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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

Poster Presentations: Thyroid

Thyroid (non-cancer)

ea0056p1013 | Thyroid (non-cancer) | ECE2018

Assessment of radioiodine treatment for hyperthyroidism

El Feleh Emna , Mahjoubi Sana , Sellem Ali , Ouertani Haroun

Introduction: Hyperthyroidism owing to Graves’ disease or toxic nodular goiter is a common condition seen in clinical practice. The available modes of therapy are antithyroid drugs, surgery and radioiodine (RAI) therapy. Radioiodine is an effective, safe and relatively inexpensive form of therapy in patients suffering from hyperthyroidism. The aim of our study is to assess the effectiveness of radioactive iodine (RAI) treatment in patients with hyperthyroidism.<p clas...

ea0056p1014 | Thyroid (non-cancer) | ECE2018

Dyslipidemia in subclinical hypothyroidism: a case–control study

Qasim Bayar , Arif Sardar , Ahmad Ayad , Abduljabbar Rezvan

Background: Subclinical hypothyroidism (SCH) is a common condition affecting 7.5–8.5% of women and 2.8–4.4% of men. Overt hypothyroidism is characterized by dyslipidemia, however the controversy persists regarding the lipids level in subclinical hypothyroidism (SCH) and its clinical significance. Recent evidence also shows that T4 replacement therapy may improve lipid profile.Aim: The aim of this study is to assess the prevalence of dyslipidemi...

ea0056p1015 | Thyroid (non-cancer) | ECE2018

An eleven–year–old girl presenting with Graves’ ophtalmopathy

Belaid Rym , Jaidane Amel , Oueslati Insaf , Zouaoui Chadia , Ouertani Haroun

Introduction: Graves’ ophthalmopathy (GO) is an autoimmune disorder affecting the retro-orbital tissues. It represents the main extra- thyroidal expression of Graves’ disease (GD). In children, GO is less common and less severe than in adults. Herein we report a case of GO in a child.Case report: An 11-year-old girl with family history of autoimmune thyroid disease was referred to our department for evaluation of suspected hyperthyroidism. She ...

ea0056p1016 | Thyroid (non-cancer) | ECE2018

Choroidal thickness changes in Graves’ ophthalmopathy

Cagiltay Eylem , Akay Fahrettin

Introduction: Graves’ ophthalmopathy (GO) may develop nearly 25–50% in Graves’ Disease (GD). Clinical manifestations of GO are caused by the over compression of orbital tissues within the restricted orbital bone cavity. Impaired ocular blood flow may disrupt the retinal microstructure and functions. Early recognition of retinal and choroidal changes may alert the physicians for preventing ocular complications of GO. In this study we aimed to investigate the macu...

ea0056p1017 | Thyroid (non-cancer) | ECE2018

Post-operative hypocalcaemia following open thyroidectomy for benign multinodular goiters using FOCUS harmonic scalpel versus conventional suture ligation technique for hemostasis – a prospective, single-blind, randomized controlled trial

Zehra Sadaf , Parveen Sughra

Background: Vessel hemostasis during thyroidectomy is the mainstay of reducing the risk of post-operative hypocalcaemia, which can be achieved by using several techniques. The aim of this study was to compare the occurrence of hypocalcaemia 24–48 hours following total thyroidectomy by using FOCUS harmonic scalpel (HS) vs the conventional suture ligation (CSL).Patients and methods: A prospective, single-blind, randomized trial in which 76 patients wi...

ea0056p1018 | Thyroid (non-cancer) | ECE2018

Thyroid disorders and gestational diabetes mellitus: more common than we thought

Imen Sebai , Asma Ben Brahim , Haifa Ben Abdessalem , Insaf Oueslati , Marwa Ben Cheikh , Kamilia Ounaissa , Rim Yahiaoui , Chiraz Amrouche

Aim: Thyroid disorders are very common in women of reproductive age. The aim of this study was to determine the prevalence of different biological thyroid disorders during gestational diabetes mellitus (GDM).Methods: This was a retrospective observational study carried out between March and June 2017 in the day hospital of the National Institute of Nutrition. Pregnant women referred for the management of GDM and who have no history of prior thyroid disor...

ea0056p1019 | Thyroid (non-cancer) | ECE2018

Characteristics and outcome of patients with hyperthyroidism attending a hospital endocrine clinic- a retrospective study

Sim Sing Yang , Lethem Claudia , Coppini David

Aims: A study looking at the incidence, presentation, diagnosis, management strategies and outcomes following anti-thyroid drug treatment and radio-iodine therapy in a cohort of patients presenting with hyperthyroidism.Methods: Retrospective longitudinal study of all patients (n=442) who received treatment for a new diagnosis of hyperthyroidism (Grave’s disease (GD), multinodular goitre (MNG), Toxic nodule) in a secondary care outpatient se...

ea0056p1020 | Thyroid (non-cancer) | ECE2018

How evolve antithyroperoxydase antibody in Hashimoto thyroiditis in time: Study on 450 patients: January 2018

Ratcu Mihaela , Carsote Mara , Ilie Cosmina , Gharibafshar Payman , Staicu Dana Cristina , Peretianu Dan , Oprisan Bogdan

Aim: Most research teams analyze the evolution of patients with Hashimoto thyroiditis (HT) on syndromal basis, not on pathogenetic basis. Thus, most researchers refer to thyroid function evolution. In this study we tried to show how evolve the antithyroid antibodies. Therefore, we analyzed ATPO evolutive patterns.Method: (1) ATPO levels were analyzed in several accreditated Bucharest laboratories. (2) Only patients with minimum 3 investigations were cons...

ea0056p1021 | Thyroid (non-cancer) | ECE2018

Hyperemesis gravidarum mimicking thyroid storm- A diagnostic dilemma in early pregnancy

Lee Yingshan

Introduction: The thyrotrophic effects of human chorionic gonadotrophin (HCG) are responsible for a physiological rise in fT4 and suppression of TSH in early pregnancy. Hyperthyroidism in this period is mostly due to gestational transient thyrotoxicosis (GTT) which is frequently mild and resolves spontaneously by 18 weeks, or due to Graves’ disease (GD) which would require closer monitoring through pregnancy (1). The pathophysiology of hyperemesis gravidarum is unclear, a...

ea0056p1022 | Thyroid (non-cancer) | ECE2018

Correlation between cytologic results and thyroid autoantibodies, calcitonin, and thyroid function tests in patients with thyroid nodules

Karakaya Pinar , Pehlivan Bahar , Mert Meral , Yaprak Bulent , Okuturlar Yildiz , Doganciftci Sema , Akarsu Cevher , Dural Ahmet Cem , Kumbasar Abdulbaki

Aim: Fine needle aspiration biopsy (FNAB) is currently a widely accepted screening procedure in diagnosis of thyroid nodules, there has been confusion related to diagnostic terminology in the assessment of samples. This confusion has been caused by multiple category names, descriptive reports without assigning to a category, and different terminologies used for surgical pathology. We aimed to evaluate correlations between US characteristics, cytologic results of FNAB, and thyr...

ea0056p1023 | Thyroid (non-cancer) | ECE2018

Percutaneous ethanol injection for benign cystic and mixed thyroid nodules

Ozderya Aysenur , Aydin Kadriye , Gokkaya Naile , Temizkan Sule

Background/aim: We aimed to determine the effect of percutaneous ethanol injection (PEI) on volume of cystic and mixt thyroid nodules, thyroid function tests (TFTs), antibody titers and cytological changes for 1 year.Methods: Fifty-five nodules of 53 patients with cystic and mixt properties treated with PEI were included. Nodule volumes, TFTs, thyroid autoantibodies were analyzed at baseline, 6th and 12th months. Fine needle aspirat...

ea0056p1024 | Thyroid (non-cancer) | ECE2018

Post partum and non-post partum relapsing Graves’ hyperthyroidism display different response to anti-thyroid drugs

Capelli Valentina , Rotondi Mario , Coperchini Francesca , Pinto Sara , Croce Laura , Tonacchera Massimo , Chiovato Luca

Background: Graves’ disease (GD) female patients in remission after a full course of methimazole (MMI) therapy are at risk for a relapse of hyperthyroidism during the post-partum (PP) period, but whether this relapse may display any peculiarity is still unknown.Aim: To compare GD patients undergoing a relapse of hyperthyroidism either in the PP period or not.Subjects and methods: Fourty-three female patients of childbearing ag...

ea0056p1025 | Thyroid (non-cancer) | ECE2018

Rare association of primary hyperparathyroidism and toxic multinodular goiter

Elfekih Hamza , Elleuch Mouna , Ghorbel Dorra , Hadjkacem Faten , Ammar Mouna , Kalthoum Mahdi , Charfi Nadia , Abid Mohamed

Introduction: The association of primary hyperparathyroidism (PHPT) and hyperthyroidism secondary to toxic multinodular goiter (TMNG) is rarely described in the literature. Hereby, we describe the clinical, biological, and radiological characteristics of two patients having this rare association.Observations: First case: A 66 years-old female was diagnosed with primary hyperthyroidism. Her thyroid antibodies were negatives. During the follow-up, she pres...

ea0056p1026 | Thyroid (non-cancer) | ECE2018

The thyrotoxicosis in patients with amiodarone induced thyrotoxicosis may not respond totherapeutic plasmapheresis like patients with Graves’ disease

