Endocrine Abstracts

Objective: The aim of this study is to evaluate clinical characteristics of patients diagnosed of follicular thyroid carcinoma and to study factors that are associated with a worse prognosis of the disease.

Methods: We included 153 patients diagnosed of follicular thyroid carcinoma in our centre between January 1985 and December 2016. The baseline characteristics of the patients, and their long-term outcomes were collected. The mean follow-up was 15.2 years.

Results: The mean age of the patients was 45.6±15.2 years and we found a higher prevalence of women (79.1%, n=121). The mean tumor size was 36.3±17.8 mm. According to the AJCC/TNM classification, we observed 94 patients (61.4%) in stage I, 36 patients (23.5%) in stage II, 18 patients (11.8%) in stage III and three patients (2%) in stage IV. There was a higher prevalence of minimally invasive tumors (84.3% vs. 15.7%). In the follow-up, 3.9% of the patients died due to the tumor or had recurrence or persistence of the disease at the end of the study. In the univariate analysis the presence of persistence/recurrence or death was associated with an increased age, TNM classification at diagnosis and histological subtype (minimally or widely invasive). Using a multivariate model (logistic regression) only the histological subtype was associated with a worse tumor prognosis (P=0.041).

Conclusion: - In our study, the 10 years disease-free survival rate of patients diagnosed of follicular thyroid carcinoma was 96.4%.

- The most important predictor of persistence/recurrence of the disease or mortality was the histological subtype.

- The 10 years disease-free survival of widely invasive tumor was 80.2%