Searchable abstracts of presentations at key conferences in endocrinology
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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

ea0056p739 | Growth hormone IGF axis - basic | ECE2018

Craniofacial fibrous dysplasia and long-term untreated GH excess in McCune–Albright syndrome

Lecumberri Beatriz , Gomes Mariana , Kreilinger Jose Juan Pozo , Esteban Isabel , Royo Arantxa , Perez de Nanclares Guiomar , Gomez de la Riva Alvaro

Introduction: Craniofacial fibrous dysplasia, characteristic of McCune-Albright syndrome (MAS), is usually present in patients with MAS related GH excess, and complicates their neurosurgical approach. We describe a 21-year-old male with severe craniofacial fibrous dysplasia and acute obstructive hydrocephalus due to a 39×35 mm cystic lesion in the third ventricle that occluded Monro’s foramina, in whom MAS and long-term untreated acromegaly were discovered.<p cla...

ea0056p740 | Growth hormone IGF axis - basic | ECE2018

GH replacement therapy (GHRT) in adult patients with GH deficiency (GHD): a long term follow up

Peris Begona Pla , Ramos-Levi Ana Maria , Marijuan Clara , Fernandez Elena , Aguirre Nerea , Mosse Alexia , Jimenez Sara , Hernando Inigo , Vargas Marcos Lahera , Azpiroz Monica Marazuela

Introduction: GH deficiency (GHD) leads to altered body composition, lipid metabolism and quality of life, and is also associated to an increased cardiovascular morbidity and mortality. The aim of this study was to evaluate long-term changes after treatment with GH replacement therapy (GHRT).Methods: We retrospectively reviewed adult patients with GHD in our clinic who were treated with GHRT. We evaluated demographic (etiology, age, dose), anthropometric...

ea0056p741 | Growth hormone IGF axis - basic | ECE2018

IGF1 level and GH dose adjustmentin adults with GH deficiency (AGHD): experience from a Registry in France

Borson-Chazot Francoise , Pascal-Vigneron Veronique , Salenave Sylvie , Hacques Evguenia , Villette Beatrice

Objective: IGF1 is the most useful serum marker for GH dose titration in adults. The authors focused on the GH dose adjustment with extreme IGF1 values (<−2S.D.; >+2S.D.).Methods: French observational study of AGHD patients treated with Norditropin®.Prospective follow up until 5 years.Results (median [Q1; Q3]):: 328 AGHD, 39.2±14.3 years old wer...

ea0056p742 | Growth hormone IGF axis - basic | ECE2018

Hirsutism as presenting clinical sign of acromegaly

Pissia Maria , Sapounas Spyridon , Simeakis George , Patinioti Ioanna , Saltiki Katerina , Vasileiou Vassiliki , Alevizaki Maria , Anastasiou Eleni , Zapanti Evangelia

Case report: Hirsutism although common in acromegaly (24%) is not considered as the prevalent symptom of the disease. Here we describe a seventy-one year old woman with a 2-year history of hyperandronism and subtle acromegalic features (macroglossia, sleep apnea). Clinical examination showed hirsutism (Ferrimann-Gallwey score 20/34), acanthosis nigricans and mild clitoridomegaly. Blood examination revealed elevated IGF-1: 502 ng/ml (69–200 ng/ml) and standard oral glucose...