Yildiz Ismail , Elbuken Gulsah , Gurdal Sibel Ozkan , Atasever Tugay , Zuhur Sayid

Introduction: Due to the risk of thyroid storm, achievement of euthyroid state is necessary in patients with thyrotoxicosis undergoing surgery. However, euthyroid state could not be always achieved by antithyroid drugs. Therefore, therapeutic plasmapheresis (TPE) can be used for this purpose.Case 1: A-58-year old male patient was admitted to emergency department with diabetic ketoacidosis (DKA) induced by amiodarone induced thyrotoxicosis (AIT). He had a...

ea0056p1027 | Thyroid (non-cancer) | ECE2018

Effect of metformin therapy on thyroid stimulating hormone and BMI in hypothyroid egyptian patients

Fahmy Eman , Mashahit Mohamed , Mohamed Ghada

Back ground and objectives: Relation between thyroid function with respect to insulin resistance has been a field that is rich and captivating for research and further examination. Few studies have suggested that metformin, the first-line in diabetes management, may lower thyroid-stimu-lating hormone (TSH). Owing to Paucity of studies regarding the effect of metformin on TSH in hypothyroidism patients, this study compares the effect of metformin on TSH and BMI in Egyptian na&#...

ea0056p1028 | Thyroid (non-cancer) | ECE2018

IgM thyroglobulin autoantibodies are detectable in serum of patients with subacute thyroiditis

Brancatella Alessandro , Ricci Debora , Marino Michele , Vitti Paolo , Latrofa Francesco

Context: Subacute thyroiditis (SAT) is an inflammation of the thyroid, likely caused by a viral infection. IgG Autoantibodies (Ab) to the main thyroid antigens, including thyroglobulin (Tg) (TgAb) have been reported in a few patients with SAT and their appearance is usually transient. We investigated whether IgM TgAb can be detected in sera of patients with SAT.Design: Serum samples were collected from 17 patients with SAT, ten with Graves’ disease ...

ea0056p1029 | Thyroid (non-cancer) | ECE2018

Single session treatment of benign thyroid nodules with radiofrecuency ablation: results at 6 months in 17 patients

Familiar Cristina , Merino Salome , Ganado Tomas , Jimenez Ines , Sanabria Concepcion

Introduction: Radiofrecuency ablation (RFA) represents an alternative to surgery for benign thyroid nodules with pressure symptoms or evident progressive growth.Objetives: To analyze in our center the efficacy and safety at 6 montns of a single session treatment of RFA performed in predominantly solid thyroid nodules.Patients and methods: 17 patients with citologically benign thyroid nodules with pressure symptoms (dysphonia, dyspn...

ea0056p1030 | Thyroid (non-cancer) | ECE2018

Fibroblast growth factor 23 is elevated in patients with euthyroid Graves’ disease

Lin Chia-Hung , Shih Shyang-Rong , Tsai Keh-Sung

Background: Graves’ disease (GD) is associated with accelerated bone turnover and elevated fibroblast growth factor 23 (FGF23). FGF23 is involved in the mineral homeostasis, especially the regulation of serum phosphate. Literatures showed that FGF23 decreased along with treatment of GD. It remains unclear whether FGF23 becomes normal after euthyroid status achieved.Methods: A total of 64 patients with euthyroid GD and 64 healthy control subjects wer...

ea0056p1031 | Thyroid (non-cancer) | ECE2018

Evaluation of the iodine sufficiency of pregnant women in Belarus

Petrenko Sergei , Leushev Boris , Mojeiko Vladimir , Mokhort Tatiana , Kolomiets Natalia , Fedorenko Ekaterina , Mokhort Alena

Republic of Belarus belongs to the iodine-sufficient countries. However, the subject of the study is to assess iodine status of pregnant women as the critical group of the population. Iodine deficiency has a negative impact on the level of pregnancy complications and childbirth, increasing the risk of babies with low birth weight, adverse effect on newborn and children of early age health.The purpose of this study: To assess iodine sufficiency of pregnan...

ea0056p1032 | Thyroid (non-cancer) | ECE2018

Thyroid disease in PHPT: a single centre study

Castellano Elena , Gianotti Laura , Latina Adele , Cesario Flora , Baffoni Claudia , Pellegrino Micaela , Tassone Francesco , Magro Giampaolo , Borretta Giorgio

Objective: Primary hyperparathyroidism (PHPT) and thyroid diseases are common in the general population. It is difficult to establish whether they occur in the same patient because of a direct relationship or just due to the widespread prevalence of both conditions. The reported prevalence of the concomitant occurrence of these two clinical conditions is widely scattered (ranging 17–84%), especially due to the heterogeneous criteria for patient selection. We aimed to eval...

ea0056p1033 | Thyroid (non-cancer) | ECE2018

Clinical importance of incidentally discovered thyroid nodule by carotid artery ultrasonography

Young Lee Mi , Hee Cho Eun , Yun Jeong Ji , Min Kim Jung , Seon Shin Mi

Thyroid nodules were frequently incidentally discovered during radiologic studies of chest or neck. We investigated the prevalence and clinical importance of thyroid incidentaloma during carotid artery ultrasonography in patients with diabetes. We retrospectively reviewed the data of enrolling all diabetic patients who were performed carotid artery ultrasonography at the Diabetes Center of Wonju Severance Christian Hospital from January to December 2013. Chart reviews of all e...

ea0056p1034 | Thyroid (non-cancer) | ECE2018

Thyroid function in relation to pregnancy outcome

Mladenovic Violeta , Andjelkovic Marija , Gluvic Zoran , Djukic Aleksandar , Macut Djuro

Introduction: Thyroid disease in pregnancy is a common clinical problem, at least 2–3% of women have thyroid dysfunction, and it is estimated that about 5–20% of women of reproductive age suffer from autoimmune thyroid disease. Subclinical thyroid disease during pregnancy may be associated with adverse outcomes. In the first trimester, the ‘normal’ range for TSH is reduced to 0.1–2.5 mIU/l, and in the second and third trimester is 3.0 mIU/l.<p clas...

ea0056p1035 | Thyroid (non-cancer) | ECE2018

The assessment of vitamin D3 deficiency in patients with Hashimoto’s disease and the relationship between the disease duration and 25OHD3 levels

Lizis-Kolus Katarzyna , Hubalewska-Dydejczyk Alicja , Sowa-Staszczak Anna , Skalniak Anna , Kowalska Aldona , Lizis Pawel

The observed increase in the incidence of Hashimoto’s thyroiditis (HT) requires the research on environmental factors that may initiate or model its course. There have been reports of the impact of vitamin D3 deficiency on HT development.Objective: To assess the degree of deficiency of 25OHD3 and the relationship between the disease duration and 25OHD3 levels in patients with HT.Material and methods: 310 people were enrolled i...

ea0056p1036 | Thyroid (non-cancer) | ECE2018

Hypothyroidism treated with weekly intramuscular thyroxine injections

Kwek Kevin , Teoh Xuyan , Kon Winston

Background: Oral levothyroxine (LT4) is usually an effective treatment for hypothyroidism. However, timing of meals, concurrent medications and gastrointestinal diseases causing malabsorption may impair absorption of oral LT4. We present a patient with Hashimoto’s thyroiditis on LT4 replacement through a gastrostomy tube causing the problem of erratic thyroid function test (TFT) results, successfully managed through the use of once-weekly intramuscular LT4 injection.<...

ea0056p1037 | Thyroid (non-cancer) | ECE2018

Evaluation of thyroid nodule, volume and arterial stiffness in euthyroid individuals

Aydogan Unsal Yasemin , Altay Mustafa , Unsal Oktay , Kaplanoglu Veysel , Cagir Yavuz , Yildiz Canan , Beyan Esin , Uysal Ramadan Selma

Aim: Overt/subclinic hypothyroidism and hyperthyroidism are known to be associated with cardiovascular risks. There have been no studies evaluating the relationship between nodule presence and arterial stiffness in individuals with euthyroid nodular goitre. Our aim in this study is to demonstrate whether nodule presence and nodule stiffness affect arterial stiffness in individuals with euthyroid nodular goitre by using pulse wave analysis (PWA).Materials...

ea0056p1038 | Thyroid (non-cancer) | ECE2018

Iron deficiency, a risk factor for thyroid dysfunction and autoimmunity in the second trimester of pregnancy in China

zhang Yanan , Zha Bingbing

Ferritin is a universal intracellular protein that acts as an iron carrier. Several studies have indicated that iron deficiency affects thyroid function in non-pregnant women. Our objective was to assess the relationship between serum ferritin levels and thyroid function along with thyroid autoimmunity in pregnant women during the second trimester. 1592 pregnant women were recruited from the obstetric outpatient department during the second trimester. Serum ferritin (SF) level...

ea0056p1039 | Thyroid (non-cancer) | ECE2018

A rare case of amyloid goiter with concomitant papillary thyroid microcarcinoma in a patient with HIV

Katkar Rujuta , Lin Thinzar , Makdissi Antoine

Introduction: Amyloid goiter (AG) may be associated with either primary amyloidosis (deposit of amyloid protein AL) or secondary amyloidosis (deposit of amyloid protein AL) in chronic inflammatory diseases including tuberculosis, cystic fibrosis, ulcerative colitis, ankylosing spondylitis and familial Mediterranean fever. To our knowledge, this is the first case of AG concomitant with PTC in a patient with HIV infection.Case presentation: 67-year-old mal...

