ECE2018 Poster Presentations: Diabetes, Obesity and Metabolism Obesity (78 abstracts)
Deciphering the functional role of host-microbiota interactions on metabolic health induced by Roux-en-Y gastric bypass (RYGB) surgery
Julia Münzker 1 , Nadine Haase 1 , Lucas Scheffler 1 , Robert Sucher 2 , Jiesi Chen 1 , Julia Reichert 3 , Rima Chakaroun 1 , Alyce Crane 1 , Sven Haange 4 , Ulrike Rolle-Kampczyk 4 , Sjaak Riede 1 , Martin von Bergen 4 , Peter Kovacs 1 , Ute Krügel 3 & Wiebke Fenske 1
1Department of Medicine, Integrated Research and Treatment Centre for Adiposity Diseases, Leipzig, Germany; 2Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital Leipzig, Leipzig, Germany; 3Rudolf Boehm Institute of Pharmacology and Toxicology, Clinical Pharmacology, University of Leipzig, Leipzig, Germany; 4Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research, Leipzig, Germany.
Roux-en-Y gastric bypass (RYGB) surgery results in rapid weight loss, reduced adiposity and improved overall metabolism. These health benefits cannot solely be attributed to the reduced caloric intake, but the exact mechanisms are still incompletely understood. Several studies in rodents and humans demonstrated alterations of the gut microbiota following RYGB, suggesting a crucial role of the host-microbial interactions for the beneficial effects of surgery. This study aimed to assess whether the altered gut milieu composition after RYGB is necessary or even sufficient to promote beneficial effects on energy balance and metabolism in a rat model of diet-induced obesity (DIO). Pilot studies prove that the beneficial effects of RYGB on body composition, food intake and glucose homeostasis are dependent on the gut microbial composition and can be abolished via broad range antibiotic administration via drinking water. Allogenic fecal microbial transfer (FMT) from RYGB-operated to DIO animals mimics the beneficial effects on feeding, adiposity and glucose control without surgical gut reconfiguration. In contrast, FMT from metabolically healthy lean donors to DIO animals shows no beneficial effects on metabolism. These preliminary findings affirm the hypothesis that the altered gut microbiome plays an important functional role in the metabolic improvements after RYGB, and that transferring the altered RYGB-gut milieu into a DIO organism is potent enough to accomplish the beneficial metabolic effects without surgical gut reconfiguration.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more