone ' Osteoporosis | ECE2018

Abstract withdrawn....

ea0056p168 | Bone ' Osteoporosis | ECE2018

Features of distal forearm fracture in persons 50 years old and older

Iurova Olga , Marchenkova Larisa

Objective: To identify the prevalent fracture risk factors in the group of persons 50 years and older. Assess their impact on BMD in patients with a distal forearm fracture (DFF-fracture of the radius) over 50 years at low injury.Materials and methods: A comparative study among patients with DFF in the age group 50 years and older. Study based on medical records of city hospital traum depatment. Analised period 2009–2012. All patients underwent R-de...

ea0056p169 | Bone ' Osteoporosis | ECE2018

Effect of surgery vs observation: 6-Year skeletal outcomes in primary hyperparathyroidism

Ramos Laura , Piedra Maria , Munoz Pedro , Vazquez Luis , Amado Jose Antonio

Background and aims: Primary hyperparathyroidism (PHPT) often presents without classical symptoms such as overt skeletal disease or nephrolithiasis. Treatment strategies have been widely discussed. The objective of our research was to study the effect of parathyroidectomy (PTX) compared to observation (OBS) on skeletal outcomes such as bone mineral density (BMD).Subjects and methods: A retrospective observational study was conducted between 1991 and 2014...

ea0056p170 | Bone ' Osteoporosis | ECE2018

Association between Serum FGF21 levels and bone mineral density in healthy postmenopausal Korean women

Shin Mi-Seon , Cho Eun-Hee , Lee Mi Young , Jeong Ji Yun , Kim Jung Min

Objective: Despite beneficial effect of FGF-21 on metabolic disease, there were concerns about adverse effect on bone metabolism, supported by animal studies. However, a recent human study showed the positive association between FGF-21 and bone mineral density (BMD) in health premenopausal women. This study was undertaken to examine the association between FGF-21 and BMD in healthy postmenopausal Korean women who are susceptible to osteoporosis.<p class="a...

ea0056p171 | Bone ' Osteoporosis | ECE2018

Bone geometry is correlated with arterial stiffness in overweight older adults with vitamin D insufficiency

Rodriguez Alexander , Xu Cecilia , McMillan Lachlan , Srikanth Velandai , Scott David , Ebeling Peter

Background: Vitamin D deficiency/insufficiency and adiposity have deleterious effects on skeletal health and can increase arterial stiffness. Additionally, low bone mass is associated with increased arterial disease, but little is known about the association of bone geometry with arterial disease.Objective: To determine the association between bone geometry and arterial stiffness in overweight (body mass index >25 kg/m2], older adults [50&...

ea0056p172 | Bone ' Osteoporosis | ECE2018

Effects of acromegaly on plasma microRNA levels relevant to bone metabolism.

Grebennikova Tatiana , Belaya Zhanna , Nikitin Alexey , Solodovnikov Alexander , Melnichenko Galina

Molecular basis of the bone disorders in patients with acromegaly are largely unknown.Objective: To investigate microRNAs (miRNA) expression profiles that regulate bone metabolism in plasma samples from patients with acromegaly.Materials and methods: Fasting plasma samples were taken from consecutive subjects with biochemically confirmed active acromegaly and healthy volunteers matched by age, sex and BMI. IGF1 was measured by an e...

ea0056p173 | Bone ' Osteoporosis | ECE2018

Is FGF23 a key factor in primary hyperparathyroidism?

Gatu Alina-Andreea , Velicescu Cristian , Repede Dan Ionut , Bilha Stefana , Florescu Alexandru , Matei Anca , Branisteanu Dumitru

Published data regarding the role of FGF23 in primary hyperparathyroidism and its prognostic applicability are scarce and discordant.Aims: To assess FGF23 profile in patients with primary hyperparathyroidism undergoing surgery.Matherials and methods: Longitudinal study involving 48 patients aged 30–80 years with primary hyperparathyroidism caused by solitary parathyroid adenoma, submitted to parathyroidectomy. We evaluated FGF...

