Searchable abstracts of presentations at key conferences in endocrinology
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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

ea0056p530 | Obesity | ECE2018

Anti-insulin resistant effect of ferulic acid in high-fat diet-induced obese mice

Naowaboot Jarinyaporn , Piyabhan Pritsana

This study investigated the action of ferulic acid (FA) on the regulation of insulin sensitivity in high-fat diet (HFD)-induced obese mice. The ICR mice were fed with HFD (45 kcal% lard fat) for 16 weeks. Over the last 8 weeks of HFD feeding, these obese mice were orally administered with FA at doses of 25 and 50 mg/kg/day. At the end of all treatments, the epididymal fat, pancreas and hypothalamus were removed for analysis of biochemical parameters and expression of proteins....

ea0056p531 | Obesity | ECE2018

Non-alcoholic fatty liver disease and its association with insulin resistance in an obese population

Velde Frederique Van de , Bekaert Marlies , Hoorens Anne , Praet Marleen , Batens Arsene-Helene , Shadid Samyah , Nieuwenhove Yves Van , Lapauw Bruno

Background and aims: Obesity induced inflammation is a key component in the pathogenesis of insulin resistance (IR). In addition, obesity-related non-alcoholic fatty liver disease (NAFLD) also seems to contribute to IR development. Until now, however, it is unclear which, if any component of NAFLD specifically associates with IR. Therefore, the aim is to assess if individual components of NAFLD contribute to IR in obese patients undergoing gastric bypass surgery (GBS).<p c...

ea0056p532 | Obesity | ECE2018

Using on-line program of good nutrition and wright diet may reduce the risks of diabetes mellitus in the future

Krylov Vadim

Objectives: It is too much easier and cheaper to combat obesity, than in the future to treat diabetes mellitus and its complications.Methods: We used an online system for patient education ( based on the video lessons, full of humor, pictures, and cartoons to convey the necessary information on good nutrition, necessary to do exercises and the need for exposure to the sun to our patients.Results: A patient was in t...

ea0056p533 | Obesity | ECE2018

Effectiveness of bariatric surgery in metabolically healthy obese patients

Tuneu Laura , Ramos Analia , Genua Idoia , Stantonyonge Nicole , Caimari Francisca , Balague Carmen , Fernandez-Ananin Sonia , Perez Antonio , Minambres Inka

Objective: To evaluate the effectiveness and security of bariatric surgery in metabolically healthy obese (MHO).Methods: A retrospective study of a cohort of all obese patients who underwent to bariatric surgery with a minimum two-year follow-up. Databases of all demographic, anthropometric and metabolic characteristics have been collected since 2007. Patients undergoing two surgeries were excluded. We defined as MHO patients those without diagnosis of d...

ea0056p534 | Obesity | ECE2018

The relationship between obesity, insulin resistance and conjunctival impression cytology

Dagdeviren Murat , Altay Mustafa , Yildiz Zennure , Simsek Gulcin , Citirik Mehmet , Ates Ihsan , Dagdeviren Tanyel S , Yildiz Canan , Sahin Tugba

Introduction: This study was designed to determine whether obesity causes inflammation on both conjunctival epithelium cells as well as on squamous metaplasia.Materials and methods: Around 61 volunteer participants who had no previous history of illness or drug use were involved in this study. Of them, nearly 20 were obese, and 41 were of normal weight. We measured the glucose and insulin values for all volunteers. We also measured the Body Mass Index (B...

ea0056p535 | Obesity | ECE2018

Effect of the Andean plant Lampaya on NF-κB and JNK phosphorylation in human macrophages treated with palmitic acid.

Ormazabal Paulina , Cifuentes Mariana , Fuentes Cecilia , Paredes Adrian , Morales Glauco

Background: Adipose tissue dysfunction occurring in obesity leads to a low grade chronic inflammatory state. Fat tissue from obese individuals has a high infiltration rate of macrophages contributing to the development of obesity-related inflammation. At the cellular level, inflammation can be triggered by the activation (phosphorylation) of NF-κB as well as JNK. On the other hand, palmitic acid (PA) is a saturated fatty acid found elevated in plasma from obese subjects a...

