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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

ea0056p1118 | Thyroid cancer | ECE2018

Mixed medullary–papillary carcinoma of the thyroid: a case report

Belaid Rym , Jaidane Amel , Oueslati Insaf , Zouaoui Chadia , Ouertani Haroun

Introduction: The coexistence of two types of tumors of different origins in the same thyroid is a rare phenomenon. Its etiopathogenesis remains unknown. We report the case of a mixed papillary and medullary carcinoma of the thyroid revealed by a compressive goiter.Case report: A 70-year old woman with a history of right lobo-isthmusectomy for a toxic solitary adenoma, presented 30 years later with a chief complaint of a cervical mass accompanied by diff...

ea0056p1119 | Thyroid cancer | ECE2018

Epidemiology of thyroid nodules in the United Arab Emirates: five-years tertiary center analysis

Alseddeeqi Eiman , Baharoon Raqwana , Al-Helali Abeer , Mohamed Rawia , Ghaith Jinan , Ahmed Luai

Background: Thyroid malignancy is the sixth common cancer type in the United Arab Emirates (UAE) where its incidence is increasing worldwide. There are no epidemiological data outlining the prevalence of cancer in thyroid nodules, nor previous analysis of ultrasonographic features correlating with thyroid malignancy in the UAE.Aim: To report the prevalence of thyroid malignancy in thyroid nodules and correlate it with demographic data. A secondary aim is...

ea0056p1120 | Thyroid cancer | ECE2018

Thyroid ultrasonographic characteristics and Bethesda results after FNAB

Kanouta Fotini , Triantafillou Eleni , Papadakis Georgios , Kalaitzidou Styliani , Drosou Aspasia , Sapera Aggeliki , Tampouratzi Dimitra , Kotis Michalis , Kyrimis Taxiarchis , Drakopoulou Anna , Kaltzidou Victoria , Veniou Eirini , Karavasili Chrysa , Plyta Styliani , Tertipi Athanasia

Objectives: Fine needle aspiration biopsy (FNAB) is the initial investigation of choice for thyroid nodules. The Bethesda System (B) classifies thyroid cytological patterns into six categories (B1-6) according to risk for malignancy.Methods: A total of 1113 patients (210 males/903 females) underwent FNAB for the same number of thyroid nodules. Their mean age was 56.2±21.6 years±S.D. We correlated the demographic profile (age and ...

ea0056p1121 | Thyroid cancer | ECE2018

The diagnostic value of elastography score and strain indexfor the evaluation of thyroid micronodules

Cakal Erman , Karakose Melia , Unsal Ilknur , Sahin Mustafa , Ucan Bekir , Ozbek Mustafa

Background and aim: In the general population, the frequency of thyroid micronodules is increasing and the prevalence of malignancy is higher in nodules at this size. The ultrasonographic features of these nodules are neither spesific nor sensitive Elastography gives information about the degree of hardness at the tissue level and provides assessment of malignancy risk of the nodule. The aim of the study was to investigate the diagnostic value of elastography in patients with ...

ea0056p1122 | Thyroid cancer | ECE2018

Radiofrequency ablation for micropapillary thyroid carcinoma: evaluation of clinical efficacy

Makhonin Aleksandr , Vozdvizhenskii Mikhail , Orlov Andrey , Stadler Vladimir , Matyash Yana

Purpose: Papillary thyroid cancer is the most common type of thyroid carcinoma and represents approximately 80% of all thyroid cancers. The aim of the study is an evaluation of the treatment results of micropapillary thyroid carcinoma by the radiofrequency ablation (RFA).Materials and methods: Fourteen patients with papillary thyroid carcinoma T1aN0M0 with wild type of BRAF (V600E) were included in this research: 12 women and 2 men. The median age of the...

ea0056p1123 | Thyroid cancer | ECE2018

Prevalence and clinical significance of BRAFV600E mutation in patients with papillary thyroid cancer

Williams Alejandra , Santon Almudena , Pian Hector , Cristobal Eva , Iglesias Pedro , Diez Juan J

Background: The BRAFV600E mutation is the most common mutation in papillary thyroid carcinoma (PTC). Its presence has been associated with extrathyroid invasion, lymph node metastasis, and tumor recurrence. Recently, assessment of the BRAFV600E mutation status in patients with PTC has been used as a method to predict tumor aggressiveness.Objective: Our aim has been to analyze the prevalence of BRAFV60...

ea0056p1124 | Thyroid cancer | ECE2018

Association of pro-inflammatory biomarkers in papillary thyroid cancer: a prospective study

Vignesh D , Ramesh B , Rajesh B , Venkateshwar Reddy M , Gayathri G , Rajkiran Reddy B , Chakrapani B , Bhargav PRK

Introduction: Papillary thyroid carcinoma (PTC) is the commonest endocrine malignancy. Apart from genetic role in its pathogenesis, autoimmunity has been implicated in certain papers. But, reports have been tripolar ranging from causative, protective and neutral role of immunomodulation. In this context, we set out study the role of Pro- inflammatory cytokines in PTC in South Indian population.Material and methods: This prospective case-control study was...

ea0056p1125 | Thyroid cancer | ECE2018

An unusual association of three endocrine diseases: pheochromocytoma, hyperparathyroidism and papillary thyroid carcinoma

Iconaru Laura , Baleanu Felicia , Karmali Rafik

Introduction: Pheochromocytoma, papillary thyroid carcinoma and primary hyperparathyroidism have been reported rarely together. Whether the association is coincidental or results from an underlying unique genetic process is difficult to ascertain.Case description: We report a case of a 59-year-old woman without a family history who had a personal history of multinodular goiter known for the ten last years and pheochromocytoma diagnosed and operated in 20...

ea0056p1126 | Thyroid cancer | ECE2018

Coexistence of well differentiated, poorlydifferentiated and anaplastic thyroid carcinoma in a male patient with neurofibromas: A case report

Boutzios Georgios , Papaoiconomou Eleni , Pikoulis Andreas , Pouloudi Despoina , Pikouli Anastasia , Koukoulioti Eleni , Lazaris Andreas , Pikoulis Emmanouil

Introduction: Poorly differentiated thyroid carcinoma (PDTC) and anaplastic thyroid carcinoma (ATC) have been conjectured to arise from well differentiated thyroid carcinoma (WDTC) due to frequently reported synchronous and metachronous occurrence. We demonstrate the simultaneous presence of divergent histological subtypes in a single thyroid gland, with escalating loss of p53 expression in more aggressive variants.Material and methods: A 60-year-old mal...

ea0056p1127 | Thyroid cancer | ECE2018

Incidence of recurrent nerve paresis and hypocalcemia after total thyroidectomy – A retrospective Analysis

Lukas Jindrich , Kuderjavy Tomas , lukas David , Hintnausova Barbora , Drabek Jiri , Syrucek Martin

The aim of this study was to investigate: the incidence of postoperative paresis of the recurrent laryngeal nerve (RLN) and hypocalcemia; the frequency of incidental parathyroidectomy and the occurrence of hypocalcemia, and to find possible risk factors for hypocalcemia and RLN paresis.Material and methods: Retrospective analysis of 550 patients after total thyroidectomy (TT) or completion thyroidectomy (CT) after histologically confirmed thyroid carcino...

ea0056p1128 | Thyroid cancer | ECE2018

Highly sensitive Thyroglobulin assay in monitoring patients treated for differentiated thyoid cancer in 26 consecutive patients

Jimenez Ines , Familiar Cristina , Azcutia Anne , Ramos Elvira , Barrio Elvira

Introduction: Guidelines suggest that serum basal (nonstimulated) thyroblobulin (bTg) with sensitive assays (Functional Sensitivity-FS- below 0.1 or 0.2 ng/ml) could substitute the measurement of serum Tg levels after TSH stimulation during the follow-up of patients with differentiated thyroid cancer (DTC) when basal results fall below the FS.Objective: A sensitive assay for Tg was incorporate in our center (Chemiluminiscent Tg Access; Beckam Coulter; Br...

