Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 56 | ECE2018 | Next issue

20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

Card image cap
ECE 2018, 19 - 22 May 2018; Barcelona, Spain

Poster Presentations: Diabetes, Obesity and Metabolism

Cardiovascular Endocrinology and Lipid Metabolism

ea0056p292 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Effects of atorvastatin and ezetimibe therapy on LDL Cholesterol. A systematic review and meta-analysis of randomized controlled trial

Buendia Richard , Zambrano Monica , Buendia Andres , Vargas Tatiana , Morales Alejandra , Alejo Adriana , Cardenas Santiago , Mier Heidy , Sanchez Diego , Arrautt Johann

Background: Evidence has shown that the use of high doses of statins is associated with lower levels of LDL cholesterol and a decrease in cardiovascular events. Likewise, the use of high doses of statins may increase the risk of myopathy, elevation of liver enzymes, renal failure and cognitive alterations. We conducted a systematic review with a meta-analysis of all RCTs investigating the impact of atorvastatin and ezetimibe therapy on levels of LDL cholesterol vs high doses o...

ea0056p293 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Your patients say they do not tolerate statins? You can still lower their cardiovascular risk with red yeast rice supplementation

Kuzior Agnieszka , Santana-Suarez Ana Delia , Nivelo-Rivadeneira Manuel Esteban , Fernandez-Trujillo-Comenge Paula , Arnas-Leon Claudia , Acosta-Calero Carmen , Quintana-Arroyo Sara , Martinez-Martin Francisco Javier

Objectives: Main: To assess the effect on the 10-year risk of cardiovascular events (RCVE) of daily supplementation with a fixed combination of red yeast rice extract (250 mg), berberin 525 mg and coenzyme Q10 (50 mg) in patients with self-reported statin intolerance. Secondary: effects on anthropometric (BMI, SBP, DBP, HR) and laboratory (lipids, fasting glucose and HbA1C in diabetic patients, eGFR, AST, ALT, GGT, CK); self-reported compliance and tolera...

ea0056p294 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Lobeglitazone, a novel thiazolidinedione, improves hepatic steatosis in diet-induced obese mice

choung Sorim , You Bo Ram , Kim Ji Min , Joung Kyong Hye , Kim Hyun Jin , Ku Bon Jeong

Although non-alcoholic fatty liver disease (NAFLD) patients are rapidly growing, there is not optimal therapy to improve NAFLD. NAFLD is strongly associated with insulin resistance. The peroxisome proliferator-activated receptor (PPAR) activator thiazolidinediones (TZD) is an insulin sensitizer, and have been focused as the drug for NAFLD. However, the TZD remain debate as drug of choice on NAFLD because of its conflicting results on the hepatic steatosis and fibrosis. Lobegli...

ea0056p295 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

B-type natriuretic peptide: a biomarker of cardiovascular risk in type 2 diabetes.

Oueslati Ibtissem , Khessairi Nadia , Talbi Emna , Yazidi Meriem , Chaker Fatma , Abdelmoula Jaouida , Chihaoui Melika , Slimane Hedia

Background: Cardiovascular stratification and prevention in type 2 diabetic patients represent a major public health preoccupation in order to reduce their mortality. Several methods of detecting atherosclerosis have been developed such as biomarkers. The aim of this study was to evaluate the association between B-type natriuretic peptide (BNP) and cardiovascular risk (CVR) in type 2 diabetic patients.Methods: We conducted a cross-sectional study in 71 t...

ea0056p296 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Relationship between the triglyceride glucose index and the presence and fibrosis of nonalcoholic fatty liver disease in Korean adults

Kim Min Kyung , Kim Doo Man , Lee Sang Bae , Kang Shinae , Nam Ji Sun , Park Jong Suk , Ahn Chul Woo

Background: Recently, the triglyceride glucose (TyG) index has been considered a surrogate marker of insulin resistance. Insulin resistance is a well known pathogenic factor in nonalcoholic fatty liver disease (NAFLD). However, few studies have investigated the relationship between the TyG index and liver fibrosis in subjects with NAFLD. Thus, we investigated the relationship between the TyG index and liver fibrosis in Korean adults.Methods: In total, 51...

ea0056p297 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Adropin concentration correlates with selected anthropometric and biochemical parameters – preliminary report

Nowak Justyna , Kulik-Kupka Karolina , Zielen-Zynek Iwona , Kowalska Joanna , Hudzik Bartosz , Bedkowska-Szczepanska Agnieszka , Zyla Anna , Zubelewicz-Szkodzinska Barbara