ea0056p536 | Obesity | ECE2018

The effect of n-3 PUFA on lipid profile, inflammation and insulin resistance

Nourbakhsh Mona , Nourbakhsh Mitra , Azar Maryam Razzaghy

Insulin resistance, lipid imbalance and inflammatory process have deleterious effect on cardiovascular system. Omega-3 polyunsaturated fatty acids (n-3 PUFA) (Docosahexaenoic acid [DHA] and Eicosapentaenoic acid [EPA]) are lipids that have beneficial effects. Our objective was to study the effects of n-3PUFA on anthropometric characteristics, inflammation, lipid profile and insulin resistance of the children with obesity.Materials and methods: Thirty obe...

ea0056p537 | Obesity | ECE2018

Differences in adipocyte size and adipogenic potential in metabolically healthy and unhealthy obese bariatric surgery patients

Hristov Ioana , Tiron Crina , Tiron Adrian , Timofte Daniel , Labusca Luminita , Leustean Letitia , Oboroceanu Teodor , Mocanu Veronica

Introduction: The adipocyte expansion is a critical process with implications in the pathogenesis of metabolic syndrome and insulin resistance associated to obesity. Impaired adipogenesis leads to dysfunctional, hypertrophic adipocytes, chronic low grade inflammation and insulin resistance.Methods: Our study included 18 obese patients (13 females and 5 males) mean age 38.76±8.89 years and mean body mass index 46.06±6.48 kg/m2, referred for Lapa...

ea0056p538 | Obesity | ECE2018

Glucocorticoid positively regulate Agouti-related protein gene

Nishiyama Mitsuru , Nakayama Shuichi , Iwasaki Yasumasa , Fujimoto Shinpei , Terada Yoshio

Purpose: Glucocorticoid is one of the key hormones that regulates energy balance. Glucocorticoid excess induce hyperphagia and obesity (e.g. Cushing syndrome), however, its mechanisms are not fully elucidated. On the other hand, Agouti-related protein (AgRP) is known as an orexigenic neuropeptide, which is expressed in the hypothalamic arcuate nucleus. To clarify the role of Agouti-related protein (AgRP) in glucocorticoid-induced obesity, we investigate here the effect of gluc...

ea0056p539 | Obesity | ECE2018

Relationship between body image perception, diet trial and depression in Korean adults: Korea National Health and Nutrition Examination Survey 2014

Hong Soo Min , Koo Ho Seok , Hur Yang Im

Introduction: Previously we investigated the relationship between obesity and depression in Korean adults using data from a population-based sample from the 2014 Korea National Health and Nutritional Examination Survey (KNHANES) by cross-sectional study. We further investigated about relationship between body image perception, diet trial and depression in -depth study.Methods: In total, 4,026 subjects (1,692 men, 2,334 women) aged 19–69 years partic...

ea0056p540 | Obesity | ECE2018

Obstructive sleep apnea syndrome frequency in obese patients

Elbuken Gulsah , Yildiz Ismail , Mutlu Levent Cem , Altintas Nejat , Zuhur Sayid Shafi

Introduction: Obstructive sleep apnea syndrome (OSAS) is a common disorder whose prevalence is linked to an epidemic of obesity. OSAS is caused by recurrent episodes of upper airway obstruction during sleep, leading to reduction or cessation of the airflow. Studies have shown a strong association among OSAS and cardiovascular morbidity and mortality. Therefore, currently we performe overnight polysomnograpy in all patients with obesity in our outpatient clinic. In order to obs...

ea0056p541 | Obesity | ECE2018

Impact of bariatric surgery on working productivity in patients with morbid obesity

Romero Diana , Fidel Guila , Cepeda Maria Sonsoles , Parramon Gemma , Velasquez Mayra , Fidilio Enza Maria , Fort J M , Comas Marta , Hernandez Cristina , Simo Rafael , Mesa Jordi , Ciudin Andreea

Introduction: Morbid obesity (MO) is a major global public health problem, associated with a significant economic burden, both due to its high prevalence and the number and severity of its comorbidities. MO is associated with a high degree of difficulty to lead a normal social and working life. Weight loss is effective in decreasing these risks and to reduce disease severity. Bariatric surgery (BS) is an effective therapy for sustained weight loss and for the improvement of th...

ea0056p542 | Obesity | ECE2018

Associations of circulating adipokine levels with metabolic risk factors and renal function in a general population

