Searchable abstracts of presentations at key conferences in endocrinology
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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

ea0056p903 | Endocrine Disruptors | ECE2018

Correlational evaluation of inflammatory biomarkers in polycystic ovarian disease: a case control study

Gayathri G , Rajesh B , Ramesh B , Vignesh D , Venkateshwara Reddy M , Rajkiran Reddy B , Chakrapani B , Bhargav PRK

Introduction: Contrary to the high prevalence of polycystic ovarian syndrome (PCOS) amongst reproductive age group women, there is disproportionate uncertainity over its etiopathogenesis. Substantial evidence suggests immunological-inflammatory role in causing this endocrine disorder. In this context, we set out study the role of inflammatory biomarkers in PCOS.Material and methods: This prospective case-control study was conducted on PCOS patients diagn...

ea0056p904 | Endocrine Disruptors | ECE2018

Tumor growth of breast cancer was enhanced by fludioxonil, an antifungal agent, via estrogen receptor-dependent pathways

Kim Cho-Won , Go Ryeo-Eun , Choi Kyung-Chul

Previous studies suggest that environmental factors such as high levels of meat consumption, caffeine, cigarette smoking, pesticides, and endocrine disrupting chemicals (EDCs) may enhance the risk of breast cancer. The fludioxonil is an antifungal agent used in agricultural applications and present at measurable amounts in fruits and vegetables. In this study, the effects of fludioxonil on cancer cell viability and migration ability were examined in MCF-7 and T47D breast cance...

ea0056p905 | Endocrine Disruptors | ECE2018

Treatment with pesticides, fenhexamid and cyprodinil, resulted in an increase of cell cycle- and metastasis-related genes in an estrogen receptor-dependent pathway in cellular and xenografted mouse models with MCF-7 breast cancer cell

Go Ryeo-Eun , Choi Kyung-Chul

Fenhexamid (Fen) and cyprodinil (Cyp) are antifungal agents used in agricultural applications. In this study, to examine the effects of two-pesticides on cancer cell viability and metastasis via estrogen receptor pathway, the ER positive-MCF-7 and ER negative-MDA-MB-231 breast cancer cells were used. MCF-7 and MDA-MB-231 were cultured with 0.1% DMSO (control), 17β-estradiol (E2; 1×10−9 M), Fen (10−5–10−7</s...

ea0056p906 | Endocrine Disruptors | ECE2018

Relationship of urinary bisphenol A to metabolic and hormonal profile in PCOS women

Lazurova Zora , Figurova Jana , Hubkova Beata , Lazurova Ivica

Objectives: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in women. Its increasing prevalence is probably related to environmental estrogens exposure, such as bisphenol A (BPA). BPA is considered to play an important role in the ethiopathogenesis of PCOS and can be responsible for various clinical symptoms. Aim of the study was to compare the levels of urinary BPA between PCOS women and healthy controls and to assess the relationship of BPA to sex...

ea0056p907 | Endocrine Disruptors | ECE2018

Cross hormone therapy in transgender individuals: changes in lipid profile and other cardiovascular risk factor

Laguna Ma del Carmen Serrano , Ponce Maria Hayon , Martinez David Blanquez , Perez Maria Dolores Aviles , Vela Elena Torres

Background: Cross-sex hormone therapy (CHT) is known to lead to alterations in cardiovascular risk factor(CVRF).Objective: To assess changes in lipid profile and other CVRF in transsexual subjects receiving CHT.Materials and methods: Retrospective longitudinal study. We evaluated individuals with gender identity disorder following CHT, assisted in the Gender Identity Unit from 2015 to 2017. Primary endpoint was lipid profile change...