Adropin, hormone playing an important role in carbohydrates and lipids metabolism, improves mainly the glucose homeostasis. It could also play a protective role in pathogenesis and development of cardiovascular diseases. The purpose of the study was to assess the adropin concentration and some parameters of nutritional status (BMI, WHtR, BAI, VAI) as well as biochemical parameters (fasting glucose and insulin, and lipid profile). 25 patients (84% of group was women, n...

ea0056p298 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Silent myocardial ischemia in type 2 diabetes patients with ischemic heart disease

Naumenka Alena , Adzeriho Igar

Objective: The prevalence of silent myocardial ischemia (SMI) is more frequent in diabetic patients and is associated with a worse prognosis. It has been known that diabetes is a major cardiovascular risk factor; it often leads to severe cardiovascular complications, and coronary artery disease (CAD) is the main cause of death in diabetic patients. The aim was to examine the prevalence and duration of SMI in type 2 diabetes (DT2) patients with ischemic heart disease (IHD)....

ea0056p299 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

PCSK9 inhibitors as an add on for the treatment of dislipemia in real clinical practice

Garcia Carmen Hernandez , Perdigones Cristina Maria Diaz , Fuentes Miguel Damas , Martinez Clara Estaun , Ramos Andrea Sanchez , Ramos Ana Molina , Madueno Francisco Tinahones

Introduction and objectives: The treatment with monoclonal antibodies that inhibit proprotein convertase subtilisin-kexin type 9 (PCSK9) is a new group of drugs that allows us to reach the therapeutic targets of low density cholesterol (LDL-c) in patients intolerant to statins or those who despite treatment with maximum doses of them do not obtain a proper lipid control.Material and methods: We performed a descriptive observational study. We include all ...

ea0056p300 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Treatment adherence through an Integral Care Program for patients with Metabolic Syndrome in Central Mexico

Munoz-Lopez Daniela Beatriz , Ramos-Borja David , Espino-Reyes Marisol , Reyes-Perez Veronica , Preciado-Puga Monica del Carmen , Gonzalez-Yebra Ana Lilia , Quintana-Vargas Silvia

Introduction: The Metabolic Syndrome (MS) is a cluster of risk factors that are related to cardiovascular disease. In Mexico, the prevalence of MS in adults according to the ENSANUT 2012 is 41%, and it has become a public health problem making it necessary to implement strategies for its management at the lowest cost possible that could encourage adherence to treatment.Objective: To evaluate the effectiveness of a comprehensive care program to achieve an...

ea0056p301 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Searching the best feeding habits to improve atherogenic dyslipidemia and inflammatory activity in patients with psoriatic arthritis

Cayon-Blanco Manuel , Garcia-Figueras-Mateos Carolina , Menor-Almagro Raul

Introduction: There is solid epidemiologic evidence linking psoriasis and psoriatic arthritis (PsA) to cardiovascular risk factors and an increased risk for developing cardiovascular diseases. Despite this, dietetic advice is not routinely performed in clinical practice in patients with inflammatory arthropathies and the potential effect of diet on metabolic profile and inflammatory activity is few studied in these patients. This research aims to describe dietetic habits of a ...

ea0056p302 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Worse MELD score is linked to a higher rate of metabolic syndrome in HIV/HCV co-infected patients on highly active antiretroviral therapy

Garcia-Figueras-Mateos Carolina , Cayon-Blanco Manuel

Introduction: The prevalence of metabolic syndrome (MetS) is increasing in patients with HIV infection on highly active antiretroviral therapy (HAART). Additionally, HCV coinfection is common among HIV patients in our area. It is widely known MetS impacts on the liver in different ways but relationship between both MetS and liver function is few studied in HIV/HVC co-infected population.Methods/design: Cross-sectional study including 35 HIV/HVC co-infect...

ea0056p303 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Improved lipid profile and cardiovascular risk factors after bariatric surgery

Gonzalez Elena , Urioste Ana , Barajas David , Fernandez Paula , Ramos Tania , Alejo Mirian , Hernandez Ana , Garcia Sara , Pintor Begona , Gonzalez Luis , Cano Isidoro , Ballesteros Maria

Background: Bariatric Surgery (BS) is an effective treatment for the metabolic control of obese patients. One of its purposes is to improve the lipid profile and reduce cardiovascular risk.Aims: • To determine the changes in lipid profile and other cardiovascular risk factors before and one year after BS.• To assess differences in lipid parameters depending on the surgical procedure used.• To a...