ea0056p1129 | Thyroid cancer | ECE2018

Hounsfield unit value has null effect on thyroid nodules at 18F-FDG PET/CT scans

Haydardedeoglu Filiz Eksi , Bagir Gulay Simsek , Torun Nese , Kocer Nazim Emrah , Reyhan Mehmet , Ertorer Melek Eda

Objectives: Detection rate of thyroid nodules is increasing with use of new imaging modalities, like 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT). To avoid unnecessary operations, differentiating between benign and malignant 18F-FDG PET/CT-positive thyroid nodules is essential. Many authorities recommend fine needle aspiration biopsy (FNAB) for exclusion of malignancy in thyroid nodules. Although FNAB is a simple, easily performed proc...

ea0056p1130 | Thyroid cancer | ECE2018

Follicular thyroid carcinoma with late metastasis to kidney in a patient with elevated thyroglobulin levels of unknown source

Katkar Rujuta , Shah Manasi , Ryan John A , Odonnell Amy

Here we present a case of follicular thyroid cancer with elevation of thyroglobulin (Tg, in ng/ml) detected almost 10 years after initial surgery and radioactive iodine therapy (RAI). The elevated Tg persisted for years before he was found to have a metastasis in his kidney 16 years after his initial cancer treatment. A 78 year old male had a total thyroidectomy followed by RAI therapy in 2001 for a 2.4 cm follicular thyroid cancer. His Tg became mildly elevated in 2009, and c...

ea0056p1131 | Thyroid cancer | ECE2018

The role of platelet activation and inflammation in patients with differentiated thyroid cancer

Martin Sorina , Ion Oana , Grigore Andreea , Enache Oana , Sirbu Anca , Barbu Carmen , Giulea Cosmin , Miron Adrian , Andrei Florin , Fica Simona

Background: The role of inflammation in the pathogenesis of cancer and the mechanisms through which platelets can influence the aggressive behaviour of different types of cancer have been highlighted by a few studies.Methods: We retrospectively analysed the files of 493 patients submitted to thyroidectomy in our surgery department between 2012 and 2015. We assessed the relationship between differentiated thyroid cancer (DTC) and mean platelet volume (MPV...

ea0056p1132 | Thyroid cancer | ECE2018

Incidental thyroid microcarcinoma in benign thyroid diseases: can it encourage total thyroidectomy as the first choice of surgical treatment? (A retrospective study)

Askitis Dimitrios , Efremidou Eleni I , Giatromanolaki Alexandra , Esebidis Agis , Vamvakerou Vasiliki , Polychronidis Alexandros , Liratzopoulos Nikolaos

Aim: Well-differentiated thyroid cancer (TC) comprises the most common endocrine malignancy, featuring very good prognosis and 5-year survival rate of nearly 100% after total thyroidectomy. However, the prevalence of incidental thyroid microcarcinoma (mITC) is continuously rising during the last decade. One obvious reason is the high prevalence of total thyroidectomy (TT) as the preferred operation for otherwise benign nodular or diffuse thyroid diseases. The current retrospec...

ea0056p1133 | Thyroid cancer | ECE2018

Incidental thyroid microcarcinoma diagnosed after total thyroidectomy for non-toxic solitary thyroid nodule: A 13-year single surgical-center experience (A retrospective study)

Askitis Dimitrios , Efremidou Eleni I , Giatromanolaki Alexandra , Polychronidis Alexandros , Liratzopoulos Nikolaos

Aim: Thyroid cancer (TC) is the most common endocrine malignancy, presenting a rising incidence during the last decade, due to continuously rising prevalence of incidental thyroid microcarcinomas (mITCs; ≤1 cm) in benign thyroid diseases treated with total thyroidectomy (TT). Solitary thyroid nodule (STN) is a thyroid condition, which remains under debate regarding the extent of thyroidectomy needed (total or near-total thyroidectomy vs unilateral lobectomy). Objective o...

ea0056p1134 | Thyroid cancer | ECE2018

The relationship between clinical, morphological and prognostic characteristics of papillary thyroid carcinoma with BRAFV600E mutation assessed immunohistochemically

Sidorin Aleksei , Abrosimov Aleksandr , Rogounovitch Tatiana , Rumyantsev Pavel , Nizhegorodova Kseniya , Isaev Pavel , Shinkarkina Anna , Yamashita Shunichi , Saenko Vladimir

Background: Papillary thyroid carcinoma (PTC), especially its classic papillary, oncocytic, Warthin-like, tall and columnar cell variants, is characterized by a high frequency of BRAFV600E mutation that varies in different studies from 36 to 85%. Prognostic significance of the mutation remains controversial.Objective: Aim of the study was an analysis of relationship between clinical, morphological and prognostic characteristics of PTC with BRAFV600E asse...

ea0056p1135 | Thyroid cancer | ECE2018

Improved prognostic value of the eighth edition of the AJCC/TNM staging system for differentiated thyroid cancer

van Velsen Evert , Stegenga Merel , van Kemenade Folkert , Kam Boen , van Ginhoven Tessa , Visser W Edward , Peeters Robin

Background: In January 2018, the 8th edition of the AJCC/TNM staging system for differentiated thyroid cancer (DTC) was introduced in clinical practice. Studies evaluating this 8th edition so far only comprised patients with papillary thyroid cancer (PTC) or made no distinction between PTC and follicular thyroid cancer (FTC). Therefore, we evaluated the prognostic value of the AJCC/TNM 8th edition in a European population with DTC, and subsequently distinguished PTC and FTC pa...

ea0056p1136 | Thyroid cancer | ECE2018

Quantitative asessments of normal cervical lymph nodes using shear-wave ultrasound elastography

Barajas-Galindo David Emilio , Florencio-Ojeda Luna , Sevillano-Jimenez Maria , Martin-Hernandez Tomas

Purpose: The aim of this study was to evaluate the reference values of quantitative shear wave elastography (SWE) for cervical lymph nodes with normal ultrasound characteristics, and assess if there are differences according the location and other characteristics of patients.Methods: 67 cervical lymph nodes from 52 patients with thyroid nodules that were diagnosed previously as different thyroid disease had been imaged with SWE. The shear elasticity modu...

ea0056p1137 | Thyroid cancer | ECE2018

ABO blood groups, Rh factor and thyroid cancer risk: To ‘B’ or not to ‘B’

Tam Abbas Ali , Ozdemir Didem , Faki Sevgul , Bilginer Muhammet Cuneyt , Ersoy Reyhan , Cakir Bekir

Aim: In this study, we aimed to evaluate ABO blood groups and Rh factor in patients with thyroid cancer. We also assessed whether the ABO/Rh factor had any effect on prognosis, agressive features and advanced stage of thyroid malignancies.Methods: Medical records of patients who underwent thyroidectomy between December 2006 and September 2014 were evaluated retrospectively. Demographical and clinical features, cytological results (according to Bethesda c...

ea0056p1138 | Thyroid cancer | ECE2018

A case of anaplastic thyroid carcinoma complicated with thyrotoxicosis

Hashimoto Daisuke , Nakayama Shuichi , Nishiyama Mitsuru , Fujimoto Shinpei , Terada Yoshio

Background: Anaplastic thyroid carcinoma (ATC), which is one of the most aggressive endocrine tumors. Primary thyroid carcinoma typically does not interfere with thyroid function and presentation of ATC with thyrotoxic state is extremely rare. We present here an ATC patient who is complicated with thyrotoxicosis.Case: A 69-year-old man presented with neck swelling and pointed out thyroid tumor with calcification two years ago. He appeared general fatigue...

ea0056p1139 | Thyroid cancer | ECE2018

Tyrosine kinase inhibitor (TKI) treatment outcome of stage IV-C thyroid differentiated cancer (analyzed by lesion evaluation)

Iwasaki Hiroyuki , Yamazaki Haruhiko , Suganuma Nobuyasu , Sugawara Yuko , Gotoh Naoki , Hatori Shinsuke , Nakayama Hirotaka , Masudo Katsuhiko

Introduction: The standard treatment for differentiated thyroid carcinoma (DTC) with distant metastasis comprises complete total thyroidectomy and lymph node dissection, followed by radioactive iodine (RAI) ablation for metastatic lesions. However, between 2014 and 2015, sorafenib and lenvatinib have been approved for treatment of RAI-refractory advanced thyroid cancer in Japan. We retrospectively analyzed how the treatment results have changed after the approval of tyrosine k...