ea0056p1040 | Thyroid (non-cancer) | ECE2018

A thyroid hormone-independent molecular fingerprint of 3,5-diiodothyronine suggests a strong relation with coffee metabolism in humans

Pietzner Maik , Homuth Georg , Kohrle Josef , Budde Kathrin , Kastenmuller Gabi , Brabant Georg , Volzke Henry , Artati Anna , Adamski Jerzy , Volker Uwe , Nauck Matthias , Friedrich Nele

Background: Numerous animal models have shown impressive beneficial metabolic effects of the putative thyroid hormone (TH)-derivative 3,5-diiodothyronine (3,5-T2), including the prevention of insulin resistance or the reversal of hepatic steatosis, in the absence of thyrotoxic side effects. In contrast, the endogenous fate of 3,5-T2 in humans is still unclear. Comprehensive molecular profiling holds promise to gain deeper insights in metabolic alterations associated with serum...

ea0056p1041 | Thyroid (non-cancer) | ECE2018

The benefits of the thyroid disease screening program in pregnant women in Slovakia

Bielik Matej , Ja B , Kmecova Vladimira , Faktor Marian

Objectives: Screening of thyropathies in Slovakia began in 2009 on the basis of the expert guideline of the Ministry of Health of the Slovak Republic for the diagnosis and treatment of autoimmune thyroid diseases in women during pregnancy (Public Health Ministry 39, 2009, No. 33–39)Methods: The records of pregnant women insured by the health insurance company Dôvera, who had their first documented gynecological visit due to pregnancy in 2011, w...

ea0056p1042 | Thyroid (non-cancer) | ECE2018

Level of awareness in hypothyroid patients

Oncul Nilgun Sesen , Adas Mine

Aims: Hypothyroidism is a common disease and important in terms of community health. To increase the awareness of patients is an important issue in the healthcare process. In this study, it was aimed to determine the level of awareness and the factors affecting the awareness in the patients with hypothyroidism.Methods: A questionnaire was conducted to patients diagnosed with hypothyroidism who were applied to the Okmeydanı Education and Research Hos...

ea0056p1043 | Thyroid (non-cancer) | ECE2018

Predictive value of HLA variants for Graves’ disease recurrence – pilot study in Czech patients

Vejrazkova Daniela , Vcelak Josef , Vaclavikova Eliska , Vankova Marketa , Lukasova Petra , Bendlova Bela

Introduction: Graves’ disease (GD) is the most common cause of hyperthyroidism. The first-choice therapy is administration of thyreostatic drugs. However, approximately half of patients relapse within two years of discontinuation. It is then necessary to decide whether to re-initiate thyreostatic treatment, which may have serious side effects, or to choose a radical approach (TTE, radioiodine). Familial forms of GD indicate that the disease has a significant genetic compo...

ea0056p1044 | Thyroid (non-cancer) | ECE2018

Usefulness of ultrasound evaluation of thyroid nodules in predicting malignancy

Atienza Elena , Trifu Daniela Stefania , Tasende Clara , Escribano Pablo , Saavedra Pilar , Rubio Jose Antonio , Blanco Concepcion

Introduction: Ultrasound (US) thyroid examination is the most common method to assess thyroid nodules risk of malignancy and select nodules for fine-needle aspiration biopsy (FNAB). Thyroid US evaluation performed by endocrinologists has recently increased in Spain.Objectives: To evaluate the predictive value of US features of malignancy in differentiating benign and malignant thyroid lesions in a Thyroid Nodule Clinic.Patients and...

ea0056p1045 | Thyroid (non-cancer) | ECE2018

Ultrasound in stages of surgical treatment of patients with thyroid diseases

Pamputis Sergey , Dyakiv Artem , Aleksandrov Yuri

The results of Surgeon-Performed Ultrasound before and after operations have evaluated at the 207 patients with pathology of the thyroid gland. Comparative assessment made between ultrasound at out-patient phase and Surgeon-Performed by ultrasound. Ultrasound at the outpatient stage in the screening mode does not provide a sufficient level of diagnostics. Causes of errors at this stage are a short time of the inspection, insufficient expertise, wrong interpretation of the imag...

ea0056p1046 | Thyroid (non-cancer) | ECE2018

Active surveillance of indeterminate thyroid nodules beyond cytological diagnosis, ultrasound evaluation and molecular analysis

Santamorena Graziana , Gay Stefano , Mittica Miranda , Monti Eleonora , Massa Barbara , Giusti Massimo

Most thyroid nodules are benign after fine needle aspiration biopsy (FNAB). Nevertheless approximately 10–25% of nodules are classified in indeterminate classes. Literature reports different risks of malignancy in Thy 3 – Thy 4 nodules. In our center malignancy was observed in 26% of Thy 3a nodules and 14% of the Thy 3f nodules (Giusti et al. 2017) while it was >75% in Thy 4 nodules. Strategies for nodules stratification according to risk are now needed ...

ea0056p1047 | Thyroid (non-cancer) | ECE2018

A case of subacute thyroiditis associated with adalimumab

Mehlika Kuskonmaz Serife , Koc Gonul , Ozenmis Tahsin , Ince Muhammed Mustafa , Kirnap Mehmet , Culha Cavit

Subacute thyroiditis is a painful disease of the thyroid gland characterized with granulomatous inflammation. Adalimumab is a human monoclonal anti TNF antibody used in the treatment of several autoimmune diseases. Here we report a case of subacute thyroiditis associated with adalimumab treatment for ankylosing spondylitis. A 42 year old female patient was admitted to the hospital for fever, chills and neck pain radiating to the right ear. She was diagnosed with ankylosing spo...

ea0056p1048 | Thyroid (non-cancer) | ECE2018

Correlation of recommended diagnostic tools with pathological findings in the thyrotoxic patient

Perdomo Carolina M , Paricio Jose Joaquin , Llavero Maria , Gargallo Javier , Garcia Marta , Miralles Raquel , Morales Maria I , Alcalde Juan , Idoate Miguel Angel , Arbizu Javier , Galofre Juan C

Aim: A key diagnostic step to determine the cause of hyperthyroidism is the measurement of circulating thyroid-stimulating immunoglobulin (TSI). High levels are associated with Graves’ disease (GD). A thyroid scintigraphy (TRS) is recommended when TSI is absent or its measurement unavailable, as TRS is capable of differentiating between GD (diffuse uptake) and toxic goitre (TG) (patchy uptake). Nevertheless, and while rarely necessary, histopathology remain the best metho...

ea0056p1049 | Thyroid (non-cancer) | ECE2018

Dependency between vitamin D3 and serum titers of the thyroid autoantibodies in smoking cigarettes patients with Graves’ disease - one year follow-up - preliminary study

Plazinska Maria Teresa , Czarnywojtek Agata , Zgorzalewicz-Stachowiak Malgorzata , Sawicka-Gutaj Nadia , Czarnocka Barbara , Wolinski Kosma , Maciejewski Adam , Komarowska Hanna , Karlinska Maria Maria , Ruchala Marek , Krolicki Leszek

Purpose: The aim of this study was to evaluate the association between the serum vitamin D level and changes in the titers of the anti-TSH receptor (TSHR), antithyroglobulin (Tg), and antiperoxidase (TPO) autoantibodies (Abs) in smoking cigarette Graves’ disease (GD) patients, with and without the vitamin D supplementation.Methods: The study was performed from January 2015 to December 2016. It consisted of 136 patients. The intensity of nicotinism w...

ea0056p1050 | Thyroid (non-cancer) | ECE2018

Visual evoked potentials in the diagnosis of orbitopathy during the course of Graves’ disease

Teresa Plazinska Maria , Zgorzalewicz-Stachowiak Malgorzata , Czarnywojtek Agata , Komar-Rychlicka Krzesislawa , Zenczak-Praga Krystyna , Sawicka-Gutaj Nadia , Czarnocka Barbara , Wolinski Kosma , Ruchala Marek

Graves’ disease (GD) is an autoimmunological disorder leading most often to hyperthyroidism and invasive-edema ophthalmopathy (Graves ophthalmopathy – GO).Aim: Estimation of visual evoked potentials (VEP) results with the indicators of activity and advancement of the progress of GO.Materials and methods: The examined group consisted of 100 patients between the ages of 31 and 77, hospitalized in the Department of Endocrino...

ea0056p1051 | Thyroid (non-cancer) | ECE2018

Thyroid ultrasound alterations occurrence in patients with previous negative examination: A 6-years observational follow-up trial

Monzani Maria Laura , Brigante Giulia , Locaso Michela , Santi Daniele , Graziadei Luigi , Gnarini Valentina Luisa , Simoni Manuela , Madeo Bruno

Background: Thyroid nodules represent a common clinical finding and their prevalence is increasing worldwide. However, the most recent international guidelines do not give indications on the need to retest adults with previous negative neck ultrasound (US).Aim: To evaluate the incidence of thyroid US abnormalities in patients with previous negative thyroid US and identify patient’s characteristics able to predict the risk of developing thyroid disea...

ea0056p1052 | Thyroid (non-cancer) | ECE2018

Evaluation of 32 patients with subacute thyroiditis

Cansu Guven Baris , Taskiran Bengur

Aim: Thyrotoxicosis is a clinical status related to increased thyroid hormones. It is caused by either hyperfunctioning thyroid tissue or destruction of thyroid. Subacute thyroiditis, also known as De Quervain or granulomatous thyroiditis, is an acute inflammatory disease of thyroid causing thyrotoxicosis. Clinical and laboratory features vary according to the course of disease. In this study, we aimed to study clinical and laboratory features of the patients who were referred...

