ECE2018 Poster Presentations: Diabetes, Obesity and Metabolism Cardiovascular Endocrinology and Lipid Metabolism (25 abstracts)
Specificity of mathematical indexes versus histopathological findings in the diagnosis of nonalcoholic fatty liver disease in mexican population
Mónica del Carmen Preciado-Puga 1 , Juana-Rosalba García-Ramírez 2 , Lorena del Rocío Ibarra-Reynoso 1 , Karen-Ivette Gutiérrez-Aguirre 1 , Marion Velázquez-Villafaña 1 , Maria-Luisa Lazo-de-la-Vega-Monroy 1 , Yeniley Ruiz-Noa 1 , Benjamín Jordán-Pérez 2 & Serafin Garnelo-Cabañas 2
1Universidad de Guanajuato, Campus León, Mexico; 2Hospital General León, León,Gto, Mexico.
Introduction: Non-alcoholic fatty liver disease (NAFLD) is an emerging disease in Mexico and it could become in a public health problem, this one understands a spectrum of histopathological findings ranging from simple steatosis to steatohepatitis and cirrhosis. The gold standard continues to be the liver biopsy, but several mathematical indexes have been proposed, such as non-invasive techniques, however there are very few studies in our population. This study aims to compare the specificity of mathematical indexes and histopathological findings for the detection of NAFLD in Mexican population.
Methods: A cross-sectional study was performed at the ‘Hospital General Regional de León’. Patients aged 18 years or above that underwent laparoscopic cholecystectomy were recruited. No history of alcohol consumption habit or hepatic diseases characterized the patients. The fatty liver index (FLI) and the lipid accumulation product (LAP) were calculated. Demographics, blood samples, and a liver biopsy were obtained. Results between FLI, LAP and livery biopsy were compared. The area under de curve (AUC) was calculated for each mathematical index SPSS V21 was used for statistics analysis.
Results: A total of 152 patients were included (84.9% women and 15.1% men). The mean age was 38.7±12 years, BMI 28.8±5.3 kg/m2. The FLI identified 80 patients with NAFLD of whom 60% were corroborated with biopsy, whereas the LAP identified 87 patients of whom 55.2% were corroborated with biopsy. From the patients with FLI negative index (n=72), a total of 26% has a histopathological diagnosis of steatosis. For LAP, 65 patients were negative, of which 29.2% presented positive biopsy for the presence of NAFLD. The AUC for FLI was 0.69 whereas the AUC for was LAP 0.68 using ROC curve.
Conclusion: According to our results, the efficiency of these two mathematical indexes are regular for the diagnosis of NAFLD due their specificity at least our population, so liver biopsy remains to be the gold standard for the detection of NAFLD in our population. Future studies should be performed in order to continue looking for other non-invasive markers for NAFLD.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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