ea0056p1140 | Thyroid cancer | ECE2018

Expression of VEGFR2 and clinical response of anaplastic thyroid cancer to lenvatinib

Yamazaki Haruhiko , Iwasaki Hiroyuki , Suganuma Nobuyasu , Yokose Tomoyuki , Hayashi Hiroyuki , Osanai Sachie , Masudo Katsuhiko , Nakayama Hirotaka , Kohagura Kaori , Rino Yasushi , Masuda Munetaka

Introduction: Angiogenesis is known to play an important role in the development, growth, and metastasis of carcinomas. The vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) are major molecules involved in angiogenesis. The VEGF family includes seven members, respectively named VEGF-A (often simply denoted as VEGF), VEGF-B, VEGF-C, VEGF-D, VEGF-E, VEGF-F, and placental growth factor. The VEGFR is a tyrosine kinase receptor with one to three types and is activ...

ea0056p1141 | Thyroid cancer | ECE2018

Medullary thyroid carcinoma: a case report on the efficacy and safety of combined treatment with Vandetanib and Lanreotide Autogel

Kalantzi Athanasia , Papanastasiou Labrini , Charalabidou Liana , Lyberopoulos Konstantinos , Kounadi Theodora

Introduction: Treatment options for progressive metastatic unresectable medullary thyroid carcinoma (MTC) include tyrosine kinase inhibitors (TKIs) or somatostatin analogues (SSA), although the efficacy of the latter is debatable. In such cases, combined treatment of TKIs and SSAs has not previously been reported.Aim: To present a metastatic MTC case successfully treated with a combination of Vandetanib and Lanreotide Autogel.Case ...

ea0056p1142 | Thyroid cancer | ECE2018

Increased incidence of thyroid cancer in a spanish tertiary hospital, valladolid, spain: evolution and clinical characteristics, 2002–2016

Calvo Susana Garcia , Diaz-Soto Gonzalo , Sanz Maria Alvarez-Quinones , Martinez-Pino Isabel , Torres Beatriz , Lopez Juan Jose , Mateos Juan Jose , Luis Daniel de

Introduction: Thyroid cancer is the most frequent malignant endocrine neoplasia. Its incidence has significantly risen worldwide in the last decades.Objective: To estimate the incidence of thyroid cancer in Valladolid’s east area population, Spain, over the period 2002–2016.Methods: A retrospective descriptive research was performed in the Clinical Universitary Hospital of Valladolid (HCUVa). Clinical data was obtained fr...

ea0056p1143 | Thyroid cancer | ECE2018

The significance of postoperative calcitonin (CT) levels in the evaluation of disease course in medullary thyroid cancer (MTC) patients

Saltiki Katerina , Simeakis George , Vogiatzi Evangelia , Kassi Eva , Zapanti Evangelia , Alevizaki Maria

Aim: Postoperative calcitonin (postCT) is a prognostic factor for disease progression in MTC patients. We evaluated the disease course in patients with persistently elevated post-CT.Methods: Of all MTC patients (n=273) followed-up in our Unit (for 1–37, median 7 years), 140 (39.3% men, 67.1% sporadicMTCs) had persistently elevated postCT (≥2.0 pg/ml). Clinical and biochemical data were recorded. Patients were classified in four groups...

ea0056p1144 | Thyroid cancer | ECE2018

Changing treatment trends with radioiodine in thyroid carcinoma at the beginning of 21st century in Castilla-La Mancha (Spain)

Delgado Manuel , Sastre Julia , Quiroga Ivan , Gonzalez Javier , Torres Belvis , Aznar Silvia , Alvarez Visitacion , Herranz Sandra , Moreno Jesus , Gomez Paz

Background and objective: The incidence of differentiated thyroid carcinoma (DTC) is increasing worldwide. Radioiodine (RAI) ablation is one of the main elements in the therapy of DTC after surgical removal of the gland. This study aims to compare the use of I131 in a Spanish Cohort of DTC before and after the American Thyroid Association (ATA) 2009 guidelines.Patients and methods: The Cadit-CAM study was designed to evaluate retrospectively characterist...

ea0056p1145 | Thyroid cancer | ECE2018

Chronic lymphocytic thyroiditis is associated with decreased staging of differentiated thyroid cancer

Borowczyk Martyna , Janicki Adam , Dworacki Grzegorz , Szczepanek-Parulska Ewelina , Danieluk Mateusz , Barnett Jonathan , Antonik Magdalena , Kaluzna Malgorzata , Brominska Barbara , Czepczynski Rafal , Beczyk Maciej , Ziemnicka Katarzyna , Ruchala Marek

Introduction: Despite numerous studies, the biological association between chronic lymphocytic thyroiditis (CLT) and differentiated thyroid cancer (DTC) has not been elucidated yet. The aim of the study was to assess whether the presence of CLT exerts any influence on clinical or histological presentation of DTC.Materials and methods: Complete medical records of 907 consecutive patients with DTC treated at a single tertiary care department of endocrinolo...

ea0056p1146 | Thyroid cancer | ECE2018

Clinical characteristics and prognostic factors in patients with follicular thyroid carcinoma

Lorea Ander Ernaga , Bermejo Iranzu Migueliz , Esparza Nerea Eguilaz , Apinaniz Emma Anda , Arribas Javier Pineda , Echarri Ana Irigaray , Garcia Marta Toni , Esteban Juan Pablo Martinez De

Objective: The aim of this study is to evaluate clinical characteristics of patients diagnosed of follicular thyroid carcinoma and to study factors that are associated with a worse prognosis of the disease.Methods: We included 153 patients diagnosed of follicular thyroid carcinoma in our centre between January 1985 and December 2016. The baseline characteristics of the patients, and their long-term outcomes were collected. The mean follow-up was 15.2 yea...

ea0056p1147 | Thyroid cancer | ECE2018

Association between Hashimoto’s thyroiditis and thyroid lymphoma

Banisauskaite Ilona , Barsiene Lina , Pranevicius Robertas , Kuprionis Gintaras , Dauksa Albertas , Rudzianskiene Milda

Introduction: Lymphoma usually occurs within lymph nodes, but in rare cases, it arises from lymphocytes that are presented within the thyroid gland. Thyroid lymphoma is rare, representing less than 5% of thyroid malignancies and less than 2% of all lymphomas occurring outside of the lymph nodes and it is more likely to occur in people with Hashimoto’s thyroiditis. In this case we present a patient with Hashimoto’s thyroiditis (HT) and thyroid lymphom...

ea0056p1148 | Thyroid cancer | ECE2018

Prediabetes and type 2 diabetes mellitus and risk of thyroid cancer

Grimmichova Tereza , Matucha Petr

Background: Increasing incidence of thyroid cancer may be attributable to sensitive diagnostic tools as well as changes in exposure to certain environmental factors. Type 2 diabetes mellitus (DM) reaches high prevalence worldwide. DM is a risk factor for many chronic disorders including cardiovascular disease and cancer. Insulin resistance (IR) is a fundamental aspect of the etiology of DM and compensatory hyperinsulinemia could promote cancer growth. The association between D...

ea0056p1149 | Thyroid cancer | ECE2018

The mitochondrial DNA control region might have useful diagnostic and prognostic biomarkers for thyroid tumors

Bircan Rifat , Gozu Hulya Iliksu , Ulu Esra , Sarikaya Sukran , Sirin Duygu Yasar , Ozcelik Serhat , Aral Cenk

Background: It is currently present in the literature that mitochondrial DNA (mtDNA) defects are associated with a great number of diseases including cancers. The role of mitochondrial DNA (mtDNA) mutations/variations in the development of thyroid cancers is a highly controversial topic. In this study, we aimed to investigate the role of mt-DNA control region (CR) variations in thyroid tumor occurrence and the influence of mtDNA haplogroups on susceptibility t...

ea0056p1150 | Thyroid cancer | ECE2018

Papillary carcinoma detected incidentally in a patient with Graves’ disease

Alaguney Elif Sevil , Yorulmaz Goknur , Yilmaz Evrim , Badak Bartu , Kebapci Nur , Akalin Aysen

