Endocrine Abstracts

Introduction: Papillary thyroid carcinoma (PTC) is the commonest endocrine malignancy. Apart from genetic role in its pathogenesis, autoimmunity has been implicated in certain papers. But, reports have been tripolar ranging from causative, protective and neutral role of immunomodulation. In this context, we set out study the role of Pro- inflammatory cytokines in PTC in South Indian population.

Material and methods: This prospective case-control study was conducted on surgically managed PTC patients. Institutional ethical committee approval was obtained. Diagnosis of PTC was based on imaging, fine needle aspiration cytology and later confirmed by histopathology. Exclusion criteria were subjects with any systemic or chronic inflammatory disease or any medication which interferes with the normal function of the hypothalamic-pituitary-gonadal axis. Serum samples were collected from 53 PTC subjects and 51 age matched healthy controls. Interleukin-6 (IL-6), Tumour necrosis factor-alpha (TNF-α) and high sensitive C reactive protein (hsCRP), leptin levels were measured in all serum samples. Statistical analysis was performed by one way ANOVA with Dunnet’s test and Pearson correlation tests.

Results: The mean hSCRP level in PTC and controls were 17.9±3.1 mg/ml and 5.8±1.3 mg/ml respectively. The mean TNF-α level, IL-6 level and Leptin levels were 294±33 pg/ml, 13.9±4.7 pg/ml and 1.9±0.8 ng/ml respectively. Serum leptin level in controls was 3.4±1.6 ng/ml. There was statistically significant difference of all the pro-inflammatory cytokines compared to controls (P value < 0.05) with negative correlation for leptin levels.

Conclusions: This study shows raised titers of pro-inflammatory markers – IL-6, TNF-α and hsCRP, while reduced leptin levels correlated with PTC suggesting a contributory role. But, the exact immuno-modulatory role and pathogenetic mechanism needs more investigational research.

Keywords: Papillary thyroid cancer, Tumour necrosis factor, Interleukin-6, Goiter, Auto-immunity, Leptin