ea0056p174 | Bone ' Osteoporosis | ECE2018

Long-term monitoring of echinococcal cyst as a cause of increased lumbar bone mineral density

Cokolic Miro , Ksela Ursa

An 82-year old female with known osteoporosis was reassessed for bone mineral density (BMD) measurement. Her baseline BMD and lumbar spine T-score (L1-L4) measured in 2004 was 0.699 g/cm2, –3.5 SD, total left hip T-score was 0.618 g/cm2, –2.7 S.D. She was treated with alendronate 70 mg, cholecalciferol 7000 IE per week and calcium supplements for some years. On follow-up in 2013 DXA of lumbar spine and hip, BMD of lumbar spine L1-...

ea0056p175 | Bone ' Osteoporosis | ECE2018

Acromegaly patients with vertebral fractures, have lower trabecular bone score despite no difference in bone mineral density, than non-fractured patients and healthy controls

Kuzma Martin , Vanuga Peter , Sagova Ivana , Pavai Dusan , Jackuliak Peter , Killinger Zdenko , Binkley Neil , Genant Harry , Payer Juraj

Introduction: Patients with acromegaly, despite normal or even high bone mineral density (BMD), have prevalent vertebral fractures (VFs). HR-pQCT studies in acromegaly have proposed that impaired trabecular bone microarchitecture possibly plays a role in fragility fracture development. As such, we hypothesized that trabecular bone score (TBS) would be low in patients with acromegaly.Aim of the study: To compare BMD and TBS in acromegaly patients with and...

ea0056p176 | Bone ' Osteoporosis | ECE2018

Atypical femoral fracture-a possible complication in long term use of bisphosphonates (case report)

Florescu Alexandru , Lisnic Vasile , Galesanu Corina

One of the clinical complications associated with the long term use of bisphosphonates treatment in osteoporosis is the atypical femoral fracture (AFF).Even the absolute risk is low and acceptable compared with the number of fractures prevented, there are still reasonable concerns due to the wide prescription of bisphosphonates and the existence of several case series proving that bisphosphonates have a strong association with this unique fracture type. We present a case of a ...

ea0056p177 | Bone ' Osteoporosis | ECE2018

Malignant hypercalcemia induced by denosumab discontinuation in a patient with primary hyperparathyroidism

Camponovo Chiara , Rodriguez Elena Gonzalez

Context: Denosumab, a fully human monoclonal antibody that inactivates receptor activator of nuclear factor k-B ligand (RANKL), is used for osteoporosis treatment because of its potent anti-resorptive properties. Due to its reversible mode of action, bone resorption increases rapidly after its discontinuation and is accompanied by a quick loss of bone mineral density. Spontaneous vertebral fractures at this period have been recognized as secondary to the rebound of bone resorp...

ea0056p178 | Bone ' Osteoporosis | ECE2018

An extremely high risk of recurrent fractures in an elderly patient, identified with the implementation of Fracture Liaison Service (FLS) in a trauma hospital.

Rizina Diliara , Farba Leonid

Introduction: Osteoporosis is a serious problem all over the world. The presence of low-energy fractures increases the risk of repeated fractures twice. Each new fracture increases the risk of a fatal outcome in the future. Globally, the most effective model of re-fractures preventing in patients with osteoporosis is a Fracture Liaison Service (FLS). FLS main objectives are identification of patients, assessment of re-fractures risks, diagnosis and initiation of osteoporosis t...

ea0056p179 | Bone ' Osteoporosis | ECE2018

The comparison of parathyroid neoplasms mappings evaluated by using gray scale ultrasound images and histopathological whole slide images

Yazgan Aylin Kilic , Topaloglu Oya , Seyrek Fatma Neslihan Cuhaci , Ozdemir Didem , Alkan Afra , Kilic Mehmet , Ersoy Reyhan , Cakir Bekir

Aim: The aim of this study is to correlate the histopathological cell types and morphologic features of parathyroid neoplasms with ultrasound(US) images and laboratory findings, and also gain more information about the clinical importance of these results.Materials and methods: The parathyroid lesions of 57 patients who were operated for hyperparathyroidism were sampled on saggital plane. The slides were scanned on high resolution and digital whole slide...