Introduction: Graves’ disease is an autoimmune thyroid disease presenting with hyperthyroidism. In Graves’ disease, there may be diffuse enlargement in the thyroid gland, as well as nodular appearance. The risk of papillary carcinoma should always be kept in mind while the risk of malignancy is low in Graves’ disease.Case presentation: A 50-year-old woman was admitted to our center for a second-time exacerbation of hyperthyroidism in 2015....

ea0056p1151 | Thyroid cancer | ECE2018

Determination of the BRAF V600E mutation prevalance at papillary thyroid carcinomas (PTCs) in Turkish population

Ozcelik Serhat , Bircan Rifat , Sarikaya Sukran , Aydin Busra , Celik Mehmet , Dayan Akin , Karadayi Nimet , Tutuncu Yasemin , Cengiz Hasret , Ozcelik Melike , Gozu Hulya Iliksu

Introduction: BRAF V600E substitution is one of the most common mutation in PTC in different populations, and is associated with poor prognosis of the classical variant of PTC (CVPTC) such as extrathyroidal expansion, vascular invasion, lymph node metastasis and recurrence of the disease. The purpose of this study is to determine the prevalence of BRAF V600E mutation in subcell- types of the PTCs in Turkish population.Materials and methods: A total of 19...

ea0056p1152 | Thyroid cancer | ECE2018

Association between Ospital ng Makati-based thyroid ultrasonography descriptive findings and fine-needle aspiration biopsy with histopathology in the diagnosis of thyroid malignancies

Antonio Bautista Jose , Allyn Sy Rosa , Sapang Buena , Cipriano Chritopher

Statement of the problem: Thyroid nodules are one of the most common clinical problems encountered today. Detection of these nodules have been augmented with ultrasonography and fine needle aspiration biopsy (FNAB). Worldwide, the use of international standards of reporting such as the American Thyroid Association (ATA) Sonographic Pattern Risk Assessment and the Bethesda System for Reporting Thyroid Cytopathology have been proven to detect thyroid malignancies. However, ultra...

ea0056p1153 | Thyroid cancer | ECE2018

Thyroid gland metastasis from a laryngeal mucinous adenocarcinoma: a case report

Gayle Galang Daphne , Ang-Golangco Nerissa , Ray Richard Cedeno Joseph

Introduction: Despite its high vascularity, metastases to the thyroid is rare. The frequency of metastasis in routine practice is less than 0.2% of thyroid malignancies.Clinical case: An ambulatory 48-year-old male presented with a two-month history of enlarging anterior neck mass that moves with deglutition, slowly growing in size, associated with hoarseness later in the course of the disease. He had no pertinent past medical history. Fine needle aspira...

ea0056p1154 | Thyroid cancer | ECE2018

Circulating thyroid autoantibodies are more sensitive than fine needle aspiration in detecting metastatic thyroid cancer

Ferrari Federica , Agate Laura , Latrofa Francesco

Introduction: Follow up of differentiated thyroid cancer requires periodic measurements of thyroglobulin (Tg) and Tg autoantibodies (TgAb) and neck ultrasound. Recurrence is suspected in presence of rising levels of Tg and/or TgAb. Positive cytology or detectable Tg in washout of fine needle aspiration (FNA) of neck lymph nodes or 131-I neck uptake confirm the diagnosis of metastatic lymph node.Case report: We report on a 25 year-old Caucasian man, affec...

ea0056p1155 | Thyroid cancer | ECE2018

Are there any differences between hot and cold nodules according to cytology and histopathology results?

Baser Husniye , Topaloglu Oya , Cuneyt Bilginer Muhammet , Ulusoy Serap , Kilicarslan Aydan , Ozdemir Elif , Ersoy Reyhan , Cakir Bekir

Introduction: Many recent studies have shown that detection of an incidental thyroid cancer among patients operated for a toxic thyroid disease is not infrequent. We aimed to compare cytology and histopathology results of cold, warm and hot nodules in patients who had thyroidectomy due to toxic multinodular goiter (TMNG).Methods: The cytology, histopathology and scintigraphy records of 1069 thyroid nodules from 413 patients who had operation with TMNG we...

ea0056p1156 | Thyroid cancer | ECE2018

Diagnostic accuracy of CNB in tyroid nodules smaller than 1 centimeter

Paja Miguel , Ugalde Aitziber , Korta Igone , Zabala Rosa , Martinez Adela L , Zabalegui Alba , Arrizabalaga Cristina , Calles Laura A , Etxebarria Eider , Del Cura Jose L

Current guidelines suggest sonographic follow-up in thyroid nodules smaller than 10 mm with intermediate or highly suspicious features as ultrasound-guided FNAC has poor results in these nodules, and the risk of non-diagnosed thyroid carcinoma is very low. CNB has proved superior to repeated FNAC in case of insufficient or indeterminate first FNAC.Objective: Evaluate diagnostic accuracy of CNB in nodules smaller than 10 mm with intermediate or high suspi...

ea0056p1157 | Thyroid cancer | ECE2018

Serum thyroglobulin (sTg) before surgery in euthyroid patients with differentiated thyroid cancer (DTC)

Paja Miguel , Lizarraga Aitzol , Exposito Amaia , Teresa Gutierrez M , Barrios Borja , Iglesias Natalia C , Zabalegui Alba , Arrizabalaga Cristina , Martinez Adela L , Oleaga Amelia

sTg is universally accepted as the best marker of disease status in DTC. Its presurgical serum level may suggest the presence of distant metastasis in case of very high level, but the correlation between its level and the characteristics of the tumour is yet to be defined.Objective: To evaluate preoperative thyroglobulin as predictor of DCT features.Methods: Preoperative sTg was measured in patients operated for DTC between 2011&#1...

ea0056p1158 | Thyroid cancer | ECE2018

Coexistence of papillary thyroid carcinoma and autoimmune thyroid disease

Sakka Imen , Oueslati Ibtissem , Chihaoui Melika , Chaker Fatma , Yazidi Meriem , Rejeb Ons , Slimane Hedia

Introduction: Papillary thyroid carcinomas (PTC) represent up to 87% of all thyroid cancers with an incidence that has doubled over the past 30 years. Hashimoto’s thyroiditis (HT) and Graves’ disease are two autoimmune thyroid diseases representing the most common causes of hypothyroidism and hyperthyroidism, respectively. Although PTC with coexisting HT has been reported in literature, its association with GD is not a common condition. Herein, we report three cases ...

ea0056p1159 | Thyroid cancer | ECE2018

Analysis of the prognostic factors during I-131 therapy for differentiated thyroid cancer patients using BIOMAT ENDO data base

Purice Mariana , Andreea Chiriac Iulia , Radulescu Monica , Livia Gheorghiu Monica , Goldstein Andrei-Liviu

BIOMAT-ENDO software is a Windows Forms application that stores all the main data regarding the patients with thyroid cancer (TC) hospitalized in the Nuclear Medicine Department of the National Institute of Endocrinology in Bucharest, starting with the first hospitalization, continuing with the periods of radioiodine therapy (RIT) and the follow up. Patient-monitoring MODULE contains clinical parameters, surgery details, in Vivo and in Vitro investig...

ea0056p1160 | Thyroid cancer | ECE2018

Treatment strategies in medullary thyroid carcinoma – outcome following initial surgery with a curative, debulking or prophylactic intent

Mitravela Vasiliki-Ioanna , Glynn Nigel , Waterhouse Mona , Akker Scott , Korbonits Marta , Drake William , Berney Daniel , Plowman Nick , Carpenter Robert , Parvanta Laila , Druce Maralyn

Medullary thyroid carcinoma (MTC) is a rare malignancy which has often metastasised at time of diagnosis. Surgical resection represents the only prospect for cure. However, debulking neck surgery may be beneficial in advanced cases. Prophylactic surgery is increasingly undertaken in asymptomatic patients with known mutations in the RET oncogene. The aim was to describe the outcome following initial surgical treatment for MTC at our institution. We performed a retrospe...

ea0056p1161 | Thyroid cancer | ECE2018

Thyroid cancer prevalence and pathological features in thyroidectomy patients – five years experience