ea0056p1053 | Thyroid (non-cancer) | ECE2018

Cryoablation of goiter irrespective of thyroid profile

Hamed Mohamed , Mansour Sherif , Halawa Mohamed , Bahaaeldin Ahmed , Ibrahim Nesma , Ghoneim Ashraf

Introduction: Thyroid nodules are extremely common. By age 60, about one-half of all people have a thyroid nodule. Cryoablation is used in a variety of clinical applications, using hollow needles (cryoprobes). Cryoprobes are inserted into or placed adjacent to diseased tissue which is desired to be ablated.Objectives: To evaluate the effect of Cryoablation on the size & function of thyroid nodule, which may replace the need for surgery or radiotherap...

ea0056p1054 | Thyroid (non-cancer) | ECE2018

Prevalence and clinico-epidemiology of hypothyroidism in Indian patients with type-2 diabetes mellitus and hypertension

PG Talwalkar , Deshmukh Vaishali , Bhole Milind , Hegde Rashmi

Introduction: Among the most common chronic non-communicable diseases in India, Type-2 Diabetes mellitus (T2DM) and hypertension (HT) are increasingly becoming a matter of public health importance. Hypothyroidism is also believed to be a common health issue in India, with one out of 10 people in the country diagnosed with the condition. Hence the objective of this cross-sectional, clinico-epidemiological, Pan-India study was to evaluate the prevalence of hypothyroidism in pati...

ea0056p1055 | Thyroid (non-cancer) | ECE2018

Pos-thyroidectomy hypoparathyroidism: The role and timing of calcium determination

Baena-Nieto Gloria , Marquez-Pardo Rosa , Diaz-Oteros Mercedes , Garcia-Garcia-Doncel Lourdes

Introduction: Postoperative hypocalcemia is among the most frequent morbidities after total thyroidectomy. Although most postoperative hypocalcemia is temporary, it causes prolonged hospitalization and a decrease in quality of life. For all this, early diagnosis is essential to start treatment as soon as possible. In this study, we determined whether early serum calcium levels can predict the development hipoparathyroidism.Methods: A total of 122 patient...

ea0056p1056 | Thyroid (non-cancer) | ECE2018

Adaptation and cross-cultural validation of the Spanish version of the Thyroid-Related Quality-of-Life Patient-Reported Outcome (ThyPRO) questionnaire

Gonzalez Lleo Ana Maria , Cortes Mauro Boronat , Feldt-Rasmussen Ulla , Perez Carlos Rodriguez , Rasmussen AEse Krogh , Plasencia Yaiza Lopez , Hegedus Laszlo , del Pino Alberiche Ruano Maria , Bonnema Steen Joop , Arencibia Dunia Marrero , Groenvold Mogens , Bjorner Jakob Bue , Watt Torquil

Introduction: The thyroid-related quality-of-life patient-reported outcome ThyPRO questionnaire is the most widely used tool for measuring health-related quality of life (QoL) in patients with benign thyroid diseases. The aim of this study was to adapt and validate a Spanish version of the ThyPRO.Methods: The ThyPRO consists of 85 items, grouped in 13 scales and one single QoL item. Scales cover physical and mental symptoms, well-being and function, soci...

ea0056p1057 | Thyroid (non-cancer) | ECE2018

Antithyroid drugs can be associated with increased frequency of antibodies against type 2 5’-deiodinase enzyme influencing their therapeutical effectiveness in hyperthyroid Graves’ ophthalmopathy

Molnar Ildiko , Szentmiklosi Jozsef A , Gesztelyi Rudolf , Somogyine-Vari Eva

Antithyroid drugs represent mainly the first choice therapy in hyperthyroid Graves’ disease. Their therapeutical ineffectiveness can lead to the onset or the severity of ophthalmopathy associated with Graves’ disease. Type 2 5’-deiodinase enzyme (DIO2) plays a crucial role besides type 1 5’-deiodinase enzyme in the development of Graves’ hyperthyroidism. Anti-thyroid drugs inhibit the activity of both type 5’-deiodinases blocking the synthesis of ...

ea0056p1058 | Thyroid (non-cancer) | ECE2018

The thyroid gland in acromegaly

Dumitriu Roxana , Petrova Eugenia , Buruiana Andra , Ghemigian Adina

Objective: Acromegaly is frequently associated with thyroid diseases. In this study we evaluated the incidence, morphology of the thyroid and the influence of surgery, iradiation and medical therapy used in acromegaly on thyroid function.Methods: We evaluated 20 patients diagnosed with acromegaly using thyroid ultrasonography and measurement of IGF1, GH, TSH, free T4. 65% of the patients had active disease and were under medical therapy.<p class="abs...

ea0056p1059 | Thyroid (non-cancer) | ECE2018

Metabolic profile in patients with subclinical hypothyroidism

Stojkovic Mirjana , Savic Slavica , Ciric Jasmina , Nedeljkovic-Beleslin Biljana , Stojanovic Milos , Zarkovic Milos

Background: Thyroid function regulates a wide array of metabolic parameters and significantly affects lipoprotein metabolism. Subclinical hypothyroidism (SCH) is the most common thyroid disorder, with a prevalence up to 10% in adult populations. Subclinical hypothyroidism is defined as mild elevation in thyroid stimulating hormones (TSH) in presence of normal free thyroxine (fT4) and free triiodothyronine (fT3). This mild elevation of serum TSH is caused by a minor initial dec...

ea0056p1060 | Thyroid (non-cancer) | ECE2018

The efficacy of intrathyroid injected steroids for painful lymphocytic thyroiditis

Paja Miguel , Del Cura Jose L

Thyroidal pain is usually due to subacute thyroiditis. It seldom occurs in patients with Hashimoto’s thyroiditis (HT), and then its name is painful HT (PHT). Differently from subacute thyroiditis, occasional PHT patients show no benefit from medical treatment so that thyroidectomy is frequently needed. We report two women diagnosed of PTH and successfully treated with intrathyroidal corticosteroid injection after initial unsuccessful treatment with L-thyroxine replacement...

ea0056p1061 | Thyroid (non-cancer) | ECE2018

The peripheral blood and thyroid compartment in patients with Graves’ disease: helper and regulatory T-cells and decreased B-lymphocytes

Dudina Margarita , Savchenko Andrey , Dogadin Sergey , Borisov Alexandr , Man'kovsky Vladimir

Graves’ disease (GD) has been recognised for more than 100 years, its pathophysiological mechanisms are incompletely understood.Aim: To investigate the helper- (Th-cells) and regulatory T-cells (Treg) influence on B-lymphocytes phenotypic composition of blood and thyroid tissue in GD.Materials and methods: The study included 43 women with GD, mean age 39.95±14.38, who were performed the epifascial thyroidectomy and 67 hea...

ea0056p1062 | Thyroid (non-cancer) | ECE2018

Influence on remission rates of hyperthyroid periods during anti-thyroid drug therapy of Graves’ disease: retrospective study of N=301 patients

Wojciechowski Natalie , Brix-Samoylenko Harald , Raber Wolfgang

Introduction and aims: Thionamide may have immunosuppressive mechanisms. However, data suggest restoration of the immunological regulation as patients return to the euthyroid state may better explain remission, How successfully patients are kept euthyroid during a course of antithyroid drug therapy for Graves’ hyperthyroidism, and whether not continuously maintaining normal thyroid function is associated with a worse prognosis, is not known.Aims: 1)...

ea0056p1063 | Thyroid (non-cancer) | ECE2018

The accuracy of diagnostic tests in amiodarone-induced thyrotoxicosis; a case-series

Cuesta Martin , Ruiz Cristina Gonzalez , Varas Ines Jimenez , Lapena Luis , Ganado Tomas , Merino Salome , Santiago Alejandro , Recio Lourdes , Pascual Alfonso Luis Calle , Vega Isabelle Runkle de la

Introduction: Amiodarone-induced thyrotoxicosis (AIT) can present a high morbi-mortality.Initial subtype identification facilitates appropriate management.We describe the utility of diagnostic tests in a cohort of patients with AIT.Material and methods: Retrospective, observational study of 59 patients attended from 2007 to 2018 in outpatient clinic. Differential diagnosis: type I if FT4 and FT3 (TH) were normalized following therapy with antithyroid dru...

ea0056p1064 | Thyroid (non-cancer) | ECE2018

Arterial stiffness in hyperthyroid patients is deteriorated due to thyroid hormones

Yildiz Canan , Altay Mustafa , Yildiz Sedat , Cagir Yavuz , Akkan Tolga , Unsal Yasemin Aydogan , Beyan Esin

Aim: It is aimed to evaluate whether arterial stiffness, which is an independent risk indicator for hyperthyroid cardiovascular diseases, is affected by pulse wave analysis (PWA) and to observe changes in patients treated with hyperthyroidism.Methods: A total of 102 volunteers were included in the study (30 in the overt hyperthyroid group, 28 in the subclinical hyperthyroid group and 14 with euthyroidism by antithyroid therapy and 30 healthy). The arteri...

ea0056p1065 | Thyroid (non-cancer) | ECE2018

Gestational and postpartum complications in women with chronic autoimmune thyroiditis receiving iodine and selenium therapy