ea0056p180 | Bone ' Osteoporosis | ECE2018

Evaluation of bone mineral density and vertebral fracture incidence in a group of kidney transplant recipients

Yavuz Dilek Gogas , Kahveci Arzu , Bugdayci Onur , Tuglular Serhan

Kidney transplant patients are prone to metabolic bone diseases. In this descriptive clinical study we aimed to evaluate the incidence of osteopenia osteoporosis, vertebral fractures in our group of renal transplant patients.Methods: Eighty seven patients (25 males and 62 females) aged from 20 to 67 years, who had undergone kidney transplantation 1 to 20 yrs. previously included in the study. Bone mineral densitometry was performed using dual-energy X-ra...

ea0056p181 | Bone ' Osteoporosis | ECE2018

PTH correlates with bone turnover serum markers in patients with end stage renal disease

Dusceac Roxana , Niculescu Dan Alexandru , Dragne Madalina Cristina , Dobre Ramona , David Cristiana , Tacu Cristian , Poiana Catalina

Background: End stage renal disease is usually associated with high serum parathyroid hormone (PTH) and increased bone turnover. The aim of our study was to correlate serum PTH with serum markers of bone turnover in patients with end stage renal disease (ESRD).Methods: We measured serum PTH, osteocalcin, procollagen type 1 n-terminal propeptide (P1NP) and beta-crosslaps in 64 (32 men) consecutive pacients, median (25, 75 percentile) age 61 (49.5, 65.5) y...

ea0056p182 | Bone ' Osteoporosis | ECE2018

Rapid washout in primary, secondary, and tertiary hyperparathyroidism and utility of dual radiopharmaceutical acquisition with 99Tc-sestamibi-123I for localization of parathyroid adenomas

Kushchayeva Yevgeniya , Kushchayev Sergiy , Tella Sri Harsha , Nostrand Douglas Van , Kulkarni Kanchan

99mTc-Sestamibi (SeS) is a standard tool for localization of adenomas/hyperplasia (PA) in hyperparathyroidism (HPTH), designed on the difference between thyroid and parathyroid tissue radiotracer washout on early and late scintigraphy phases. However, PA have been reported to washout as fast as normal thyroid tissue (‘rapid washout’, RW), which may lead to diagnostic failure. The aim of the study was to determine a correlation of RW of SeS from parathyroid...

ea0056p183 | Bone ' Osteoporosis | ECE2018

Trabecular bone score in patients with active acromegaly

Tsoriev Timur , Belaya Zhanna , Sasonova Natalia , Chernova Tatiana , Melnichenko Galina , Dedov Ivan

Introduction: In previous studies, it was noted that increased serum growth hormone (GH) and insulin-like growth factor-1 (IGF-1) lead to the increased vertebral fractures risk in patients with acromegaly. This may be explained by the altered quality of bone rather than bone mineral density (BMD) loss. Trabecular bone score (TBS) is an easily available tool to obtain some surrogate information on bone microarchitecture from a routine DXA.Objective: To ev...

ea0056p184 | Bone ' Osteoporosis | ECE2018

Gut and bone connection: celiac disease presented as hypertrophic osteoarthropathy

Ruanpeng Darin , Harindhanavudhi Tasma

A 52-year-old postmenopausal woman was referred to endocrinology clinic for evaluation of persistent isolated elevation of alkaline phosphatase during routine check-up. Her past medical history was notable for hypothyroidism and vitamin D deficiency. She denied history of fractures or kidney stone. She denied using over the counter supplement, alcohol, smoking or drug use. Family history was suggestive of autoimmune disease, including celiac disease, type 1 diabetes, rheumatoi...

ea0056p185 | Bone ' Osteoporosis | ECE2018

The main bone mass predictors in healthy young and middle-aged men: lean mass and estradiol

Bilha Stefana Catalina , Ungureanu Maria-Christina , Cianga Petru , Buzduga Catalin , Gatu Alina , Aancute Adrian , Zaharia Valentin , Constantinescu Daniela , Covic Adrian , Branisteanu Dumitru