Enache Oana-Stefana , Martin Sorina , Ion Oana , Grigore Andreea , Bojoga Irina , Parfeni Ovidiu , Sirbu Anca , Barbu Carmen , Giulea Cosmin , Miron Adrian , Andrei Florin , Fica Simona

Objectives: In the last decades, thyroid cancer incidence has increased all over the world. This may be due to heightened medical surveillance and more addressability to surgery, as many cancers are diagnosed while under 1 cm. The aim of our study was to obtain data about the prevalence and histological subtypes of primary thyroid carcinoma in patients undergoing thyroidectomy.Materials and methods: We retrospectively analysed the files of 953 patients w...

ea0056p1162 | Thyroid cancer | ECE2018

A case of familial follicular thyroid carcinoma

Bouchenna Amira , Ghennam Brahim , Kaci Sarah , Chikh Assya , Brakni Lila , Khodja Moussa Nacer , Heffaf El Mehdi , Kablia Samia Ould

Introduction: Familial follicular cell-derived tumors may account 5–15% of thyroid carcinoma cases. Defined as the attainment of two or more first-degree relatives by thyroid cancer in the absence of a known familial syndrome. When three or more family members are affected, the probability that the disease has a familial origin is 99.9%. We report the case of a family of 4 siblings affected.Observation: – Patient aged 43 years, without a person...

ea0056p1163 | Thyroid cancer | ECE2018

Co-incidence of medullary and papillary thyroid carcinoma

Tirnova Zelal Sahin , Sisman Pinar , Gul Ozen Oz , Cander Soner , Ersoy Canan , Erturk Erdinc

Introduction: Papillary thyroid carcinoma (PTC) is the most common thyroid carcinoma and is derived from thyroid follicular cells which originate from the endodermal origin. In contrast, medullary thyroid carcinoma (MTC) is rare and originates from the parafollicular C-cells, which are commonly thought to be derived from the ectodermal neural crest. Co-incidence of the two condition on the same patient is so rare. We describe a case of concurrent MTC and PTC occurring in the s...

ea0056p1164 | Thyroid cancer | ECE2018

The prevalence of concomitent non-medullary thyroid carcinoma and primary hyperparathyroidism

Teodoriu Laura , Balaceanu Raluca , Ungureanu Maria-Christina , Leustean Letitia , Grigorovici Alexandru , Danila Radu , Ciobanu Gabriela-Delia , Stefanescu Cipriana , Preda Cristina

Introduction: Synchronous medullary thyroid cancer and pHPT is common in MEN-2A (Sipple syndrome). In contrast, concomitant nonmedullary thyroid cancer and primary hyperparathyroidism (PHPT) is very rare even if the pathological relationship between parathyroid and thyroid diseases is common.Aim: Was to determine the prevalence of non-medullary thyroid carcinoma in patient who underwent neck exploration for PHPT.Patients and method...

ea0056p1165 | Thyroid cancer | ECE2018

Visualization of Hepatic Metastases of Medullary Thyroid Carcinoma on Tc-99 Bone Scintigraphy

Mezoued Mouna , Habouchi Amine , Meskine Djamila

Medullary carcinoma of the thyroid (MCT) is a tumor developed at the expense of the thyroid parafollicular cells, and secretes the polypeptide hormone calcitonin. It is known as an aggressive tumor that metastasizes early. Case Report: We describe a case of a 57 year-old women, who presented a neck mass, for which she underwent a total thyroidectomy associated to a bilateral neck dissection and was diagnose as MCT. Post operatively calcitonin remained elevated (19000 pg/ml). C...

ea0056p1166 | Thyroid cancer | ECE2018

Descriptive analysis of papillary thyroid microcarcinomas in a single-center

Gonzalez Elena Fernandez , Moreno Isabel Huguet , Munoz Jose Luis , Moreno Nerea Aguirre , Peris Begona Pla , Sanchez Clara Marijuan , Castro Marta Araujo , Ramos-Levi Ana , Azpiroz Monica Marazuela , Ramirez Manuel Luque , Vargas Marcos Lahera

Introduction: The incidence of papillary thyroid microcarcinomas (MPT, max diameter≤10 mm) has increased in recent years. Most have a very good prognosis but some have growth during follow-up, lymph node and / or distant metastases.Material and methods: We performed a single-center, retrospective cohort study, n=114 patients (86% women, average age 48.3 years), diagnosed with MPT between 1998 and 2012. Risk stratification system (ATA 2015): 10 high...

ea0056p1167 | Thyroid cancer | ECE2018

TSH level and risk of malignancy in patients with thyroid nodules with Bethesda IV Cytopathology System

Moujir Carolina Fernandez-Trujillo , Perez Carlos Antonio Rodriguez , Arencibia Dunia Marrero , Plasencia Yaiza Lopez , Zaballo Julio Perez , Galvan Jose Cabrera , Mogollon Francisco Javier Novoa , Cortes Mauro Boronat

Introduction: Fine needle aspiration biopsy (FNAB) is the mainstay diagnostic procedure for evaluation of thyroid nodules, but it doesn’t permit to distinguish between benign and malignant follicular lesions (category IV in the Bethesda Cytopathology System). Some reports have suggested an association between increased serum levels of TSH and thyroid cancer. However, the specific relationship between TSH and malignancy has been scarcely studied in follicu...

ea0056p1168 | Thyroid cancer | ECE2018

A review of prevalence, reporting, and criteria for further investigation of incidental thyroid nodules reported on computed tomography scanning in an Irish general hospital

Brazil John , Sharma Jayant

The purpose of this study was to identify the prevalence of Incidental Thyroid Nodules (ITN’s) on Computed Tomography (CT) scans of the chest, assess variation in reporting by radiologists and to apply recent guidance to assess which nodules may require further investigation. We performed a retrospective review of 742 CT scans which included the chest performed in a regional hospital. Thyroid abnormalities were reported in 9.8% (n=76) of CT scans. There was consi...

ea0056p1169 | Thyroid cancer | ECE2018

A review of histology reports of 675 thyroid cancer cases in a single centre over ten years

McVeigh Niall , Khattak Aftab , Toner Mary , O'Regan Esther , Healy Marie-Louise

The recently (2015) revised American Thyroid Association guidelines for the management of differentiated thyroid cancer recognise the importance of histological subtype in risk stratification. The prevalence of thyroid cancer subtypes in an Irish population is unknown. We reviewed all histology reports of thyroid carcinoma from a quaternary referral centre over a 10 year period, 2005 to 2015. 675 reports were reviewed. Of these, 87% were reported as papillary thyroid cancer (P...

ea0056p1170 | Thyroid cancer | ECE2018

Evolution of tumor markers after external beam radiotherapy in the non-undifferentiated thyroid cancer

Moragrega Raquel Miralles , Freixes Maria Maria Curras , Zelaya Carolina Perdomo , Vaamonde Javier Gargallo , Valero Maria Llavero , Jimenez Marta Moreno , Galofre Juan C

Introduction: The role of external beam radiotherapy (EBRT) as primary or as adjuvant therapy in the non-undifferentiated thyroid cancer (NUTC) is controversial. Most published data refer to retrospective case series. Therefore, little is known about the correlation between tumor markers and radiologic measurements of tumor response.Objectives: The study aimed to analyze the kinetics of tumor markers and radiologic measurement of tumor response after EBR...

ea0056p1171 | Thyroid cancer | ECE2018

Natural course of thyroid cancer nodules compared with benign thyroid nodules

Baek Ki-Hyun , Kang Moo-Il , Yoon Kyung-Jin

Purpose: The primary aim of this study was to evaluate changes in the diameter and volume of thyroid cancer nodules identified using fine-needle aspiration biopsy (FNAB) or surgery, and to compare the changes in size between thyroid cancer nodules and benign nodules. The secondary aim was to analyze the risk factors associated with thyroid cancer nodule growth.Methods: A total of 96 patients with 102 nodules were enrolled in the cancer group, and 98 pati...