Szanto Zsuzsanna , Csiszer Attila , Croitorescu Zsuzsanna

Introduction: Iodine may aggravate maternal autoimmune thyroid diseases during and after pregnancy, but selenium could defend against it’s harmful effect. Objective: to study the course and complications of Hashimoto’s thyroiditis in pregnant and lactating women receiving iodine and selenium therapy. Material and method. Serum TSH, free-T4 and anti-thyroid peroxidase-antibody were measured in 30 women with chronic autoimmune thyroiditis in every gestational trimester...

ea0056p1066 | Thyroid (non-cancer) | ECE2018

The effects of exenatide treatment on thyroid

Koseoglu Derya , Baser Ozden Ozdemir , Berker Dilek

Glucagon-like peptide-1 (GLP-1) is an increatin hormon with various glucoregulatory effects, and exenatide is a GLP-1 receptor agonist used in the management of type 2 diabetes mellitus. C cell hypertrophy was seen in animals treated with GLP-1 receptor agonists, but the effects of GLP-1 agonists on C-cell proliferation or neoplasia in humans have not been documented formerly. The aim of this study was to evaluate the impact of exenatide on structural and functional features o...

ea0056p1067 | Thyroid (non-cancer) | ECE2018

Evaluation of anti-thyroglobulin antibodies in pregnant women in Area IV of Asturias

Gonzalez Silvia , Garcia Fernando , Rodriguez Raul , Martin Alicia , Diaz Lucia , Ares Jessica , Menendez Edelmiro

Introduction: Hypothyroidism in pregnancy is a topic widely studied in recent years, especially in those women with positive autoimmunity. However, usually the only determination of antibodies that is made is the thyroid antiperoxidase antibodies (anti-TPO). In this study we wanted to know what incidence of anti-thyroglobulin antibodies (anti-Tg) our pregnant women present and what repercussion they can have on thyroid function.Materials and methods: Ant...

ea0056p1068 | Thyroid (non-cancer) | ECE2018

First extracervical (remote-access) thyroid lobectomy for large specimen without a visible scar via a transoral vestibular and retroauricular approach (TOVARA)

Schopf Stefan , Karakas Elias , Klein Gunther , Schardey Hans Martin

Background: Both Transoral (TOETVA) and several Retroauricular approaches (e.g. EndoCATS) are described as feasible and safe procedures in the literature. The TOETVA enables angulation of instruments and provides a good working space by dividing the strap muscles in the first step. Therefor one should be able to dissect even larger specimen than the short incision in the lip allows to remove. However EndoCATS is a single port access with limited working space, but with good po...

ea0056p1069 | Thyroid (non-cancer) | ECE2018

Study of possible relation between thyroid volume, nodule formation and glucose metabolism disordersin egyptian population

Bahaaeldin Ahmed , El-sherbeny Alyaa , Mohsen Manal , e-lmohsen Emad Abd , Nafie Mahmoud

Insulin resistance (IR) with compensatory hyper-insulinemia are key factors involved in the pathogenesis of glucose metabolism disorders (including impaired fasting glucose and glucose tolerance and frank diabetes mellitus) as well as increased thyroid gland volume and nodule prev-alence in patients with metabolic syndrome. On the other hand, thyroid hormone contributes to the regulation of carbohydrates metabolism and pancreatic function. This cross-sectional study investigat...

ea0056p1070 | Thyroid (non-cancer) | ECE2018

Final diagnosis of thyroid nodules classified as Bethesda-4 after Fine-needle aspiration

Martin Ana Barrera , Alcantara Laguna Maria , Roman Angel Rebollo , Exposito Maria Rosa Alhambra , Moreno Paloma Moreno , Azpilcueta Pedro Segui , Moreno Maria Angeles Galvez

Introduction: Fine-needle aspiration (FNA) is indicated in suspicious thyroid nodules or big ones. Bethesda system classifies them according to the cytological malignancy risk. Bethesda category 4 (B4) comprises follicular neoplasms and suspicious follicular neoplasms. Aim: Determine final diagnosis of B4 nodules and study associations between malignancy and other variables.Methods: Retrospective study of patients with nodules classified as B4 a...

ea0056p1071 | Thyroid (non-cancer) | ECE2018

Thyroid autoantibodies and quality of life in patients with benign thyroid diseases

Mintziori Gesthimani , Veneti Stavroula , Panagiotou Athanasios , Georgiou Thomas , Kita Marina

Objective: Thyroid autoimmunity has been proposed as a risk factor for impaired health-related Quality of Life (HRQoL), depression and anxiety, though evidence is still limited. The aim of the current study is to assess the association of thyroid autoimmunity with quality of life in patients with benign thyroid disease.Design: A cross-sectional study was implemented, that included consecutive patients with benign thyroid diseases who visited the outpatie...

ea0056p1072 | Thyroid (non-cancer) | ECE2018

Iodine deficiency in pregnancy – is the situation in poland improving?

Trofimiuk-Muldner Malgorzata , Sokolowski Grzegorz , Konopka Joanna , Dubiel Agnieszka , Kiec-Klimczak Malgorzata , Kluczynski Lukasz , Motyka Marcin , Rzepka Ewelina , Stefanska Agnieszka , Walczyk Joanna , Wilusz Malgorzata , Lewinski Andrzej , Zygmunt Arkadiusz , Pach Dorota , Hubalewska-Dydejczyk Alicja

Iodine deficiency is considered the most common preventable cause of brain damage worldwide. It is particularly important during pregnancy, as it influences not only mothers but their fetuses as well. The Polish model of iodine prophylaxis is based on obligatory household salt iodization and recommendation of iodine-containing supplements for pregnant women. The aim of the study was to assess the current iodine status of pregnant women and to compare it with earlier results.</...

ea0056p1073 | Thyroid (non-cancer) | ECE2018

Serum thyroglobulin as a biomarker of iodine status in pregnant women

Dolores Ollero M. , Anda Emma , Toni Marta , Pablo Martinez Juan , Espada Mercedes , Javier Pineda J.

Serum thyroglobulin (Tg) is a biomarker used to assess iodine nutrition status, but data in pregnant women are scarce.Objectives: To determine serum Tg concentration in Spanish healthy pregnant women, and to evaluate its relation with yoduria (UIC), thyroid volume, iodine intake and thyroid function throughout pregnancy.Methods: Longitudinal study in pregnant women with no history of thyroid disease, recruited in 2 obstetric center...

ea0056p1074 | Thyroid (non-cancer) | ECE2018

Metabolic signature of hypothyroidism indicating higher cardiovascular risk

Massarini Stefano , Ferrulli Anna , Luzi Livio

Hypothyroidism is associated with higher risk of cardiovascular disease and increase of blood lipids. Previous evidence indicates that high dosage of levothyroxine could be cardiotoxic. There are fewer data describing mortality in subjects after treatment and stabilization of thyroid diseases and there are no data related to subjects with treated hypothyroidism. Aim of this study was to investigate correlations between the cardiovascular risk and metabolic status [Resting Ener...

ea0056p1075 | Thyroid (non-cancer) | ECE2018

Abstract withdrawn....

ea0056p1076 | Thyroid (non-cancer) | ECE2018

Effectiveness of radioiodine treatment for toxic adenoma

Sofia Osorio Ana , Filipa Martins Ana , Vaz de Castro Raquel , Gomes Vania , Faria Carolina , Nobre Ema , Antoine Ferreira Mickael , Cantinho Guilhermina , Joao Bugalho Maria

Objective: The purpose of this study was to assess clinical outcomes of patients with toxic adenoma (TA) treated with Radioactive Iodine (RAIT) in a tertiary hospital over a period of 8 years. We also analysed the influence of age, gender, TSH at diagnosis and anti-thyroid drugs (ATD) previous to RAIT on the cure rate.Methods: Retrospective analysis of clinical records of all patients with TA submitted to RAIT between 2008 and 2015. The influence of demo...

ea0056p1077 | Thyroid (non-cancer) | ECE2018

Effective complex treatment of endocrinous ophthalmopathy (EO) with ophthalmic hyperthyroidism resistent to steroid therapy

Yerdesova Kulshara , Myrzabaeva Aknur

Methods: With the purpose of evaluation of the condition of microlymphocirculation and the efficacy of lymph-stimulating medicines patients are divided into 2 groups: the reference group (p41) - traditional treatment (Thyrozol, Anaprilin). The main group (p16) – traditional treatment + Dalargin (Tyr-D-Ala-Gly-Phe-Leu-Arg, equivalent of leu-enkephalin) 1mg (per 2.0 0.9% NaCl) SC into the lateral part of the eyes No.7. Fluorescent lymphangiography, lymphoscopy, determinatio...

ea0056p1078 | Thyroid (non-cancer) | ECE2018

Diminished levels and defective suppression function of Tr1 cells is observed in patients with autoimmune thyroiditis

Sampedro-Nunez Miguel , Vitales-Noyola Marlen , Serrano-Somavilla Ana , Martinez-Hernandez Rebeca , Aguirre Nerea , Fernandez Elena , Maria Ramos-Levi Ana , Gonzalez-Amaro Roberto , Marazuela Monica

Context: T regulatory type 1 (Tr1) cells are a subpopulation of T lymphocytes (CD4+CD49+LAG-3+IL-10+) lymphocytes that exerts a significant immunosuppressive effect. However, its possible role in autoimmune thyroid disease (AITD) had not been explored so far.Objective: To analyze the levels and function of Tr1 cells in peripheral blood and thyroid tissue of patients with AITD.Design: Cases and controls, observational study.<p c...

