Endocrine Abstracts

The objective of the study was to evaluate the prevalence of secreting profile among a series of subjects with incidental discovered adrenal tumors. Subjects. 139 subjects (112 women and 27 men) diagnosed with adrenal tumors between 2010 and 2015 in our department.

Methods: Medical records were retrospectively analysed for demographic data, routine tests, specific adrenal hormones measurements, associated diseases.

Results: Regarding the tumor localisation, 46.5% of the subjects had left adrenal tumors, 31.5% on the right adrenal gland and the other had bilateral tumors. Forty out of all subjects (28%) had a positive test for an adrenal hormonal secretion according to diagnosis tests criteria for either cortisol, cathecolamines or aldosterone: 87% for cortisol, 8% for cathecolamines and 5% for aldosterone. Measurements of the adrenal hormones were not done routinely in all subjects, presence of high blood pressure in a young patient beeing a selection criteria in the majority of the cases. On the other hand cortisol secretion evaluation was the most affordable and accesible measurement in the studied clinical setting; thus it was done in all the subjects. Cathecolamines and aldosterone secretion was evaluated in less than 20% of the subjects.The secretory characteristic of the tumors was significantly correlated to bilateral tumors (85% vs 68% on right or 47% on the left). A significantly increased diameter of the tumor (2.7 cm) was found in secretory ones vs non secretory (2.2 cm, P<0.05) No significant correlations were found between positive hormonal secretion of the tumors and gender, localisation, BMI, age, associated diseases. Conlcusion. Twentyeight percent of the patients with and incidental discovered adrenal tumor had a positive secretory profile wich was associated to a greater diameter of the tumor and bilateral localisation. The most frecvent found secretion was cortisol, finding which is most probable biased by a more available measurement.