ea0056p1172 | Thyroid cancer | ECE2018

Risk of thyroid malignancy in large thyroid nodules greater than 4 cm

Yoon Jee Hee , Kim Hee Kyung , Kang Ho-Cheol

Background: The risk of thyroid cancer in large thyroid nodules greater than 4 cm has been reported to be increased. Some authors insist that diagnostic lobectomy should be performed in patients with large thyroid nodules, irrespective of fine needle aspiration cytology (FNA) results. However, consensus on that matter has not been met. We wanted to investigate the risk of thyroid malignancy according to the size of the thyroid nodules, based on FNA results.<p class="abstex...

ea0056p1173 | Thyroid cancer | ECE2018

Relationship between microRNA expression levels and tumor size in patients with papillary thyroid carcinoma

Pamedytyte Daina , Simanaviciene Vaida , Zvirbliene Aurelija , Kazokaite Mintaute , Sarauskas Valdas , Dauksiene Dalia , Dauksa Arbertas , Zilaitiene Birute

Introduction: Despite low mortality rates of patients with papillary thyroid carcinoma (PTC), disease progression in PTC occurs in up to 20% of patients. Currently, recurrence risk stratification is accomplished by using clinicopathologic factors, despite their limited prognostic value. Some data suggest that patient age at disease onset and primary tumor size may predict the risk of disease progression. Identification of possible associations of traditional clinicopathologica...

ea0056p1174 | Thyroid cancer | ECE2018

Correlation of preablative thyroglobulin to the new response to therapy system in differentiated thyroid cancer

Siolos Athanasios , Exadaktylou Paraskevi , Papadopoulos Nikitas , Poimenidou Irini , Rakitzi Pantelitsa , Tziomalos Konstantinos , Chatzipavlidou Vasiliki , Pazaitou-Panayiotou Kalliopi

Introduction: Evidence supports the prognostic value of preablative stimulated thyroglobulin (ps-Tg) for recurrent and persistent disease in patients with differentiated thyroid cancer (DTC). The correlation of ps-Tg with therapeutic response however has been less studied.Objective: To study the correlation of ps-Tg and the trend of serial preablative thyroglobulin measurements(DTg) with the response to treatment restaging system proposed in 2015 America...

ea0056p1175 | Thyroid cancer | ECE2018

May hemocytometer parameters be a biomarker in medullary thyroid carcinomas?

Sisman Pinar , Bicer Buket , Oztop Hikmet , Cander Soner , Oz Gul Ozen , Ersoy Canan , Erturk Erdinc

Aims: Medullary thyroid carcinoma (MTC) is a rare endocrine cancer that accounts for approximately 5% of all thyroid cancers. Both the diagnosis and management of MTC could be difficult. Surgery is a main therapy in MTC, chemotherapy and external radiotherapy have limited efficacy. Recently, the relationship between some of the hemocytometer parameters and cancer has been investigated. In this study we aimed to determine the relationship between MTC and hemocytometer parameter...

ea0056p1176 | Thyroid cancer | ECE2018

131I-MIBG as a treatment in medullary thyroid carcinoma with distant metastases.

Uriarte Nerea Utrilla , Fernandez Pedro Gonzalez , Figueruelo Alba Esteban , Herrero Marina Nevares , Sandi Javier Santamaria

Introduction and objectives: The strategies for therapy of metastatic medullary thyroid carcinoma (MTC) are limited. Although Tyrosine kinase inhibitors (TKI) seem to be the first-line treatment, we want to explore other possibilities. Metaiodobenzylguanidine (MIBG) is a guanethidine derivative, structurally similar to norepinephrine. It was developed as an imaging agent with 123I radiolabeling. MIBG localizes neuroendocrine tumors including MTC. We are investigatin...

ea0056p1177 | Thyroid cancer | ECE2018

Role of the fine-needle aspiration biopsy of cervical lymph nodes with thyreoglobulin washing tests in management patients with differentiate thyroid cancer.

Galczynski Jacek , Bakula-Zalewska Elwira , Dedecjus Marek

The aim of this study was the assessment of diagnostic utility of fine-needle aspiration biopsy needle washout fluids (FNAB-Tg) in the cases of thyroid carcinoma recurrence and analysis of false-positive and false-negative results.Methods: Two hundred and fifteen FNAB-Tg samples from 201 patients with a history of differentiated thyroid carcinoma with suspicious lymph nodes were included in analysis. The wash-out of needle rinsed with 0.5ml of normal sal...

ea0056p1178 | Thyroid cancer | ECE2018

Malignancy risk stratification of thyroid nodules with cytological diagnosis of folicular neoplasm (Bethesda IV), according to the ultrasound sonographic patterns proposed by the American Thyroid Association (ATA)

Pineda Jose Javier , Ernaga Ander , Anda Emma , Toni Marta , Martinez Juan Pablo , Munarriz Patricia , Rojo Jorge , Ollero Dolores , Diaz Maria

Background: The main limitation of fine-needle aspiration (FNA) is represented by indeterminate category (Bethesda III and IV) in which the risk of malignancy is between 5-30%. Given this result, surgical treatment is necessary in many cases. The aim of our study is to assess whether the ultrasound patterns proposed by the ATA, help us to stratify the risk of malignancy in nodules with Bethesda IV cytology result.Methods: From January 2011 to June 2017 w...

ea0056p1179 | Thyroid cancer | ECE2018

A rare case of mixed medullary and papillary thyroid carcinoma related with heterozygous VAL804MET mutationa rare case of mixed medullary and papillary thyroid carcinoma related with heterozygous VAL804MET mutation

Guler Bagdagul Yuksel , Faki Sevgul , Aydin Cevdet , Yalcin Abdussamed , Yavuz Huban Sibel Orhun , Ersoy Reyhan , Cakir Bekir

Introduction: Papillary thyroid carcinoma(PTC) and medullary thyroid carcinoma(MTC) have always been considered different tumors. Concomitant presence of MTC and PTC in the same patient is a rare clinical event.Case report: A 43 year-old woman admitted with fatigue, a serum thyrotropin of 4.6 uIU/ml and a 15×11 mm thyroid nodule in right lobe detected in another center. Fine needle aspiration(FNA) of the nodule was consistent with MTC. In family his...

ea0056p1180 | Thyroid cancer | ECE2018

Validity of sonographic pattern risk in thyroid nodules by the American Thyroid Association (ATA) and citological malignancy diagnosis

Anda Emma , Pineda Javier , Eguilaz Nerea , Irigaray Ana , Ernaga Ander , Toni Marta , Martinez Juan Pablo , Ollero Dolores , Almudevar Elena

Objetive: The aim of our study is to asses the validity of ultrasound patterns proposed by the ATA and malignancy risk in the cytological diagnosis classified by the Bethesda System.Methods: Prospective study including all thyroid nodules (with no previous cytological results), assessed in our center from July/2016 to June/2017. We classified nodules in ATA sonographic risk patterns and follow-up its fine needle aspiration (FNA) recommendations. The stat...

ea0056p1181 | Thyroid cancer | ECE2018

The role of thyroid imaging, reporting and data system scores – ACR TI-RADS in thyroid nodular disease – our expirience

Icin Tijana , Prodanovic Jovana , Bajkin Ivana , Slankamenac Sonja , Novakovic-Paro Jovanka , Tomic Dusan , Popovic Dore , Pejakovic Slaana , Tesic Dragan , Stokic Edita , Mitrovic Milena

Introduction: The American College of Radiology proposed in 2017. ACR-TIRADS scoring system for the ultrasound findings of the thyroid gland. It now represents a standardized system of scoring pathological changes determined from five categories registered with ultrasound. High cumulative result leads to higher TR level and the higher probability of malignancy, which provides recommendations for eather FNA (fine needle aspiration) or further ultrasound monitoring of nodules as...

ea0056p1182 | Thyroid cancer | ECE2018

May cinacalcet improve psychiatric symptoms by decreasing calcium levels in lithium-associated hyperparathyroidism?