ea0056p1079 | Thyroid (non-cancer) | ECE2018

Thyroid amyloidosis mimicking medullary thyroid carcinoma

Faki Sevgul , Aydin Cevdet , Ogmen Berna , Dirikoc Ahmet , Mehmet Inan Haci , Cakir Bekir

Introduction: Amyloid accumulation in the thyroid gland leading to a clinically detectable mass is a rare clinical entity. The diagnosis of thyroid amyloidosis can be confused clinically as well as cytologically with both colloidal goiter or neoplastic processes of the thyroid. We report a case of thyroid amyloidosis that was initially misinterpreted as medullary thyroid carcinoma (MTC) clinical and cytological examination.Case: A 24 years old man with c...

ea0056p1080 | Thyroid (non-cancer) | ECE2018

EMPATHY: a new tool for identifying the most suitable thyroxin formulation in hypothyroid patients

Bellastella Giuseppe , Caputo Mariangela , Ida Maiorino Maria , Longo Miriam , Scappaticcio Lorenzo , Giugliano Dario , Esposito Katherine

Hypothyroidism therapy is based on the administration of appropriate dose of L-thyroxine (L-T4). Absorption of L-T4 takes place in the duodenum and upper tract of the small intestine (jejunum), is maximal when stomach is empty, and is affected by a number of gastrointestinal disorders, including Helicobacter pylori–related gastritis, as well as ingestion of drugs, dietary fibers, and herbal remedies. Failure to achieve a good control of disease may be due to malabsorption...

ea0056p1081 | Thyroid (non-cancer) | ECE2018

Coincidental prolactinoma and parathyroid adenoma in a patient with negative MEN1 and MEN4

Faki Sevgul , Aydin Cevdet , Cuneyt Bilginer Muhammet , Yukselguler Bagdegul , Abbas Tam Ali , Kilic Mehmet , Cakir Bekir

Introduction: Multiple endocrine neoplasia type 1 (MEN 1) is associated with neoplasia and hyperfunction of the parathyroid and pituitary glands, pancreatic islet cells, and neuroendocrine cells of the gut. Many authors advocate routine subtotal or total parathyroidectomy and autotransplantation for these patients. Here we demostrate negative MEN1 and MEN4 gene mutation analysis in a case with prolactinoma and a large parathyroid adenoma that could not be localized with preope...

ea0056p1082 | Thyroid (non-cancer) | ECE2018

How should thyroid-related quality of life be assessed? Standard recall measures compared with here-and-now measures

Boesen Victor Brun , Feldt-Rasmussen Ulla , Bjorner Jakob Bue , Cramon Per , Gronvold Mogens , Nygaard Birte , Rasmussen AEse Krogh , Vilsboll Tina , Watt Torquil

Introduction: Some methodologists have raised concern about the validity of the standard method of assessing patient-reported outcomes, i.e. retrospective questionnaires. Repeated momentary measurements have been introduced to avoid recall bias and provide ecological validity. Although having theoretical advantages, the measurement properties remain unsubstantiated. This study examines the relationship between the retrospective thyroid-related quality of life patient-reported ...

ea0056p1083 | Thyroid (non-cancer) | ECE2018

Radiofrequency ablation of the autonomously functioning benign thyroid nodules: 5-years follow-up

Solovov Viacheslav

Introduction: The aim of this study was to evaluate the safety, efficacy and side effects of radiofrequency (RF) ablation for treating autonomously functioning thyroid nodules (AFTN). The study included the data of single centre.Material and methods: The analysis included the results of the treatment of 127 patients with autonomously functioning benign nodules, received in the Samara Oncology Center in 2012–2015 years. All patients had high level of...

ea0056p1084 | Thyroid (non-cancer) | ECE2018

Clinical and genetic study of autoimmun thyroid disease in a Tunisian multigenerational family

Elleuch Noura , Ghorbel Dorra , Hadjkacem Faten , Elleuch Mouna , Chiboub Marwa , Sessi Salwa , Mnif Mouna , Abid Mohamed

Autoimmune thyroid diseases (AITD), which include Hashimoto thyroiditis (HT), Graves’ disease (GD) and primary idiopathicmyxoedema (PIM), are recognized by their clinical and genetic heterogeneity. In this study, we have carried on a global approach gathering 20 year genetic and clinical data on a Tunisian multigenerational family (Akr). Our purpose was search for a combined genotype involved in AITD susceptibility using 33 gene polymorphisms. The Akr pedigree is composed...

ea0056p1085 | Thyroid (non-cancer) | ECE2018

High endocan level is associated with Graves’ disease

Aksan Sami , Yalcin Mehmet Muhittin , Altinova Alev Eroglu , Akturk Mujde , Toruner Fusun Balos

Endocan has been suggested as a marker for endothelial dysfunction. Some evidence exists that Graves’ disease may be associated with impaired endothelial function. The aim of the study was to evaluate serum endocan, endothelial growth factor (VEGF) and carotid intima media thickness (CIMT) in patients with Graves’ disease. Thirty one newly diagnosed patients with Graves’ disease and 31 healthy volunteers with similar age and sex were examined. Serum endocan, VEG...

ea0056p1086 | Thyroid (non-cancer) | ECE2018

Segregation of S292F TPO gene mutation in three large Tunisian families with thyroid dyshormonogenesis: evidenceof a founder effect

Ghorbel Dorra , Hadjkacem Faten , Mnif Fatma , Loukil Fatma , Mnif Mouna , Elleuch Noura , Abid Mohamed

We aimed to identify causal mutation(s) in 13 patients with thyroid dyshormonogenesis (TD) from three consanguineous Tunisian families. A 12-year clinical follow-up showed phenotypic variability ranging from the presence to the absence of goiter, sensorineural deafness, and mental retardation. Genetic analysis using microsatellite markers within two candidate genes (TPO and PDS) gave evidence of linkage with the TPO gene. Sequencing of its 17 exons and their flanking intron-ex...

ea0056p1087 | Thyroid (non-cancer) | ECE2018

When thyroid pathology becomes an emergency: about four cases

Bahia Habra , Ghizlane Elmghari , Nawal El Ansari

Introduction: The thyroid emergency is a rare and life-threatening condition. These are severe complications of benign thyroid disease.Patients and method: We report cases of thyroid pathology constituting an emergency and have been collected over 2 years in the department of endocrinology of the CHU Mohammed VI of Marrakech.Results: Four cases of thyroid emergency were reported: three cases of acute thyrotoxic cri...

ea0056p1088 | Thyroid (non-cancer) | ECE2018

Dysthyroidism and chromosomal aberrations

Ghorbel Dorra , Mnif Fatma , Chebbi Donia , Salah Dhouha Ben , Rekik Nabila , Abid Mohamed

Introduction: Dysthyroidism is not uncommon during chromosomal aberrations. The objective of this work is to study the characteristics of this association at the epidemiological and clinical levels.Methods: This is a retrospective study of 27 cases of patients with trisomy 21 chromosomal abnormalities (6 cases), klinefelter syndrome (4 cases) and Turner syndrome (17 cases) genetically confirmed, collected at endocrinology service at Sfax University Hospi...

ea0056p1089 | Thyroid (non-cancer) | ECE2018

Riedel’s Thyroiditis with Hypothyroidism and Hypoparathyroidism

Taskaldiran Isilay , Firat Sevde Nur , Koc Gonul , Demirturk Pelin , Culha Cavit , Erdogan Murat Faik

Riedel thyroiditis (RT) is a rarest form of thyroiditis, and characterized by dense fibrosis of the throid gland and infiltration into surrounding tissues. RT generally presents with local symptoms association with compression and also fibrotic process can impact thyroid and parathyroid functions. We report a case with RT which presents with compression findings and also hypoparathyroidism and hypothyroidism. 30 year old women visited our outpatient clinic with a complaint of ...

ea0056p1090 | Thyroid (non-cancer) | ECE2018

Our experience in the first year of radiofrequency ablation of benign thyroid nodules

Escobedo Raul Rodriguez , Martinez Silvia Gonzalez , Urruzola Fernando Garcia , Iglesias Soraya Lanes , Nieto Alicia Martin , Naya Lucia Diaz , Blanco Jessica Ares , Garcia Bonel Arguelles , Garcia Ana Maria Montes , Ragnarsson Cecilia Sanchez , Torre Edelmiro Luis Menendez

Purpose: At the beginning of 2016, radiofrequency ablation of benign thyroid nodules began to be carried out at the Central University Hospital of Asturias (Spain). The aim of this study was to evaluate the results obtained by the moment with the aforementioned technique.Methods: It is a descriptive study carried out through the data obtained during the process and the subsequent analytical and ultrasonographic follow-up. In addition, patient surveys hav...

ea0056p1091 | Thyroid (non-cancer) | ECE2018

Utility of 99 Tc-MIBI scintigraphy for the assessment of thyroid nodules with bethesda III cytologies

Perez Marta Sanchez , Rey Lola Santos , Tome Ana Gloria Villas , Castro Ma Jesus Diez , Coll Teresa Canela , Garcia Marta Hernandez , Mellah Chadia Mizab , Carrasquilla Liliana Patricia Gutierrez , Riu Ferran Rius

Introduction: Up to 30% of the thyroid nodules studied with fine needle aspiration biopsy (FNAB) are reported as Bethesda III, a category that does not rule out malignancy. One technique that could help to decide if there is a surgical indication is (99 m) Tc-sestaMIBI scintigraphy (MIBI).Material and methods: All patients with a Bethesda III result were prospectively included, and 99 Tc-MIBI scintigraphy was performed prior to surgery. All exams, includ...

ea0056p1092 | Thyroid (non-cancer) | ECE2018

Shopping trip and a thyroid storm

Kumar Ankit , Sakthibalan Sreekanth , Bonner Caoimhe , Grant Bonnie , Hussain Shazia , Hawkins Anna , Casey Edel , Nikookam Khash

A previously fit and well 27 year old Ghanaian male was brought to hospital by his cousin due to new behavioural changes. The patient was described by his cousin as a normally reserved, self-sufficient man who had become a polar opposite ‘irritable’ personality that ‘spent extravagantly’. He repeatedly claimed to be ‘God’s protection’ and responded aggressively to visual hallucinations. This had resulted in social exclusion and loss of employ...

ea0056p1093 | Thyroid (non-cancer) | ECE2018

Should tocilizumab be a second-line treatment of active, moderate-to-severe Graves’ Orbitopathy?

