Searchable abstracts of presentations at key conferences in endocrinology
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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

ea0056p680 | Steroid metabolism + action | ECE2018

Characterization of sex hormone binding globulin ligands with potential to enhance sex steroid action

Round Phillip , Das Samir , Wahala Kristiina , Van Petegem Filip , Hammond Geoffrey

Sex Hormone binding globulin (SHBG) is a plasma steroid binding protein that is the major determinant androgen and estrogen access to target tissues. Several ligands of SHBG have been predicted by computational methods or discovered through basic research, they include pharmaceutical, natural plant extracts and anthropogenic endocrine disrupting compounds. In this study we characterized 3,4-Divanillyltetrahydrofuran (DVT), a non-steroidal ligand of SHBG, and Danazol, a synthet...

ea0056p681 | Steroid metabolism + action | ECE2018

Relationship between salivary cortisol circadian rhythm and body composition in the postmenopausal women of the population cohort OsteoLaus

Gonzalez Rodriguez Elena , Papadakis Georgios , Vollenweider Peter , Preisig Martin , Waeber Gerard , Hans Didier , Marques-Vidal Pedro , Lamy Olivier

Introduction: Aging is associated with a decrease in muscle and bone mass, and a gain in fat mass. Similar changes are more pronounced in hypercortisolism. We previously demonstrated that high 8 PM salivary cortisol is independently associated with increased prevalence of radiologic vertebral fractures. We wanted to determine whether salivary cortisol circadian rhythm played also a role on body composition.Material and Methods: Cross-sectional study incl...

ea0056p682 | Steroid metabolism + action | ECE2018

Proteolytically cleaved forms of corticosteroid-binding globulin with low steroid-binding affinity are not present in human plasma

Hill Lesley , Vassiliadi Dimitra , Hammond Geoffrey

Corticosteroid-binding globulin (CBG) transports glucocorticoids in blood and is a serine protease inhibitor family member. Plasma CBG has a reactive center loop (RCL) structure that when cleaved by specific proteases, including neutrophil elastase, results in a loss of high affinity steroid-binding activity. Measurements of CBG levels are typically based on functional assays of its steroid-binding capacity or immunoassays, including enzyme-linked immunosorbant assays (ELISAs)...