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Endocrine Abstracts (2018) 56 GP127 | DOI: 10.1530/endoabs.56.GP127

ECE2018 Guided Posters Female Reproduction (11 abstracts)

Cardiovascular disease in a nationwide population of Danish women with polycystic ovary syndrome

Dorte Glintborg 1, , Katrine Hass Rubin 3 , Mads Nybo 4 , Bo Abrahamsen 3, & Marianne Skovsager Andersen 1

Background: Polycystic ovary syndrome (PCOS) is associated with obesity and low grade inflammation, factors linked to cardiovascular disease (CVD).

Methods: National Register-based study including women with PCOS and no previous diagnosis of CVD or hypertension. PCOS OUH (n=1165) included premenopausal women with PCOS and clinical and biochemical examination. PCOS Denmark (n=18 112) included women with PCOS in the Danish National Patient Register. Three age-matched controls were included per patient (n=52 769). The main study outcome was CVD events including hypertension defined according to nationwide in- and outpatient hospital contact diagnosis codes and/or inferred from filled medicine prescriptions.

Results: The age at inclusion was median (quartiles) 29 (23–35) years and follow up was 11.1 (6.9–16.0) years. The Hazard ratio (95% CI) for development of CVD including hypertension in PCOS Denmark was 1.7 (1.6; 1.8) (P<0.001) and the total event rate of CVD was 19.2 per 1000 patient years in PCOS Denmark vs 11.6 per 1000 patient years in controls (P<0.001). The median age at diagnosis of CVD was 35 (29–42) years in PCOS Denmark vs 36 (30–44) years in controls (P=0.02). Obesity, diabetes, and infertility, and previous use of oral contraceptives were associated with increased risk of development of CVD in PCOS Denmark (P<0.001). Also, age, BMI, blood pressure, lipid status, and glycemic status predicted development of CVD in PCOS OUH.

Conclusion: The event rate of CVD and hypertension was higher in PCOS compared to controls. The risk of developing CVD must be considered even in young women with PCOS.

Volume 56

20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

European Society of Endocrinology 

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