Caceres Rocio , Herrero Ana , Recio-Cordova Jose Maria , Sanchez-Marcos Ana , Higueruela Cecilia , Beaulieu Myriam , Iglesias Rosana , Robles Cristina , Garcia-Duque Maria , Corrales-Hernandez Juan Jose

Introduction: Graves’ orbitopathy (GO) is the most common extrathyroidal manifestation of Graves’ disease. The first-line treatment are intravenous corticoids in active moderate-severe GO. Tocilizumab is a humanized monoclonal antibody against the IL-6 receptor which has been approved for the treatment of rheumatoid arthritis and is in its research stage for patients with corticosteroid-refractory GO.Objectives: To assess the experience with to...

ea0056p1094 | Thyroid (non-cancer) | ECE2018

Features and determinants of hypothyroidism in patients with major beta thalassemia from Algeria.

Belazzouz Abderahman Youssouf , Azzouz Malha , Khouja Ziane , Nacer Ahmed , Boudiba Aissa , Yargui Ilyes

Introduction: Hypothyroidism is the most common endocrine pathology during Major Beta Thalassemia (MBT). The geographic area is considered a factor in establishing the prevalence and form of hypothyroidism in MBT. We have tried through this study to establish features and determinants of hypothyroidism in Algeria.Patients and methods: Twenty patients middle-aged 27 years (20–46 years) (10 males/10 Females) hospitalized in Pierre Marie Curie Center, ...

ea0056p1095 | Thyroid (non-cancer) | ECE2018

Serum chemerin and other dyslipidemia markers in patients with autoimmune thyroiditis

Berta Eszter , Harangi Mariann , Varga Viktoria E , Lorincz Hajnalka , Seres Ildiko , Halmi Sandor , Nagy Endre V , Paragh Gyorgy , Bodor Miklos

Aim: Chemerin, a recently discovered adipokine produced by the adipose tissue and liver, along with other atherosclerosis markers, was associated lately with metabolic syndrome and acts as chemoattractant for immune cells may also regulate immune cell properties. Autoimmune Hashimoto’s thyroiditis even with sTSH levels corrected to be within the normal range values may be accompanied by dyslipidemia presenting increased total-C, TG, LDL-C, and Lp(a), all of which are pote...

ea0056p1096 | Thyroid (non-cancer) | ECE2018

Current iodine status in a Romanian school-aged children

Nuta Daniela , Nanu Michaela Nanu , Moldovanu Florentina , Nanu Ioana , Ardeleanu Ioana Sonia

Introduction: Iodine deficiency is one of the most important cause of mental and physical disorders and is considered a public health issue. Previous studies reported the existence of iodine deficiency in several regions in Romania and its related negative side effects on children’s health. Therefore, Romania has implemented the universal salt iodisation (USI) since 2002.Aim: The present study aimed to assess the current iodine status in Romanian sc...

ea0056p1097 | Thyroid (non-cancer) | ECE2018

Primary thyroidal paraganglioma in a 60 years old female with thyroid goiter

Sapounas Spyridon , Manthakos Christos , Pissia Maria , Saltiki Katerina , Anastasiou Eleni , Zapanti Evangelia

Primary Paraganglioma of Thyroid Gland is an extremely rare neuroendocrine tumor. Less than 50 cases have been reported up to date and its rarity is the reason why it’s often mistaken for thyroid nodule or other thyroid neoplasms. In this case we describe the misleading results of ultrasonography followed by FNA-biopsy, which led to a total delay of two years until final diagnosis. A 60 year old female presented with a 38 mm right-sided thyroid module. An ultrasound guide...

ea0056p1098 | Thyroid (non-cancer) | ECE2018

Management particularities of substernal goiter

Chiraz Halwani , Imene Zoghlami , Cyrine Zgolli , Khmaies Akkari , Rania Ben Mhamed

Introduction: The definition of a substernal goiter is not univocal, several definitions have been advanced. It poses difficulties by its therapeutic features and management. The aim of this presentation was to detail the particularities of the management of substernal goiters and their therapeutic difficulties.Methods: This is a retrospective study carried out on 40 patients with substernal goiter admitted to our department and treated during a period o...

ea0056p1099 | Thyroid (non-cancer) | ECE2018

A case of respiratory arrest associated with sepsis induced myxoedema coma

Nogueira Edson , Khin Kyaw , Hope David , Idowu Oluwagbemiga , Sathianathan Vivian , Darko Daniel , Rahman Mushtaqur

A 58-year old previously independent man with background of poorly-controlled hypothyroidism, T2DM, hypertension, ischaemic cardiomyopathy, and CKD presented to hospital feeling generally unwell, with a dry cough. His regular medications included anti-hypertensives, L-thyroxine 50 μg daily, linagliptin, insulin, aspirin, atorvastatin, and thiamine. On admission, the TSH was 83 mIU/l, free T4 6.5 pmol/l and free T3 was 1.9 pmol/l; four months earlier, the TS...

ea0056p1100 | Thyroid (non-cancer) | ECE2018

Prevalence of thyroid dysfunction in Catalonia from two different registers: pharmaceutical delivery records and diagnostic records (EUthyroid project)

Torrejon Sara , Soldevila Berta , Martin-Baranera Montse , Puig-Domingo Manel , Velasco Ines , Vila Lluis , Thyroid Area of Spanish Society of Endocrinology and Nutrition

Background: Cross-sectional studies performed to estimate the prevalence (Prev) of thyroid dysfunctions are expensive and involve a great effort. Diagnosis and therapeutic prescription records may be a good alternative to monitor such prevalence. They also allow to easily compare the thyroid dysfunctions prevalence of among different populations (EUthyroid Project).Objective: 1) To estimate the Prev of hypothyroidism (hypoT) and hyperthyroidism (hyperT) ...

ea0056p1101 | Thyroid (non-cancer) | ECE2018

Dysthyroid optic neuropathy in Grave’s disease: two case reports

Marques Julia Vieira Oberger , Lagana Caio Cesar Cervi , Junior Neudir Frare , Amaral Patricia Oliboni Do , Robl Marcela , Besen Debora Cristina , Junior Cleo Mesa , Amaral Gisah Do , Graf Hans

Introduction: Ophthalmopathy is the most common extrathyroidal manifestation of Grave’s disease, with 3–7% evolving to Dysthyroid Optic Neuropathy (DON), which requires urgent treatment to avoid permanent or progressive visual loss. We describe two cases of DON evaluated at Endocrinology and Metabolism Service of Paraná (SEMPR).Case 1: Male, 70 years old, previously diagnosed with hypertension, type 2 diabetes with insulin use, microvascul...

ea0056p1102 | Thyroid (non-cancer) | ECE2018

Conversion from thyroxine-treated autoimmune hypothyroidism to Graves’ disease

Gheorghiu Monica Livia , Burciulescu Sofia Maria Lider , Purice Mariana , Alexiu Florin

Graves’ disease (GD) and Hashimoto’s thyroiditis (HT) are both autoimmune thyroid diseases. While transition from GD to hypothyroidism has been more frequently reported, conversion of hypothyroidism to GD is uncommon. We describe a series of 3 patients diagnosed with HT and hypothyroidism, treated with L-thyroxine (LT4), who developed persistent hyperthyroidism with increased thyrotropin receptor antibodies (TRAb) levels and, in two of the patients, Graves’ opht...

ea0056p1103 | Thyroid (non-cancer) | ECE2018

Cholestyramine: a useful therapeutic adjunct in severe thyrotoxicosis

Kumar Mohit

Case 1: A 32 year old fit and well female presented with symptoms of thyrotoxicosis and goitre. Her initial investigations revealed fT4 45 pmol/l (10–20) and fT3 26 pmol/l (3.5–6.5), with undetectable TSH. TSH receptor antibodies were positive. She was commenced on beta blockers and carbimazole and increased to 60 mg daily, with the fT4 improving only to 34.4 and fT3 to 13.8. Cholestyramine was commenced and titrated to a dose of 4 g twice daily, with resultant norma...

