Searchable abstracts of presentations at key conferences in endocrinology
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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

ea0056p643 | Endocrine Disruptors | ECE2018

Role of Pro-inflammatory biomarkers in Graves’ disease: A case-control Study

B Rajesh , B Ramesh , M Venkateshwara Reddy , D Vighnesh , G Gayathri , B Rajkiran Reddy , B Chakrapani , PRK Bhargav

Introduction: GravesÂ’ disease (GD) is one of the commonest organ specific autoimmune thyroid disease. Surgical thyroidectomy is one of the definitive treatment modalities. Autoimmunity has been implicated as one of the main cause of GD. In this context, we set out study the role of Pro- inflammatory cytokines in GD.Material and methods: This prospective case-control study was conducted on surgically managed GD patients. Institutional ethical committ...

ea0056p644 | Endocrine Disruptors | ECE2018

Endoplasmic reticulum stress-mediated apoptosis and cell cycle arrest were caused by resveratrol, a phytoestrogen, in malignant melanoma cells

Lee Gun-Hwi , Heo Jae-Rim , Hwang Kyung-A , Choi Kyung-Chul

Resveratrol, a dietary product present in grapes, vegetables, and berries, is phytoestrogen that regulates signaling pathways that control cell division, and growth, apoptosis, and metastasis. Melanoma, also known as malignant melanoma, is a type of cancer that develops from the pigment-containing cells known as melanocytes. Especially, malignant melanoma is pernicious and proliferates more readily than any other skin cancer. In the present study, we evaluated the anti-cancer ...

ea0056p645 | Endocrine Disruptors | ECE2018

Endocrine related adverse events associated with immune checkpoint blockade therapy: a retrospective analysis

Preiato Valentina Lo , Salvagni Stefania , Gianni Caterina , Ribichini Danilo , Bianchi Nicola , Pagotto Uberto , Ardizzoni Andrea , Pelusi Carla

Background: Immune checkpoint inhibitors (ICI) have become a clinically validated treatment for numerous types of tumor including melanoma, lung, and kidney carcinoma. These treatments can cause immune-related adverse events affecting several organs including the endocrine system.Aims: The aim of this study was to characterize the type and the onset of the ICI associated-endocrinopathies.Materials and methods: This retrospective co...