Endocrine Abstracts

Introduction: Primary hyperparathyrodism is due to benign parathyroid adenomas in more than 90% and parathyroid cancer (PC) in less than 1% of cases. There are no definite clinical criteria differentiating PCs and adenomas. Another subtype, parathyroid neoplasm of uncertain potential is also referred as atypical parathyroid adenoma (APA) and share a few histopathologic features common to cancers.Case: A 47 year old female patient was consulted due to hyp...

Introduction: Gastroesophageal reflux disease (GERD) is now widely prevalent around the world, with clear evidence of increasing prevalence in many developing countries. Treatment for most people with GERD includes lifestyle changes and medication. Proton pump inhibitors (PPIs) are a mainstay therapy for all gastric acid-related diseases. Long-term use of PPIs is associated with hypomagnesaemia, hypokalemia, hypocalcaemia, osteoporosis and bone fractures, renal disease, and ot...

Introduction: Parathyroid adenoma is the most common cause of primary hyperparathyroidism. Effective preoperative imaging and localizing the parathyroid adenoma is a prerequisite for the surgical treatment. 99mTc-MIBI scintigraphy in combination with ultrasound of the neck are the imaging modalities of choice before parathyroidectomy. However, both have limitations in terms of their efficacy in localizing the adenomas; 11C-Methionine or 18F-Fluorocholine PET/CT has ...

Background: Nowadays, primary hyperparathyroidism is usually diagnosed incidentally, in asymptomatic patients, while only around 15% of patients present the classical manifestations. Osteoclastoma, a benign bone lesion, is usually the late manifestation of hyperparathyroidism.Objective: We present the case of a 52 years old female (non-menopausal) recently diagnosed with ulnar osteoclastoma, primary hyperparathyroidism and secondary osteoporosis.<p c...

Background: Lithium salts have been widely known to induce thyroid dysfunction, however, parathyroid dysfunction due to lithium use is uncommonly encountered. Hypercalcemia is a relatively common consequence of lithium therapy presenting with nonspecific symptoms that may be overlooked. Although cerebral infarction may be an independent event from psychiatric disorders, it can also be a rare complication that must be recognized particularly in patients on lithium therapy.<...

Primary hyperparathyroidism is the third most common endocrine disorder, caused, in the majority of cases, by a single parathyroid adenoma and rarely by multigland adenoma or parathyroid carcinoma. Giant parathyroid adenomas, defined as larger than 3 g, represent an uncommon cause of primary hyperparathyroidism, with only a few cases described in the literature. We present the case of a 47 years old female who presented with a significant, unpainful, left cervical mass associa...

Introduction: Although concomitant primary hyperparathyroidism (PHPT) and papillary thyroid carcinoma (PTC) has been repeatedly reported in medical literature with an incidence of 2.3–4.3%, no causal relationship has been elucidated. In most cases, diagnosis of PTC is mostly incidentally, while PHPT is usually the primary pathology. Recent literature supports the possible role of dual-phase 99mTc-MIBI parathyroid imaging in detecting PTC in patients with PHPT.<...

Introduction: Brown tumors are bone lesions that arise due to osteoclastic activity and may mimic a true neoplasm. We encountered an unusual case of hyperparathyroidism with multiple brown tumors that mimicked metastatic bone tumor due to false positive results on computed tomography (CT).Case: 60 year old gentleman presented to the medicine out patient department with complains of fever, cough and right chest pain. Due to severe chest infection he was a...

Introduction: Parathyroid adenoma is the most common cause of primer hyperparathyroidism (PHPT). Mediastinal ectopic parathyroid adenomas constitute about 1–3% of the cases. Brown tumors ocur in less than 2% of the patients with PHPT. Moreover, those skeletal manifestations are even rarely demonstrated with maxillofacial bones involvement.Case presentaton: Here we report a 36-years-old woman presented with approximately 30×26 mm mass growth in ...

Pseudohypoparathyroidism and related hormone resistance disorders have very heterogeneous clinical course and might be recognized only in the adulthood, particularly with the development of hypocalcemia. We present a 41 years old male patient who underwent a neurological investigation because of progressive muscle weakness and elevated creatinine kinase. Very low serum calcium (1.46 mmol/l) with hyperphosphatemia, low magnesium and high normal PTH were measured. The patient al...

Introduction: Hypercalcemia is a frequent hydroelectrolytic disorder, and primary hyperparathyroidism is the most common cause in oupatients. It is important to make an early diagnosis and adequate treatment in order to avoid possible complications such as nephrolithiasis, osteoporosis or the deterioration of glomerular filtration rate.Clinical case: A 63-year-old female patient referred for hypercalcemia. Past medical history included stage IV chronic r...

Introduction: Although co-association between thyroid disease and parathyroid disease is rare, co-existence between parathyroid adenomas (HPPs) and papillary thyroid carcinomas (PTC) is rare. Perhaps this can be explained by the different embryological origins of the thyroids cells with the parathyroid cells.Objectives: To report a case with parathyroid adenoma and multifocal papillary thyroid carcinoma.Case presentation: A 62-year...