Zylla Stephanie , Fischer Julian , Volzke Henry , Kassubek Jan , Kuhn Jens-Peter , Nauck Matthias , Friedrich Nele

Background, objective: Adipose tissue is known to secrete a multitude of bioactive adipokines and it seems that the majority of these adipokines is implicated in the pathogenesis of obesity and associated metabolic diseases. Existing research studies mostly concentrated on one or two adipokines and therefore, comparisons of the involvement of different adipokines in these disorders are difficult. Furthermore, associations of circulating adipokine levels with different fat comp...

ea0056p543 | Obesity | ECE2018

Association of sleep duration and obesity according to sex and age in Korean adults: results from the Korea national health and nutrition examination survey 2007–2015

Lee Mi Young , Jeong Ji Yun , Cho Eun-Hee , Kim Jung Min , Shin Mi-Seon

Background/objectives: This study aimed to investigate associations between self-reported sleep duration and general and abdominal obesity in Korean adults stratified according to sex and age.Subjects/methods: Data from 41,805 adults, 18–110 years of age, collected by the Korean National Health and Nutrition Examination Survey (KNHANES) in 2007 and 2015, were included. Obesity was defined as body mass index (BMI) ≥25 kg/m2, and abdo...

ea0056p544 | Obesity | ECE2018

Relation of serum irisin levels, non-alcoholic fatty liver disease, glucose and lipid metabolism parameters in obese children

Ulualan Gokcen , Kusku-Kiraz Zeynep , Kirel Birgul

Irisin is a myokine induced by exercise, that converts white fat tissue to brown fat tissue, thereby increasing thermogenesis and providing energy expenditure. The aim of this study is to determine the relationships between serum irisin levels and glucose and lipid parameters in obese children with and without non-alcoholic fatty liver disease (NAFLD). A total of 60 pubertal obese children (31 F, 29 M, age range: 11–18 yrs.) were included in this study. 30 of Whom had NAF...

ea0056p545 | Obesity | ECE2018

Do dietary acidic and basic amino acids intake play role in FTO gene expression among non-diabetic adults?

Asghari Golaleh , Yuzbashian Emad , Zarkesh Maryam , Mirmiran Parvin , Hedayati Mehdi , Khalaj Alireza

Introduction: The fat mass and obesity-associated gene (FTO) has been shown to be associated with obesity and might be affected by dietary factors. Long-term dietary intake of amino acids are capable to change adipose tissue metabolism through regulation of FTO production. This study aims to examining the association of dietary acidic and basic amino acids (AAs) with FTO gene expression in subcutaneous and visceral adipose tissues among non-diabetic adults.<p class="abstex...

ea0056p546 | Obesity | ECE2018

Long term dietary intake of aromatic amino acids are associated with leptin gene expression in adipose tissues of non-diabetic adults

Asghari Golaleh , Yuzbashian Emad , Zarkesh Maryam , Mirmiran Parvin , Hedayati Mehdi , Khalaj Alireza

Introduction: Among the adipokines, leptin is one of the hormones directly connects to body fat and obesity. Investigating the impacts of dietary amino acids on adipose tissue metabolism have emerged as a fascinating area for researchers which they reported that dietary amino acids can affect and regulate gene activity in adipose tissues both directly and indirectly, with positive or negative effects.Methods: Visceral and subcutaneous adipose tissues wer...

ea0056p547 | Obesity | ECE2018

Assessment of macrophage apoptosis inhibitor (AIM), monocyte chemotactic protein-1 (MCP-1) and C reactive protein (CRP) levels in patients with metabolic syndrome

Savas Emine Merve , Samadi Afshin , Baykal Hanife Seda , Unluturk Ugur , Lay Incilay , Isikhan Selen Yilmaz , Gurlek Omer Alper

Metabolic syndrome is an important health problem that has been shown to be associated with cardiovascular disease and mortality. Recent studies have shown the importance of inflammation in visceral fat tissue. Macrophage apoptosis inhibitor (AIM) and monocyte chemotactic protein (MCP-1) are molecules that cause migrating to visceral fat tissue of M1 macrophages that initiate adipocyte inflammation. The aim of this study is to understand the role of these molecules in the path...