Faki Sevgul , Aydin Cevdet , Polat Sefika Burcak , Ozdemir Didem , Bilginer Muhammet Cuneyt , Ersoy Reyhan , Cakir Bekir

Introduction: Lithium is the preferred and most efficacious therapy for acute and maintenance therapy of bipolar depressive disorder. Lithium use is associated with an increased incidence of hyperparathyroidism (4.3–6.3%) and have a female preponderance. Bilateral neck exploration was the most common surgical approach while a few patients were managed medically. The initial management of Lithium-associated hyperparathyroidism (LAH) is medical intervention which includes d...

ea0056p1183 | Thyroid cancer | ECE2018

Pediatric thyroid cancer is associated with more aggressive phenotype and more frequent RET/PTC rearrangements compared with the adult patients

Bendlova Bela , Sykorova Vlasta , Dvorakova Sarka , Vaclavikova Eliska , Pekova Barbora , Katra Rami , Kodetova Daniela , Lastuvka Petr , Plzak Jan , Bavor Petr , Hoch Jiri , Vlcek Petr , Sykorova Pavla , Vcelak Josef

Thyroid cancer in children and adolescents is a rare disease but with an increasing incidence. As in adults, the most prevalent type is papillary thyroid carcinoma (PTC). Our aim was to describe the clinical and genetic comparison between pediatric and adult PTC. We analyzed the cohorts of 73 pediatric PTC (5-18 years, female to male ratio 2.3:1, 10 patients <10 years) and 460 adult PTC patients. DNA and RNA were extracted from cancer tissue samples. DNA was used for seque...

ea0056p1184 | Thyroid cancer | ECE2018

Serum osteopontin levels in newly diagnosed thyroid cancers

Kars Taha Ulutan , Kulaksizoglu Mustafa

Purpose: Thyroid cancer is the most common cancer of endocrine system. Osteopontin (OPN) is a secreted glycoprotein that has a role in osteoblast differentiation and bone formation. Osteopontin has other roles in cell migration and cell survival and its related to tumorigenesis and cell invasion. Osteopontin levels have been determined higher in some malignancies. The purpose of this study is to determine plasma osteopontin levels in patients with new onset diagnosed thyroid c...

ea0056p1185 | Thyroid cancer | ECE2018

First report of c.1683A>G FLT3 mutation found in the follicular thyroid cancer

Borowczyk Martyna , Szczepanek-Parulska Ewelina , Debicki Szymon , Budny Bartlomiej , Janicka-Jedynska Malgorzata , Wrotkowska Elzbieta , Majchrzycka Blanka , Ziemnicka Katarzyna , Ruchala Marek

Introduction: The number of thyroid cancer diagnosis has increased worldwide. However, its diagnosis, particularly in a case of follicular cancer (FTC), may be challenging. New markers of malignancy are intensively searched for.Case description: A 29-year-old female was referred for subtotal thyroidectomy in 2006 due to a nodule in the right lobe. The histopathological examination revealed follicular adenoma (FA). During endocrinological follow-up, in 20...

ea0056p1186 | Thyroid cancer | ECE2018

Thyroglossal duct cyst papillary carcinoma: case report and review of literature

Delgado M , Paz J , Linares E , Gonzales J , Lopez R , Ponce A , Cabrera F , Calderon K , Regalado S , Casusol J , Castro M , Reano C , Giles I , Corrales J , Saenz S , Rojas Marialejandra Delgado , Reyes Edgardo Linares , Ibarra Jose Luis Paz

Objective: To report a rare case of papillary thyroid carcinoma (PTC) in a thyroglossal duct cyst (TGDC).Case report: A 34-year-old peruvian male came to our hospital with a complaint of a swelling cervical mass in the anterior central side of the neck, which was growing since 6 months earlier. The patient had no significant past medical, surgical history and was completely asymptomatic. He denied any family history of thyroid disease or history of head ...

ea0056p1187 | Thyroid cancer | ECE2018

Thyroid imaging reporting and data system: how useful is it in distinguishing follicular adenomas from follicular carcinomas?

Santos Francisco Sousa , Saraiva Catarina , Capitao Ricardo , Ferrinho Catia , Limbert Clotilde , Chorao Martinha , Ramos Sancia , Vasconcelos Carlos

Introduction: Various thyroid imaging reporting and data systems (TIRADS) have been proposed in recent years, such as the EU-TIRADS proposed by the European Thyroid Association (ETA). These classification systems intend to estimate the malignancy risk of thyroid nodules, however they are very much based on suspicious ultrasound (US) features typical of papillary thyroid cancer. As such, follicular carcinomas may be reported as low suspicion nodules. Our work aims to evaluate t...

ea0056p1188 | Thyroid cancer | ECE2018

Descriptive study about clinical and surgical characteristics of patients with differentiated thyroid cancer in our health area

Gonzalez Javier , Calderon Dulce Maria , Marton David , Al-Ramadan Mubarak , Perez Jose

Introduction, material and methods: Differentiated thyroid cancer is a pretty common reason for consulting in our specialty. In general terms, the prognosis is good in the main histological type but there are many others that can worsen the prognosis. It can determine the kind of surgery from hemithyroidectomy (e.g. microcarcinoma) to no intervention because of its extension at the moment of diagnosis. We have collected the data of our patients with differentiated thyroid canc...

ea0056p1189 | Thyroid cancer | ECE2018

Thyroid ultrasonography and fine needle aspiration: a center experience

Catarino Diana , Ribeiro Cristina , Oliveira Diana , Martins Diana , Lages Adriana , Ventura Mara , Cunha Nelson , Fadiga Lucia , Marques Bernardo , Melo Miguel , Paiva Sandra , Carrilho Francisco

Introduction: Thyroid ultrasonography and fine needle aspiration (FNA) are the most useful techniques in the evaluation of thyroid nodules. They are cheap, fast, minimally invasive and high precision methods. The FNA can be performed by palpation or ultrasound guidance. The use of ultrasound reduces the nondiagnostic results rate. However, the cytologic diagnostic accuracy depends on the technique and pathologist experience. Ultrasonography confirms the presence of a thyroid n...

ea0056p1190 | Thyroid cancer | ECE2018

Brain metastases from papillary thyroid carcinoma, 31 years later

Catarino Diana , Saraiva Joana , Ribeiro Cristina , Oliveira Diana , Martins Diana , Lages Adriana , Ventura Mara , Cunha Nelson , Fadiga Lucia , Marques Bernardo , Donato Sara , Melo Miguel , Corbal Maria , Reis Inacio , Carrilho Francisco

Introduction: Papillary thyroid carcinoma (PTC) is a differentiated thyroid carcinoma and is the most common variant. It is more frequent in women and the median age at diagnosis is 45 years. Most PTC are clinically indolent, have a good prognosis and low incidence of distant metastases. The more frequent locals of distant metastases are bone and lung. Brain metastases are very rare and associated with a poor prognosis.Case report: We present a case of a...

ea0056p1191 | Thyroid cancer | ECE2018

Ectopic thyroid tissue challenge: clinical case report

Verissimo David , Ivo Catarina , Duarte Vitoria , Passos Dolores , Serra Filipa , Silva Joao , Lopes Luis , Castro Joao Jacome de , Marcelino Mafalda

Introduction: Ectopic thyroid tissue is a rare embryonic developmental defect that occurs during the thyroid transition from its initial position in the floor of the primitive bowel to a pre-tracheal location. This defect has a prevalence in the general population of 0.3–1/100,000 inhabitants, increasing to 0.5–1/4,000 patients with thyroid pathology. It is more common in women and can be diagnosed at any age, with diagnosis being more common in young individuals.</p...

ea0056p1192 | Thyroid cancer | ECE2018

Tyrosine kinase inhibitors in iodine-refractory thyroid cancer. Clinical experience

Marijuan Clara , Pla Begona , Aguirre Nerea , Fernandez Elena , Hernando Inigo , Jimenez Sara , Marazuela Monica , Lahera Marcos

Introduction: Tyrosine kinase inhibitors (TKIs) are used for treatment of iodine-refractory differentiated thyroid cancer (DTC) in patients with progressive advanced disease.Sorafenib and lenvatinib are the TKIs currently approved for this indication.Objective: To describe the clinical experience in patients with iodine-refractory DTC treated with TKIs in our Institution.Materials and methods: Restrospective cohort study of patient...

ea0056p1193 | Thyroid cancer | ECE2018

Correlation between TSH level and benignity and malignancy of thyroid nodules (about 250 cases)