ea0056p304 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Efficacy and safety of proprotein convertase subtilisin/kexintype nine inhibitors in real life experience

Navarro-Hoyas Clara , Moragrega Raquel Miralles , Delegido-Gomez Laura , Lopez-Munoz Beatriz , Moreno-Perez Oscar , Pico-Alfonso Antonio , Gonzalez-Sanchez Victor

Introduction: PCSK9 inhibitors (iPCSK9) have previously been evaluated through controlled clinical trials showing up to 60% reduction in LDL cholesterol concentrations. However, we still do not have enough data regarding the real life experience of the treatment.Objectives: 1) Describe patients with hypercholesterolemia treated with iPCSK9 in clinical practice.2) Evaluate treatment efficacy and safety.Methods...

ea0056p305 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Plasma insulin levels in patients with the different severity of atherosclerotic lesions of coronary arteries

Mankovsky Georgiy , Stepura Olena

Introduction: There is growing body of evidence that insulin resistance and hyperinsulinemia can contribute to development and accelerate the progression of atherogenesis of large arteries. However, an association between the severity of angiographically confirmed atherosclerotic lesions of coronary arteries and the levels of insulin in the plasma in patients with ischemic heart disease (IHD) without history of diabetes mellitus or dysglycemia was not properly examined. The ai...

ea0056p306 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

A multi-disciplinary approach to the management of NAFLD improves both liver and metabolic health and is cost effective

Moolla Ahmad , Motohashi Kenzo , Shard Amelia , Marjot Tom , Ainsworth Mark , Tomlinson Jeremy , Cobbold Jeremy

Introduction: Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and is tightly associated with type 2 diabetes (T2DM), the principal risk factor for disease progression, liver failure and cardiovascular complications. At present there are no licensed therapies and management aims to optimise metabolic risk factors through weight loss, and pharmacological interventions for diabetes and cardiovascular disease. A multidisciplinary approa...

ea0056p307 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

A case of combined dyslipidemia with two different defined genetic alterations

Sel Aydin Tuncer , Akturk Mujde , Deniz Muzaffer Serdar , Bolayir Basak , Ezgu Fatih Suheyl , Altinova Alev , Toruner Fusun , Yetkin Ilhan

Background: There are plenty of primary genetic or secondary causes for both hypercholesterolemia and hypertriglyceridemia. Two different genetic causes in one patient does not generally come to mind in first place.Aim: We report a case who has two genetic alterations as a cause of hypercholesterolemia and hypertriglyceridemia.Case report: 62 year-old male referred because of high serum lipid levels. He had no active complaint. The...

ea0056p308 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Soluble ST2, a promising cardiovascular biomarker, is associated with parameters of glucose and bone metabolism in subjects at cardiovascular risk

Francic Vito , Gaksch Martin , Schwetz Verena , Trummer Christian , Pandis Marlene , Aberer Felix , Grubler Martin , Verheyen Nicolas D , Marz Winfried , Pieber Thomas R , Tomaschitz Andreas , Pilz Stefan , Obermayer-Pietsch Barbara

Introduction: Soluble ST2 (sST2) is the truncated soluble form of the ST2 receptor in the circulation. It is a decoy receptor of IL-33 and thereby inhibits the effects of IL-33/ST2 signaling. Elevated levels of sST2 have been associated with various adverse cardiovascular outcomes. Recently, potential associations of sST2 with obesity and type 2 diabetes mellitus (T2DM) have been described in the general population. In this study, we determined possible cross-sectional associa...

ea0056p309 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Comparison of inflamatory parameters, lipid profile and clinical values in patients with clinical and subclinical hypothyroidism

Altan Musa Faruk , Kaya Ahmet

Aim: In this study, we aimed to perform a comparative evaluation of lipid profile, inflamatory markers, clinical parameters, which are related to cardiovascular diseases, and measurements of carotid intima media thickness (CIMT), which is considered to be an indicator of cardiovascular diseases, in patients with overt and subclinical hypothyroidism, all of which have been studied separately in differen studies.Methods: Patients older than 18 years old, w...

ea0056p310 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

High levels of sclerostin are related to cardiovascular mortality

Novo-Rodriguez Cristina , Garcia-Fontana Beatriz , Avila-Rubio Veronica , Castillo Juan De Dios Luna-Del , Andujar-Vera Francisco , Garcia-Fontana Cristina , Morales-Santana Sonia , Rozas-Moreno Pedro , Garcia-Martin Antonia , Munoz-Torres Manuel

