Endocrine Abstracts

Background: Evidence has shown that the use of high doses of statins is associated with lower levels of LDL cholesterol and a decrease in cardiovascular events. Likewise, the use of high doses of statins may increase the risk of myopathy, elevation of liver enzymes, renal failure and cognitive alterations. We conducted a systematic review with a meta-analysis of all RCTs investigating the impact of atorvastatin and ezetimibe therapy on levels of LDL cholesterol vs high doses o...

Objectives: Main: To assess the effect on the 10-year risk of cardiovascular events (RCVE) of daily supplementation with a fixed combination of red yeast rice extract (250 mg), berberin 525 mg and coenzyme Q10 (50 mg) in patients with self-reported statin intolerance. Secondary: effects on anthropometric (BMI, SBP, DBP, HR) and laboratory (lipids, fasting glucose and HbA1C in diabetic patients, eGFR, AST, ALT, GGT, CK); self-reported compliance and tolera...

Although non-alcoholic fatty liver disease (NAFLD) patients are rapidly growing, there is not optimal therapy to improve NAFLD. NAFLD is strongly associated with insulin resistance. The peroxisome proliferator-activated receptor (PPAR) activator thiazolidinediones (TZD) is an insulin sensitizer, and have been focused as the drug for NAFLD. However, the TZD remain debate as drug of choice on NAFLD because of its conflicting results on the hepatic steatosis and fibrosis. Lobegli...

Background: Cardiovascular stratification and prevention in type 2 diabetic patients represent a major public health preoccupation in order to reduce their mortality. Several methods of detecting atherosclerosis have been developed such as biomarkers. The aim of this study was to evaluate the association between B-type natriuretic peptide (BNP) and cardiovascular risk (CVR) in type 2 diabetic patients.Methods: We conducted a cross-sectional study in 71 t...

Background: Recently, the triglyceride glucose (TyG) index has been considered a surrogate marker of insulin resistance. Insulin resistance is a well known pathogenic factor in nonalcoholic fatty liver disease (NAFLD). However, few studies have investigated the relationship between the TyG index and liver fibrosis in subjects with NAFLD. Thus, we investigated the relationship between the TyG index and liver fibrosis in Korean adults.Methods: In total, 51...

Adropin, hormone playing an important role in carbohydrates and lipids metabolism, improves mainly the glucose homeostasis. It could also play a protective role in pathogenesis and development of cardiovascular diseases. The purpose of the study was to assess the adropin concentration and some parameters of nutritional status (BMI, WHtR, BAI, VAI) as well as biochemical parameters (fasting glucose and insulin, and lipid profile). 25 patients (84% of group was women, n...

Objective: The prevalence of silent myocardial ischemia (SMI) is more frequent in diabetic patients and is associated with a worse prognosis. It has been known that diabetes is a major cardiovascular risk factor; it often leads to severe cardiovascular complications, and coronary artery disease (CAD) is the main cause of death in diabetic patients. The aim was to examine the prevalence and duration of SMI in type 2 diabetes (DT2) patients with ischemic heart disease (IHD)....

Introduction and objectives: The treatment with monoclonal antibodies that inhibit proprotein convertase subtilisin-kexin type 9 (PCSK9) is a new group of drugs that allows us to reach the therapeutic targets of low density cholesterol (LDL-c) in patients intolerant to statins or those who despite treatment with maximum doses of them do not obtain a proper lipid control.Material and methods: We performed a descriptive observational study. We include all ...

Introduction: The Metabolic Syndrome (MS) is a cluster of risk factors that are related to cardiovascular disease. In Mexico, the prevalence of MS in adults according to the ENSANUT 2012 is 41%, and it has become a public health problem making it necessary to implement strategies for its management at the lowest cost possible that could encourage adherence to treatment.Objective: To evaluate the effectiveness of a comprehensive care program to achieve an...

Introduction: There is solid epidemiologic evidence linking psoriasis and psoriatic arthritis (PsA) to cardiovascular risk factors and an increased risk for developing cardiovascular diseases. Despite this, dietetic advice is not routinely performed in clinical practice in patients with inflammatory arthropathies and the potential effect of diet on metabolic profile and inflammatory activity is few studied in these patients. This research aims to describe dietetic habits of a ...

Introduction: The prevalence of metabolic syndrome (MetS) is increasing in patients with HIV infection on highly active antiretroviral therapy (HAART). Additionally, HCV coinfection is common among HIV patients in our area. It is widely known MetS impacts on the liver in different ways but relationship between both MetS and liver function is few studied in HIV/HVC co-infected population.Methods/design: Cross-sectional study including 35 HIV/HVC co-infect...

Background: Bariatric Surgery (BS) is an effective treatment for the metabolic control of obese patients. One of its purposes is to improve the lipid profile and reduce cardiovascular risk.Aims: • To determine the changes in lipid profile and other cardiovascular risk factors before and one year after BS.• To assess differences in lipid parameters depending on the surgical procedure used.• To a...