ea0056p1104 | Thyroid (non-cancer) | ECE2018

Elevated level of serum calcitonin of unknown origin

Cepkova Jitka

We describe a case of a 59-years old man, in whom a thyroid nodule with a size of 16 mm and an elevated serum calcitonin level 29 ng/l (upper limit 21 ng/l) was incidentally found. The size of a nodule did not increase in time, serum level of calcitonin was stable and cytology from the nodule was benign. In January 2016, calcium stimulation test was performed with a positive result (baseline calcitonin 31.5 ng/l, stimulated calcitonin 417 ng/l), CEA was low. The patient was re...

ea0056p1105 | Thyroid (non-cancer) | ECE2018

Prevalence of thyroid nodules in thyrotoxicosis detected in pregnancy

Irigaray Ana , Ollero Maria Dolores , Iriarte Ana , Terreros Amaya Sainz de los , Munarriz Patricia , Eguilaz Nerea , Ernaga Ander , Zubiria Juan

Introduction: The aim of our study was to evaluate the causes of thyrotoxicosis detected during pregnancy as well as to determine the prevalence of thyroid nodular disease (TND) in our population and which factors are associated with this condition.Methods: We performed a retrospective review of 1,760 patients between April 2014 and September 2017 remitted from the gynecology department due to thyroid dysfunction detected in the 9th week of pr...

ea0056p1106 | Thyroid (non-cancer) | ECE2018

Analysis of association of vitamin D receptor gene Cdx2 (rs11568820) polymorphism with autoimmune thyroid diseases

Maciejewski Adam , Kowalczyk Michal J , Gasinska Teresa , Herman Waldemar , Szeliga Anna , Dorszewska Jolanta , Zaba Ryszard , Lecka Katarzyna

Introduction: Vitamin D is postulated to play a significant role in the immune system modulation and its deficiency has been reported in some autoimmune disorders. Polymorphisms of different vitamin D-related genes, among them vitamin D receptor gene (VDR), could either be a risk factor for autoimmune diseases. Therefore the aim of the study was to assess the association between VDR Cdx2 (rs11568820) polymorphism and autoimmune thyroid disease (AITD) among th...

ea0056p1107 | Thyroid (non-cancer) | ECE2018

A case of severe hypothyroidism, correcting to euthyroidism through Graves’ disease associated with refractory thyroid eye disease

Nasser Ali Al , Chammas Nida , Maalouf Natalie

A 54-year-old female presented to the neurologist in December 2017 with neuromuscular right arm weakness, lethargy and fascial swelling. She had a normal MRI head before being referred to the endocrine clinic with a TSH >125 mIU/l (0.27–4.2 mIU/l). Free T4 was 0.3 pmol/l (12.0–22.0) with a free T3 of <0.4 pmol/l (3.1–6.8). The thyroglobulin antibody was 1366 IU/ml (0–115) with a normal thyroid peroxidase level (TPO) 29.7 (0–34). No previous thy...

ea0056p1108 | Thyroid (non-cancer) | ECE2018

Changes of visfatin/NAMPT serum concentration and its leukocyte expression in hyperthyroidism

Sawicka-Gutaj Nadia , Zybek-Kocik Ariadna , Kloska Michal , Czarnywojtek Agata , Sowinski Jerzy , Budny Bartlomiej , Wolinski Kosma , Ziemnicka Katarzyna , Mankowska-Wierzbicka Dorota , Ruchala Marek

Purpose: The aim of the study was to investigate changes of visfatin/NAMPT serum concentration and its leukocyte expression in hyperthyroid patients.Material and methods: The study was designed as a single-center, cross-sectional with consecutive enrollment. We included all patients with newly diagnosed overt hyperthyroidism (Graves’ disease or toxic nodular goiter). Each subject underwent physical examination, laboratory investigation, body composi...

ea0056p1109 | Thyroid (non-cancer) | ECE2018

Congenital hypothyroidism: genes involved in organogenesis disorders

Chaabane Rim , Gargouri Imen , Hadjkacem Faten , Mrabet Houssem , Elleuch Mouna , ghorbel Dorra , Mnif Mouna , Charfi Nadia , Belguith Neila , Abid Mohamed

Introduction: Congenital hypothyroidism (CH) is the most common congenital endocrine disease since it affects 1/3000–1/4000 births. The involvement of genetics is no longer discussed and several genes have been implied in the different clinical forms of thyroid dysgenesis.Patients and methods: We report ten cases of thyroid dysgenesis collected at the pediatric and endocrinology departments of Sfax in Tunisia. The diagnosis was based on clinical, bi...

ea0056p1110 | Thyroid (non-cancer) | ECE2018

Abstract withdrawn....

ea0056p1111 | Thyroid (non-cancer) | ECE2018

Intrathyroidal cyst with squamous metaplasia

Brdar Dubravka , Soso Gordana , Baric Ana , Sladic Sanda , Majstorovic Tina , Punda Ante

The occurence of multiple squamous cells in thyroid fine needle aspirate is rare.Aim: We report a case of multiple squamous cells in thyroid aspiration specimen in a patient with chronic lymphocytic thyroiditis.Case report: A 56-year-old woman has been observed for several years because of chronic lymphocytic thyroiditis and hypothyroidism. She was on levothyroxine supstitution therapy. Six years ago ultrasonography revealed inhomo...

ea0056p1112 | Thyroid (non-cancer) | ECE2018

Levothyroxine absorption test: a safe help for difficult cases

Lopes Ana , Teresa Pereira Maria , Lito Pedro , Freitas Claudia , Teixeira Sofia , Cardoso Helena

Levothyroxine (L-T4) is the mainstay of treatment of hypothyroidism. Marked elevation of thyrotropin (TSH) in patients on high replacement doses is rare and can result from malabsorption, drug interaction or poor compliance. The levothyroxine absorption test is required to distinguish these causes and has proved to be safe. This test measures the serum free thyroxine (FT4) response to 1 mg of oral L-T4 over 4–24 h.Clinical cases: Case no 1: A 28-yea...

ea0056p1113 | Thyroid (non-cancer) | ECE2018

Pasireotide and Graves’ orbitopathy: outcome in terms of efficacy compared to parenteral metilprednisolone; a pilot study

Le Moli Rosario , Castoro Carlotta , Mouritz Maarten , Souters Maarten

Objective: Graves’ orbitopathy (GO) is an autoimmune disease that affects about 25% of the patients with Graves’ disease. The thyrotropin receptor (TSHR) is the main autoantigen of GO. Somatostatin receptors (SSR) are expressed by orbital fibroblasts (OB) of GO patients. Pasireotide (SOM230) is a somatostatin analog that has a great affinity for the type 1 and type 5 SSRs and inhibits both orbital human lymphocyte and OB proliferation in vitro. Therefore it is intere...

ea0056p1114 | Thyroid (non-cancer) | ECE2018

Prediabetes and cardiovascular risk factors in patients with autoimmune thyroiditis

Neves Celestino , Castro Oliveira Sofia , Sergio Neves Joao , Sokhatska Oksana , Pereira Miguel , Oliveira Ana , Luis Medina Jose , Delgado Luis , Carvalho Davide

Introduction: Thyroid hormones modulate the insulin sensitivity and glucose metabolism. The interrelation between thyroid autoimmunity, thyroid function, glucose metabolism and cardiovascular risk factors remains uncertain.Methods: We recorded thyroid function tests, BMI, IR markers comprising the Homeostasis Model Assessment for insulin resistance (HOMA-IR and HOMA-B), the Quantitative Insulin Sensitivity Check Index (QUICKI), HISI (Hepatic Insulin Sens...

ea0056p1115 | Thyroid (non-cancer) | ECE2018

The significance of rare genetic variants in the thyroid autoimmunity – brief review and our own results on SLC26A4 variants in Hashimoto’s thyroiditis

Jabrocka-Hybel Agata , Skalniak Anna , Pietkowski Jakub , Hubalewska-Dydejczyk Alicja

Identified genetic players for most common diseases are not sufficient to explain their heritability. This situation is known as the missing heritability problem. One among the possible explanations is the impact of rare variants. We present our own results of rare variants in the gene SLC26A4 in Hashimoto’s thyroiditis (HT), which were not found in controls, and therefore confirm the possibility of their impact on this disease. We genotyped 147 Hashimoto’s ...

ea0056p1116 | Thyroid (non-cancer) | ECE2018

High dose metformin in obese PCOS patients with subclinical hypothyroidism

Emil Ranetti Aurelian , Pati Cucu Anca

Background: Polycystic ovarian syndrome (PCOS) diagnosis is set based on Rotterdam criteria, including hyperandrogenism, chronic anovulation and typical ultrasound appearance. 65–70% of women with PCOS have insulin resistance. Metformin, an oral antidiabetic agent, was the first drug used to treat insulin resistance in PCOS patients.Material and method: Twenty non-diabetic women between 25–35 years old, with PCOS untreated prior to presentation...

ea0056p1117 | Thyroid (non-cancer) | ECE2018

Selenium supplementation and progression of Graves orbitopathy

Velija Asimi Zelija , Burekovic Azra , Dizdarevic-Bostandzic Amela , Godinjak Amina , Tuco Amela

Selenium (Se) is a micronutrient of vital importance to human health. It acts as an antioxidant, immunomodulator and also it is involved in the control of specific endocrine pathways. In adults, the thyroid is the organ with the highest amount of selenium per gram of tissue. The literature suggests that selenium supplementation of patients with Hashimotos thyroiditis is associated with a reduction in antithyroperoxidase antibody levels. Selenium supplementation also in mild Gr...