ECE2018 Poster Presentations: Diabetes, Obesity and Metabolism Diabetes therapy (43 abstracts)
The impact of different glucose-lowering regimens on cardiovascular disease in type 2 diabetes
Snezana Vujosevic , Selim Agic , Sanja Borozan , Sanja Vucetic , Sreten Kavaric , Olivera Boskovic , Aleksandar Djogo , Djordjije Krnjevic , Emir Muzurovic & Dragomir Madzgalj
Clinical Centre of Montenegro, Podgorica, Montenegro.
Introduction: American Heart Association considers diabetes mellitus (DM) to be one of seven major controllable risk factors for cardiovascular disease. At least 68% of patients age 65 or older with DM die from some form of heart disease while 16% die as a consequence of stroke. Studies conducted in patients with type 2 DM (T2DM) have not confirmed a significant association between a certain types of glucose-lowering drugs and a presence of cardiovascular events.
Aim: To establish a relationship between different treatment regimens in patients with T2DM and a presence of acute or recent cardiovascular event.
Methodology: A cross sectional population based study included patients with both T2DM and myocardial infarction- acute or in the past 1 year, that have been examined in Clinical center of Montenegro during one day. Demographic data were collected, along with a type of treatment for T2DM and current glycoregulation. Statistical analysis was performed using descriptive statistics and Student t-test.
Results: Out of 42 subjects included in study, 23 were female and 19 were male, mean age 66.78±9.67 years. Insulin therapy solely was present in 10 patients (23.8%), combined therapy in 21 (50%) and oral glucose-lowering agents in 11 (26.2%) of patients. The mean value of glycated hemoglobin (HbA1c) in groups respectively was 9.0%, 8.9% and 6.97%. No statistical significance was found between insulin and combined therapy (P=0.8691), while there were a significant statistical differences between insulin and oral therapy (P=0.0020) and combined and oral therapy (P=0.0021).
Conclusion: Glycated hemoglobin, however, could not be a valid surrogate for assessing either the cardiovascular risks or benefits related to diabetes therapy. We concerned that some glucose-lowering agents may impact greater cardiovascular risk but there is no sufficient evidence to support one drug or any combination of other drugs for the reduction of cardiovascular events.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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