Introduction: PCSK9 inhibitors (iPCSK9) have previously been evaluated through controlled clinical trials showing up to 60% reduction in LDL cholesterol concentrations. However, we still do not have enough data regarding the real life experience of the treatment.Objectives: 1) Describe patients with hypercholesterolemia treated with iPCSK9 in clinical practice.2) Evaluate treatment efficacy and safety.Methods...

Introduction: There is growing body of evidence that insulin resistance and hyperinsulinemia can contribute to development and accelerate the progression of atherogenesis of large arteries. However, an association between the severity of angiographically confirmed atherosclerotic lesions of coronary arteries and the levels of insulin in the plasma in patients with ischemic heart disease (IHD) without history of diabetes mellitus or dysglycemia was not properly examined. The ai...

Introduction: Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and is tightly associated with type 2 diabetes (T2DM), the principal risk factor for disease progression, liver failure and cardiovascular complications. At present there are no licensed therapies and management aims to optimise metabolic risk factors through weight loss, and pharmacological interventions for diabetes and cardiovascular disease. A multidisciplinary approa...

Background: There are plenty of primary genetic or secondary causes for both hypercholesterolemia and hypertriglyceridemia. Two different genetic causes in one patient does not generally come to mind in first place.Aim: We report a case who has two genetic alterations as a cause of hypercholesterolemia and hypertriglyceridemia.Case report: 62 year-old male referred because of high serum lipid levels. He had no active complaint. The...

Introduction: Soluble ST2 (sST2) is the truncated soluble form of the ST2 receptor in the circulation. It is a decoy receptor of IL-33 and thereby inhibits the effects of IL-33/ST2 signaling. Elevated levels of sST2 have been associated with various adverse cardiovascular outcomes. Recently, potential associations of sST2 with obesity and type 2 diabetes mellitus (T2DM) have been described in the general population. In this study, we determined possible cross-sectional associa...

Aim: In this study, we aimed to perform a comparative evaluation of lipid profile, inflamatory markers, clinical parameters, which are related to cardiovascular diseases, and measurements of carotid intima media thickness (CIMT), which is considered to be an indicator of cardiovascular diseases, in patients with overt and subclinical hypothyroidism, all of which have been studied separately in differen studies.Methods: Patients older than 18 years old, w...

Introduction: Cardiovascular disease (CVD) is a health issue, worldwide, particularly in individuals with diabetes. The identification of CVD biomarkers can improve risk stratification. Sclerostin is a modulator of the Wnt/β-catenin signalling pathway in different tissues, and has recently been linked to vascular biology.Objectives: Our objective was to evaluate the relationship between circulating sclerostin levels and cardiovascular and non-cardio...

Aim: The aim of our study was to describe the lipid profile of Tunisian women after pregnancy with gestational diabetes mellitus (GDM) and to analyze the influence of maternal age, insulin requirement and postpartum glycemic status on lipoproteins changes after pregnancy.Methods: We conducted a cross-sectional study among pregnant women who were referred to the national institute of nutrition for management of GDM. The lipid profile included total choles...

Background: Many endocrine diseases can be complicated by diabetes, due to hyperglycemic hormones and insulinresistance. The aim of the work was to analyze prevalence, therapeutic and progressive aspects of secondary diabetes as well as carbohydrate intolerance (CHI) in patients with an endocrinopathy.Materials and methods: A retrospective study was conducted in the endocrinology and diabetology department including 161 patients followed for diabetes or ...

Introduction: Hypertriglyceridemia, a cardinal feature of metabolic syndrome (MS), is associated with cardiovascular disease and abnormal metabolism of apolipoproteins which may form the basis for this relationship. The aim of this study is to evaluate triglyceride-rich lipoproteins profile in MS patients.Material and methods: A retrospective study was performed, including patients evaluated in a tertiary hospital. Patients with thyroid dysfunction, neop...

Introduction: Non-alcoholic fatty liver disease (NAFLD) is an emerging disease in Mexico and it could become in a public health problem, this one understands a spectrum of histopathological findings ranging from simple steatosis to steatohepatitis and cirrhosis. The gold standard continues to be the liver biopsy, but several mathematical indexes have been proposed, such as non-invasive techniques, however there are very few studies in our population. This study aims to compare...

Objective: The objective of our study is to describe the lipid parameters of pregnant women with diabetes during the three trimesters of pregnancy.Materials and methods: This is a retrospective study that looked at 44 diabetic pregnant women. Clinical biological data were collected from medical records. The personal history of dyslipidemia, pathologies, and medications that may interfere with lipid parameters have been eliminated.R...

Introduction: There are significant physiologically and clinically differences in profiles between metabolic healthy and metabolic unhealthy obese individuals. Several markers are on study in order to better characterize the metabolic profile of metabolic unhealthy obese individuals. The aim of this work was to determine whether the triglycerides/glucose (TyG) index may be a valuable marker for identifying metabolically unhealthy obesity.Methodology: Met...