Introduction: Cardiovascular disease (CVD) is a health issue, worldwide, particularly in individuals with diabetes. The identification of CVD biomarkers can improve risk stratification. Sclerostin is a modulator of the Wnt/β-catenin signalling pathway in different tissues, and has recently been linked to vascular biology.Objectives: Our objective was to evaluate the relationship between circulating sclerostin levels and cardiovascular and non-cardio...

ea0056p311 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Lipid profile after pregnancy in women with gestational diabetes mellitus

Imen Sebai , Kamilia Ounaissa , Marwa Ben Cheikh , Islem Stambouli , Haifa Abdessalem , Asma Ben Brahim , Rym Yahiaoui , Chiraz Amrouche

Aim: The aim of our study was to describe the lipid profile of Tunisian women after pregnancy with gestational diabetes mellitus (GDM) and to analyze the influence of maternal age, insulin requirement and postpartum glycemic status on lipoproteins changes after pregnancy.Methods: We conducted a cross-sectional study among pregnant women who were referred to the national institute of nutrition for management of GDM. The lipid profile included total choles...

ea0056p312 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Secondary diabetes associated with principal endocrinopathies (about 161 cases)

Zahra Iftahy Fatima , El Aziz Siham , Chadli Asma

Background: Many endocrine diseases can be complicated by diabetes, due to hyperglycemic hormones and insulinresistance. The aim of the work was to analyze prevalence, therapeutic and progressive aspects of secondary diabetes as well as carbohydrate intolerance (CHI) in patients with an endocrinopathy.Materials and methods: A retrospective study was conducted in the endocrinology and diabetology department including 161 patients followed for diabetes or ...

ea0056p313 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Metabolic syndrome and triglyceride-rich lipoproteins

Paredes Silvia , Fonseca Liliana , Carlos Oliveira Jose , Ramos Helena , Palma Isabel

Introduction: Hypertriglyceridemia, a cardinal feature of metabolic syndrome (MS), is associated with cardiovascular disease and abnormal metabolism of apolipoproteins which may form the basis for this relationship. The aim of this study is to evaluate triglyceride-rich lipoproteins profile in MS patients.Material and methods: A retrospective study was performed, including patients evaluated in a tertiary hospital. Patients with thyroid dysfunction, neop...

ea0056p314 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Specificity of mathematical indexes versus histopathological findings in the diagnosis of nonalcoholic fatty liver disease in mexican population

del Carmen Preciado-Puga Monica , Garcia-Ramirez Juana-Rosalba , del Rocio Ibarra-Reynoso Lorena , Gutierrez-Aguirre Karen-Ivette , Velazquez-Villafana Marion , Lazo-de-la-Vega-Monroy Maria-Luisa , Ruiz-Noa Yeniley , Jordan-Perez Benjamin , Garnelo-Cabanas Serafin

Introduction: Non-alcoholic fatty liver disease (NAFLD) is an emerging disease in Mexico and it could become in a public health problem, this one understands a spectrum of histopathological findings ranging from simple steatosis to steatohepatitis and cirrhosis. The gold standard continues to be the liver biopsy, but several mathematical indexes have been proposed, such as non-invasive techniques, however there are very few studies in our population. This study aims to compare...

ea0056p315 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

What changes does pregnancy bring to the lipid parameters of diabetic patients?

Jemai Chaima , Ben Amor Nadia , Khessairi Nadia , Rim Bourguiba , Temessek Aroua , Tertek Hajer , Ben Mami Faika

Objective: The objective of our study is to describe the lipid parameters of pregnant women with diabetes during the three trimesters of pregnancy.Materials and methods: This is a retrospective study that looked at 44 diabetic pregnant women. Clinical biological data were collected from medical records. The personal history of dyslipidemia, pathologies, and medications that may interfere with lipid parameters have been eliminated.R...

ea0056p316 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Identifying metabolic unhealthy obesity using the product of triglycerides and glucose

Fonseca Liliana , Paredes Silvia , Carlos Olivera Jose , Ramos Helena , Palma Isabel

Introduction: There are significant physiologically and clinically differences in profiles between metabolic healthy and metabolic unhealthy obese individuals. Several markers are on study in order to better characterize the metabolic profile of metabolic unhealthy obese individuals. The aim of this work was to determine whether the triglycerides/glucose (TyG) index may be a valuable marker for identifying metabolically unhealthy obesity.Methodology: Met...