ea0056p548 | Obesity | ECE2018

Oxidized low-density lipoprotein (oxLDL) as a possible biomarker of cardiovascular diseases in obese subjects

Parreno Elena , Fornovi Aisa , Ballester Raul , Martinez Luz , Aviles Clara , Martinez Mariana , Arjonilla Elena

Introduction: oxLDL are produced from the oxidation of low density lipoprotein (LDL) by macrophages and endothelial cells, becoming cytotoxic and immunogenic. They are also a potent inhibitor of the macrophages mobility, contributing to the vascular wall progressive inflammatory infiltration and atherosclerosis formation. Weight loss can prevent atherosclerotic plaque progression of and acute coronary events in obese subjects, so that oxLDL could be used a biomarker of cardiov...

ea0056p549 | Obesity | ECE2018

Effects on comorbidities and safety of bariatric surgery in morbid obesity patients

Schuldt Maria Belen Ojeda , Gavira Isabel Mateo , Rivero Daniel Medina , Escandon Laura Larran , Ossorio Maria Angeles Mayo , Garcia Jose Manuel Pacheco , Diosdado Manuel Aguilar

Objectives: 1) To determine the prevalence on the main comorbidities in morbid obese patients; 2) To analize the bariatric surgery effects on the comorbidities; and 3) To evaluate the complications of bariatric surgeryMethods: Cohort study with intrasubject measures (before-after) in a sample of 333 patients with morbid obesity who underwent bariatric surgery (bypass gastric or sleeve gastrectomy) in Puerta del Mar Hospital (Cádiz, Spain) between 20...

ea0056p550 | Obesity | ECE2018

Association of total antioxidant capacity and p53 mRNA levels in subcutaneous adipose tissue of obese subjects

Zarkesh Maryam , Yuzbashian Emad , Saeedpour Atoosa , Asghari Golaleh , Hedayati Mehdi , Hajizadeh Maasomeh , Mirmiran Parvin , Khalaj Alireza

Objective: Dietary total antioxidant capacity (TAC) has been assumed as a useful tool to consider the relationship between the cumulative antioxidant food capacity and several chronic disorders. The contribution of p53 to many aspects of age-associated diseases, such as cardiovascular and metabolic disorders has been recognized. The role of dietary TAC in adipose tissues metabolism especially its association with P53 gene expression is not established yet in fat mass. The aim ...

ea0056p551 | Obesity | ECE2018

Influence of lifestyle modification on leptin and insulin resistance to prevent type 2 diabetes mellitus development

Shishko Elena , Mokhort Tatyana , Mokhort Elena

The aim of the present study was to determine the change of fasting serum leptin and insulin levels and insulin resistance in patients with risk factors of diabetes mellitus of type 2 (DM 2) including impaired glucose tolerance/impaired fasting glucose (IGT/IFG).Material and methods: The study included 100 patients (32 men, 68 female) 25–65 years old at risk factors of DM 2. All patients received recommendations on a balanced diet and physical activ...

ea0056p552 | Obesity | ECE2018

Postprandial glucose, insulin, and incretin responses to different type of breads in healthy overweight and obese individuals

Kayali Merve , Tutuncu Yildiz , Ozge Duman Sebiha , Dinccag Nevin

Background: Worldwide, bread is one of the most consumed foodstuff. White bread is made of white flour and process involves the exclusion of bran and embryo. On contrary, these are preserved in whole wheath. Compared the whole grain bread, most commercial white wheat breads contain little dietary fiber and it is assumed to cause more drastic rise and fall on glucose and insulin levels.Objective: Aiming to investigate 3-hour effect of two different type o...

ea0056p553 | Obesity | ECE2018

The effects of bariatic surgery on clinical, renal parameters and urine ngal levels in diabetic and non-diabetic obese patients

Elbasan Onur , Peynirci Hande , Cander Soner , Oz Gul Ozen , Dirican Melahat , Ersoy Canan

Background: It is known that obesity-related renal damage,regardless of type 2 diabetes and hypertension, may improve by weight-loss modalities. In this study, we aimed to evaluate the effect of bariatric surgery on glycemic and lipid parameters, anthropometric measurements, renal parameters and urine NGAL (Neutrophil Gelatinase-Associated Lipocalin) levels in obese diabetic or nondiabetic patients who has not respond to medical treatmentMaterials and me...

ea0056p554 | Obesity | ECE2018

Abstract withdrawn....

ea0056p555 | Obesity | ECE2018

Are there differences in cardiovascular risk between metabolically healthy and sick obese?

