ECE2018 Poster Presentations: Diabetes, Obesity and Metabolism Diabetes (to include epidemiology, pathophysiology) (73 abstracts)
Study of the association of transcription factor 7 like 2 gene polymorphism with type 2 diabetes mellitus and diabetic nephropathy in the Egyptian population
Alshaimaa Rezk Alnaggar 1 , Randa Fayez Abd El-salam 1 , Normeen Hany Rady 2 , Marianne Fathy Ishak 2 & Soha Hamed Ammar 2
1Internal Medicine department, Cairo University, Cairo, Egypt; 2Clinical Pathology, Cairo University, Cairo, Egypt.
Background: Studies from different parts of the world have given controversial results regarding the association of transcription factor 7like 2 (TCF7L2) gene polymorphism with Type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN). Aim: This study aimed to investigate if TCF7L2 gene polymorphism, rs12255372(G>T) is a risk factor for the development of T2DM and DN in type 2 Egyptian diabetic patients. PATIENTS AND METHODS: This study was conducted on 150 subjects, divided into three groups (50 type-2 diabetic patients without nephropathy, 50 type-2 diabetic patients with nephropathy (DN) and 50 age and sex matched normal subjects). Genotyping for the rs 12255372(G>T) polymorphism in TCF7L2 gene was performed by real time PCR. RESULTS: There was statistically significant association between TCF7L2 gene polymorphism rs 12255372 and type 2 diabetic patients & DN, P=0.005, the allelic frequency differed significantly between the three studied groups P=0.005, denoting that the G allele was the risky allele for developing T2DM & DN. CONCLUSION: The present study indicates a strong association between TCF7L2 variants and the risk of developing T2DM & DN and suggests a role of ethnicity and genetic background for susceptibility to diabetes and its complications.
Keywords: Type-2 diabetes mellitus – diabetic nephropathy – TCF7L2 Gene – single nucleotide polymorphism – real time PCR.
Article tools
My recent searches
My recently viewed abstracts
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more