ECE2018 Poster Presentations: Diabetes, Obesity and Metabolism Diabetes (to include epidemiology, pathophysiology) (73 abstracts)
Prorenin and secreted frizzled-related protein-4 levels in women with gestational diabetes mellitus
Suleyman Ipekci 1 , Suleyman Baldane 1 , Ayse Gul Kebapcilar 2 , Sedat Abusoglu 3 , Hasan Beyhekim 2 , Tolgay Tuyan Ilhan 2 , Ali Unlu 3 & Levent Kebapcilar 1
1Selcuk University, Faculty of Medicine, Division of Endocrinology and Metabolism, Konya, Turkey; 2Selcuk University, Faculty of Medicine, Department of Gynecology and Obstetrics, Konya, Turkey; 3Selcuk University, Faculty of Medicine, Department of Biochemistry, Konya, Turkey.
Background: This study was designed to investigate prorenin and secreted frizzled-related protein-4 (SFRP-4) levels in pregnancies with or without gestational diabetes mellitus (GDM).
Materials and methods: A total of 76 pregnant women were included in the study. Thirty-five of the pregnant women were included in the GDM group according to the results of oral glucose tolerance tests (OGTT) and 41 pregnant women were included in the control group.
Results: In the group with GDM, SFRP-4 value was found to be significantly higher than that of the control group (5.59±3.32 ng/ml vs 4.05±2.15 ng/ml; P=0.017). Women with GDM had significantly higher serum prorenin levels compared with control group (737 (427–1339) pg/ml vs. 535 (376–725) pg/ml, P=0.009). There was a significant positive association between prorenin and SFRP-4 levels in the GDM (r=0.91, P < 0.001) and control group (r=0.42, P=0.002) and whole pregnancies (r=0.75, P=0.002).
Conclusions: We have shown that prorenin and SFRP4 were significantly elevated in GDM patients when compared to healthy control group. Furthermore, we found that there was a positive correlation between prorenin and SFRP-4.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more