Introduction: Despite the high burden of osteoporotic fractures, bone evaluation in men is not without flaws, being frequently undervalued. We aimed at investigating the role of body composition, adipokines and classic bone determinants (sex hormones) as predictive factors for bone mass parameters in healthy young and middle-aged men.Materials and methods: Anthropometric, bone mineral density (BMD) (assessed by Dual X-Ray Absorptiometry;DXA) and body com...

ea0056p186 | Bone ' Osteoporosis | ECE2018

Teriparatide treatment in a patient with atypical femoral fractures associated with long-term bisphosphonate therapy

Bestepe Nagihan , Aydin Cevdet , Evranos Berna , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

Introduction: Bisphosphonates are the most commonly used drugs for the treatment of osteoporosis and have been shown to improve bone mineral density and reduce fractures. However, approximately a decade ago, atypical femoral shaft fractures were found to be a rare complication of bisphosphonate treatment. Atypical Femoral Fractures (AFF) represent fractures located between the lesser trochanter and the supracondylar flare of a femur. An increasing pool of evidence supports the...

ea0056p187 | Bone ' Osteoporosis | ECE2018

Detection of pulmonary metastases with 18F-Fluorocholine PET/CT and treatment of refractory hypercalcemia with denosumab in a patient with long term parathyroid carcinoma

Bestepe Nagihan , Topaloglu Oya , Soydal Cigdem , Yildirim Nilufer , Ersoy Reyhan , Cakir Bekir

Introduction: Parathyroid carcinoma (PC) mediated hypercalcemia is often severe and more resistant to medical treatment. 18F-Fluorocholine PET/CT is a new technique used for determining the localization of parathyroid lesions. Denosumab, novel antiresorbtive agent, has been shown to have a useful role in hypercalcemia treatment. We report a male patient in long-term follow-up of PC who had refractory hypercalcemia due to pulmonary metastases revealed with 18-Fluorocholine PET/...

ea0056p188 | Bone ' Osteoporosis | ECE2018

Bone mineral density decline following denosumab discontinuation might not be attenuated with previous bisphosphonate therapy

Japelj Miha , Vidmar Gaj , Rajic Antonela Sabati , Pfeifer Marija , Kocjan Tomaz

Objective: Limited data suggest that the rebound increase in bone resorption and rapid bone mineral density (BMD) decline following sudden interruption of denosumab therapy can be avoided in patients previously treated with bisphosphonates. We aimed to compare BMD changes in osteoporotic patients after denosumab discontinuation regarding their previous bisphosphonate (BP) therapy.Material and methods: There were 14 women (age 69 years, BMI 23.1 kg/m...

ea0056p189 | Bone ' Osteoporosis | ECE2018

Novel heterozygous mutation of tissue-non-specific alkaline phosphatase (TNSALP) gene causing late-onset hypophosphatasia

Ruggeri Rosaria Maddalena , Certo Rosaria , Guarnieri Vito , Giovinazzo Salvatore , Ferrau Francesco , Cannavo Salvatore

Background: Hypophosphatasia (HPP) is a rare metabolic, inherited disease of bone metabolism, caused by loss-of-function mutations within the gene coding for TNSALP, that result in a decrease in serum ALP concentrations and consequent accumulation of ALP substrates outside of the cell, including inorganic pyrophosphate which inhibits bone mineralization. HPP leads to a variety of clinical manifestations across all ages and its prognosis is conditioned principally by the skelet...

ea0056p190 | Bone ' Osteoporosis | ECE2018

Orthopedic patient with hearing impairment and dizziness due to the undiagnosed Paget’s disease of bone

Sausa Sintija , Steina Sandra , Pirags Valdis

A 67-year-old female patient with a more than five-year history of symptomatic treatment of bilateral hip joint arthrosis, lumbar spine spondiloarthrosis as well as progressive hearing impairmen and dizziness was referrred by orthopedic surgeon to the endocrinology ward for diagnostic workup of metabolic bone disease. From the family history it was known that her mother had similar complains by the age of 60, which rapidly led to disability to walk, but she was never properly ...