Zahra Iftahy Fatima , El Aziz Siham , Chadli Asma

Background: Plasma TSH is a fundamental marker of thyroid function. The TSH level might be different depending on nodule’s type. Recent studies have shown a relationship between plasma TSH levels and thyroid nodules malignancy. The aim of this study was to compare the TSH level between two groups of subjects who had undergone total thyroidectomy, one group whose final histology was benign and one group who had a malignant histology.Materials and met...

ea0056p1194 | Thyroid cancer | ECE2018

Efficacy and toxicity of lenvatinib treatment for radioiodine refractory thyroid cancer in daily clinical practice: a single centre experience

Prieto Lucia , Ferreira Carvalho Rui , Oses Virginia , Blanco Concepcion , Palacios Nuria , Aller Javier

Introduction: Lenvatinib is a multitarget tyrosine kinase inhibitor that has shown substantial efficacy in patients with progressive radioiodine refractory thyroid cancer (RAIRDTC) (progression free survival (PFS) 19.4 months and objective response rate 64.8%; SELECT trial) despite common adverse events (AEs).Objective: To evaluate efficacy and toxicity of lenvatinib treatment for RAIRDTC in daily clinical practice.Methods: Retrosp...

ea0056p1195 | Thyroid cancer | ECE2018

Comparative study about clinical characteristics at the moment of surgery and follow-up depending of histological type in patients with differentiated thyroid cancer in our health area

Gonzalez Javier , Maria Calderon Dulce Alramadan Mubarak , Martin David , Maria Calderon Dulce

Introduction, material and methods: Papillary thyroid cancer is well known to be a tumour with a good prognosis; in spite of that, it usually presents many recurrences that increases its morbidity. Follicular thyroid cancer is less frequent but has a higher rate of hematogenous dissemination and higher mortality than papillary thyroid cancer. We have collected the data of our patients with differentiated thyroid cancer during the period from 2000 to 2015. In this study, we hav...

ea0056p1196 | Thyroid cancer | ECE2018

Insular carcinoma of the thyroid diagnostic and prognostic evaluation

Zahra Iftahy Fatima , El Aziz Siham , Chadli Asma

Background: Insular carcinoma of the thyroid is an extremely rare tumor (4% of cases) with a poor prognosis and an intermediate malignancy between differentiated and anaplastic cancers. The aim of this study was to define the particular points of this cancer by studying its diagnostic and prognostic aspects.Materiel et methods: Retrospective study was conducted in Endocrinology and diabetology department of Ibn Rochd University Hospital of Casablanca, in...

ea0056p1197 | Thyroid cancer | ECE2018

Amiodarone – thyrotoxicosis and thyroid cancer

Cristina Taujan Georgiana , Simona Dragomir Adina , Maria Dumitru Alina , Olaru Maria

Introduction: Although thyrotoxicosis is considered to be a very rare finding in a patient with thyroid cancer, there are several reports regarding this unexpected association in specialty literature. A frequent cause of thyrotoxicosis in patients with cardiac disease is amiodarone-induced thyroid dysfunction. The mechanism underlying this adverse reaction can be attributed to high iodine content and the direct toxic effect of the drug on thyroid cells.C...

ea0056p1198 | Thyroid cancer | ECE2018

Thyroid carcinoma in adolescents and young adults (about 120 cases)

Zahra Iftahy Fatima , El Aziz Siham , Chadli Asma

Background: Differentiated adolescent and young adult thyroid cancers are under diagnosed. They would be characterized by their aggressiveness and the presence of particular histological forms. The aim of the study was to define the particular points of thyroid carcinoma in this population by analyzing the clinical, histological and therapeutic characteristics.Materials and methods: A case-control study was conducted in the endocrinology and diabetology ...

ea0056p1199 | Thyroid cancer | ECE2018

Anaplastic thyroid cancer: a diagnostic and therapeutic challenge

Mirica Alexandra , Petris Rodica , Mirica Radu , Paun Sorin , Badiu Corin , Paun Diana

Introduction: Thyroid cancer incidence has registered an important increase in the last years. Anaplastic thyroid cancer represent a rare malignancy with an aggressive biological behavior and a high mortality rate.Case presentation: We present the case of a 69-years-old woman who addressed our department for endocrine evaluation in the context of a right latero-cervical lymph nodes, complaining of mixed dysphagia and dyspnea, that developed progressively...

ea0056p1200 | Thyroid cancer | ECE2018

RET exon 11 genotype in medullary thyroid cancer

Muresan Andrei , Radian Serban , Ghervan Cristina , Gheorghiu Monica , Paun Diana , Baciu Ionela , Ioachim Dumitru , Padure Adriana , Dobrescu Ruxandra , Manda Dana , Badiu Corin

Introduction: RET mutation is a well-known pathogenic event in medullary thyroid cancer. However, less than 25% of MTC cases present a germline mutation. First grade relatives of the patients with germline RET mutations may undergo genetic counselling and prophylactic appropriate therapeutic intervention.Objective: The aim of the study was to evaluate the most frequent pathogenic RET exon 11 mutations and SNP in medullary thyroid cancer (MTC).<p clas...

ea0056p1201 | Thyroid cancer | ECE2018

Serum TSH levels as a predictor of thyroid cancer

Novosad Sophia , Martirosyan Narine

Background: The aim of our study is to show the evaluate relationship between cytological feature of thyroid nodule and TSH level.Objective: To retrospectively evaluate the usefulness of serum TSH levels as a predictor of thyroid cancer.Methods: Patients with thyroid nodule(s) who underwent fine-needle aspiration biopsy under ultrasonographic guidance in a Clinica of Administration of the President of the RF were consecutively eval...

ea0056p1202 | Thyroid cancer | ECE2018

Impact of pregnancy on follow-up of thyroid papillary carcinoma:About 30 cases

Driouich Yasmine , El Aziz Siham , Chadli Asma

Introduction: Thyroid carcinoma is more frequent in women of childbearing age. It can alter both fertility and pregnancy’s course.Objective: The aim of this study was to evaluate pregnancy’s influence on thyroid carcinoma’s prognosis as a factor of recurrence or progression.Patients and Methods: We conducted a descriptive cross-sectional study concerning 30 pregnant patients followed for thyroid papillary carcinoma w...

ea0056p1203 | Thyroid cancer | ECE2018

Comparative study about differences in staging and prognosis in patients affected or not of BRAF V600E mutation

Gonzalez Javier , Calderon Dulce Maria , Alramadan Mubarak , Perez Jose , Martin David , Acedo Raquel , Jimenez Fulgencio , Campos Yolanda

Introduction, material and methods: The BRAF isoform of RAF has been implicated in the pathogenesis of papillary thyroid cancer, but not of benign or follicular neoplasms. Also, BRAF mutations may confer a worse clinical prognosis than for papillary thyroid cancer without the BRAF mutation. Recurrence occurs more frequently when BRAF mutations are present. In addition, BRAF mutations are associated with extrathyroidal invasion, lymph node me...

ea0056p1204 | Thyroid cancer | ECE2018

Synchronous thyroid disease in patients with primary hyperparathyroidism

Bchir Najla , Oueslati Ibtissem , Chihaoui Melika , Yazidi Meriem , Chaker Fatma , Rejeb Ons , Slimane Hedia

Introduction: Retrospective analysis has shown that approximately 17–84% of patients suffering from primary hyperparathyroidism have a concomitant thyroid disease. However, it still remains controversial whether these two pathologies happen coincidental or are caused by specific risk factors or genetic changes. In this study we aimed to evaluate concurrently detected thyroid pathologies in patients who underwent surgery for primary hyperparathyroidism.<p class="abstex...

ea0056p1205 | Thyroid cancer | ECE2018

Association of thyroid papillary carcinomaand an ectopic parathyroid adenoma

Khalil Ikram , El Aziz Siham , Chadli Asmaa

Introduction: Association between primary hyperparathyroidism and nodular thyroid disease is well recognized, this is mainly due to the high prevalence of this disease. However, association between thyroid carcinoma and primary hyperparathyroidism is less common.Observation: Fifty-two years old patient with a history of renal colic and upper limb spontaneous fracture was followed for multinodular goiter evolving for 20 y...