ea0056p191 | Bone ' Osteoporosis | ECE2018

Tumor-induced osteomalacia associated with mesenchymal tumor: a challenging case report

Daneliene Milda , Krasauskiene Aurelija , Barsiene Lina , Lukosevicius Saulius , Zilaitiene Birute

Introduction: Tumor-induced osteomalacia (TIO) or oncogenic hypophosphatemic osteomalacia (OHO) is a rare paraneoplastic syndrome characterized by renal phosphate wasting leading to hypophosphatemia and secondary osteomalacia. TIO was first described in 1947 by Robert McCance and only 500 of cases have been reported in literature since then, approximately 200 of cases during this decade.Case report: In 2014, a 32-year-old female presented with waist pain...

ea0056p192 | Bone ' Osteoporosis | ECE2018

Osteoprotegerin and bone metabolism markers in postmenopausal women with primary hyperparathyroidism

Brutskaya-Stempkovskaya E.V. , Shepelkevich A.P. , Karlovich N.V. , Yurenia A.V. , Kazlova A.S. , Sosedkova A.V. , Hostina Y.A.

Objective: To study relationship between osteoprotegerin (OPG) and bone metabolism markers in postmenopausal women with primary hyperparathyroidism (PHPT) compared postmenopausal women without PHPT.Materials and methods: We studied 30 postmenopausal women with PHPT, average age 62.5±6.12. The control group were 16 postmenopausal women without PHPT, mean age 59.7±6.28 in physiological menopause. ...

ea0056p193 | Bone ' Osteoporosis | ECE2018

Endocrine osteoporosis characteristics (about 177 cases)

Zahra Iftahy Fatima , El Aziz Siham , Chadli Asma

Background: Osteoporosis is a not uncommon complication of endocrine disease. It may even be accompanied by endocrinopathy. The aim of study was to determine mineral bone density profile of patients with endocrinopathy and define the osteoporosis and osteopenia prevalence in these patients.Materials and methods: Descriptive study included 177 patients followed for endocrinopathy (hypercorticism, hyperparathyroidism, prolactinoma and hypogonadism) in Endo...

ea0056p194 | Bone ' Osteoporosis | ECE2018

Osteoprotegerin and distal radius bone mineral density in postmenopausal women with primary hyperparathyroidism

Brutskaya-Stempkovskaya E.V.

Objective: To study relationship osteoprotegerin (OPG) and distal radius bone mineral density (BMD) in postmenopausal women with primary hyperparathyroidism (PHPT) compared postmenopausal women without PHPT.Materials and methods: We studied 30 postmenopausal women with PHPT, average age 62.5±6.12. The control group were 16 postmenopausal women without PHPT, mean age 59.7±6.28 in physiological menopause. We analyzed anthropometr...

ea0056p195 | Bone ' Osteoporosis | ECE2018

Cystic fibrosis-related bone disease in young adults affected with cystic fibrosis awaiting lung transplantation for end-stage respiratory failure

Cairoli Elisa , Eller-Vainicher Cristina , D'Adda Alice , Briganti Federica , Pappalettera Maria , Tarsia Paolo , Arosio Maura , Chiodini Iacopo

Background: Cystic fibrosis-related bone disease (CFBD) is an emerging complication of cystic fibrosis (CF), especially in CF-lung transplant candidates for end-stage disease.Objectives: The assessment of vitamin D levels, bone mineral density (BMD) and morphometric and clinical prevalent fragility fractures in a cohort of young adults affected with CF awaiting lung transplantation for end-stage respiratory failure.Methods: In 42 C...

ea0056p196 | Bone ' Osteoporosis | ECE2018

Recurrent vertebral fracture after denosumab discontinuation in a male patient with severe osteoporosis

Anagnostis Panagiotis , Paschou Stavroula , Potoupnis Michael , Tsiridis Eleftherios , Goulis Dimitrios

Introduction: Discontinuation of denosumab may rarely lead to rebound fractures, although the evidence is low, since available data have derived from case reports and post-hoc analyses.Case presentation: A 45-year old Caucasian male was presented at the outpatient clinic in February 2016 for evaluation and management of severe osteoporosis, which had been complicated with multiple vertebral low energy fractures at the 10 th to 12th ...

ea0056p197 | Bone ' Osteoporosis | ECE2018

Microindentation in the study of bone properties for type 1 diabetes mellitus patients

Ballesta Silvia , Jose Chillaron Juan , Guerri Robert , Diez Alfonso , Herrera Sabina , Ascoeta Nicolas , Guell Anna , Antonia Flores-Le Roux Juana

Background and aims: Patients with T1D present some predisposing factors to fractures. The aim of the present study is to analyse the bone tissue quality in T1DM women and healthy controls by bone microindentation, as well as their relationship with bone mineral density (BMD).Materials and methods: Cross-sectional study including 45 women with T1D at least with one year of duration and 21 healthy controls adjusted by age and BMI. Women with osteoporosis ...

ea0056p198 | Bone ' Osteoporosis | ECE2018

Relationships between hormonal parameters, body fat distribution and bone mineral density in women with menstrual disorders

Syrenicz Malgorzata , Sowinska-Przepiera Elzbieta , Andrysiak-Mamos Elzbieta , Kiedrowicz Bartosz , Sieradzka Anna , Syrenicz Anhelli

Available evidence suggests that unfavorable changes in the distribution of body fat resulting from hormonal imbalance associated with ovarian insufficiency may exert detrimental effects on bone mineral density (BMD). The aim of this study was to verify if densitometrically determined volumes of visceral (VAT), female (FAT) and android (AAT) adipose tissue influence BMD in women with menstrual disorders, and if these relationships are modulated by endocrine factors. The study ...

ea0056p199 | Bone ' Osteoporosis | ECE2018

Long term follow up of patients with hypophosphatemic rickets in a Public Institution in Brazil

Vieira Oberger Marques Julia , Cervi Lagana Caio , Frare Junior Neudir , Oliboni Do Amaral Patricia , Besen Debora , Robl Marcela , Zegbi Cochenski Borba Victoria , Aguiar Moreira Carolina

Introduction: Hypophosphatemic rickets comprehends a group of hereditary diseases characterized by hypophosphatemia and defective bone mineralization. The most common form is X-linked, with a prevalence of 1:20.000.Objectives: Describe the follow up of patients with hypophosphatemic rickets in a public center in Brazil.Methods: Patients with hypophosphatemic rickets were selected from a database of Endocrinology and Metabolism Serv...

ea0056p200 | Bone ' Osteoporosis | ECE2018

Genetic polymorphisms may modulate bone and energy metabolism of mountain cycling ultramarathon athlete’s

Alonso Isanete , Matos Andreia , Ribeiro Ricardo , Gil Angela , Cardoso Carlos , Bicho Manuel

Introduction: The interaction between bone and energy metabolism may be enhanced in high demanding physical activities. We hypothesize that genetic background may modulate the exercise-associated bone and energy responses of athletes participating of a mountain cycling ultramarathon.Methods: Fifty-five non-professional athletes (mean age 44.8±7.1 years) participating in a 9-day mountain cycling ultramarathon (TransPortugal) were evaluated. Before an...

ea0056p201 | Bone ' Osteoporosis | ECE2018

May polymorphisms of DHFR, CBS and MTHFR genes modulate metabolic and bone remodeling parameters associated with reduced bone mineral density?

Freitas Joana , Carvalho Carla , Ribeiro Carolina , Sarmento David , Paula Barbosa Ana , Rui Mascarenhas Mario , Bicho Manuel

Objectives: To study the association of functional polymorphisms at DHFR, CBS and MTHFR genes with bone mineral density (BMD) and metabolic parameters of bone remodeling.Materials and methods: BMD (g/cm2) was measured by DEXA in 391 subjects: 174 with normal BMD (137F 37M; age=48.79±12.99 years; BMI=29.61±5.22 kg/m2), 62 with osteopenia (48F 14M; age=56.06±12.96 years; BMI=27.64±4.94 kg/m2) and 154 with osteoporosis (119F, 35M; age=64...