Rosa Alhambra Exposito Maria , Munoz Jimenez Concepcion , Calanas Continente Alfonso , Jose Molina Puerta Maria

Introduction: Obesity is a major health problem and a risk factor for the development of other diseases. However, there are morbid obese subjects of long evolution that can be considered metabolically healthy obese, whose existence is in doubt for many clinicians.Objetive: To analyze if there are differences in cardiovascular risk between metabolically healthy (MHO) and sick obese (MSO), matched by age, sex and body mass index (BMI).<p class="abstext...

ea0056p556 | Obesity | ECE2018

Menopausal hormone therapy is associated with reduced fat mass and in particular a significant decrease of the intravisceral abdominal fat, the OsteoLaus cohort

Papadakis Georgios , Hans Didier , Vollenweider Peter , Gonzalez Rodriguez Elena , Waeber Gerard , Marques-Vidal Pedro , Lamy Olivier

Background: We previously showed that menopausal hormone therapy (MHT) favorably affects both bone density and microarchitecture with persistent benefit after its withdrawal (1). Looking for indirect factors contributing to bone effects, we investigated the relation between MHT and changes on fat and lean (muscular) tissue. Existing results on MHT and body composition are conflicting and large cohort studies are lacking.Material and methods: The OsteoLau...

ea0056p557 | Obesity | ECE2018

Effect of surgical weight loss on the inflammatory hematological parameters in short term

Nemli Hilal , Kisakol Gurcan , Devrim Kucuksarac Kiyici Sinem , Guclu Metin , Koca Nizameddin

Introduction: In obesity, MPV is found higher compared to healthy controls. It was found that the level of NLR was predictive of the development of type 2 diabetes with high sensitivity and specificity in morbid obese patients. PLR is a new biological indicator that can assess the presence and severity of inflammation. However, in obese patients PLR was not found to associate with degree of of obesity or ratio of weight loss. Regarding the platelet count (PC) in obesity, confl...

ea0056p558 | Obesity | ECE2018

Carotidintima-mediacomplexthickness and sex steroid levels in severly obese women of reproductive age

Tancic-Gajic Milina , Ivovic Miomira , Marina Ljiljana , Arizanovic Zorana , Ilievski Marija , Kendereski Aleksandra , Micic Dragan , Vujovic Svetlana

Introduction: Obesity is often accompanied by comorbidites predisposing atherosclerosis. Carotid intima-media complex thickness (CIMT) is consisdered as a marker of initial asymptomatic atherosclerosis. The relationship of sex hormones to obesity and atherosclerosis has been extensively studied.Objective: The objective of the study was to analyze the correlation CIMT and sex steroid levels in severly obese pre-menopausal women.Meth...

ea0056p559 | Obesity | ECE2018

Effect of pre-gestational weight and gestational weight gain in women with gestational diabetes controlled with medication on pregnancy outcome-is recommended weight gain too liberal?

Koren Ronit , Hochman Yuval , Koren Shlomit , Ziv-Baran Tomer , Wiener Yifat

Aim: The aim of this study was to evaluate the effect of pre-gestational body mass index (BMI) and gestational weight gain (GWG) on adverse pregnancy outcomes in women with gestational diabetes mellitus (GDM) controlled with medication.Methods: We conducted a retrospective cohort study of women with singleton pregnancies, diagnosed with GDM and treated with glucose lowering agents that were followed and gave birth between 2005–2015 in the Assaf Haro...

ea0056p560 | Obesity | ECE2018

The effects of endurance exercise training on chemerin, apelin, and visfatin in metabolically healthy obese young males

Bae Lee Sang , Hye Kim Jung , Park Kahui , Sun Nam Ji , Kang Shinae , Suk Park Jong , Woo Ahn Chul , Kim Yu-Sik

Purpose: This study investigated the exercise-induced changes in novel adipokines (visfatin, chemerin, and apelin) related to obesity and metabolism, and their correlations with the changes in the measures of obesity and glucose homeostasis after the 8-wk exercise intervention.Methods: Forty metabolically heathy obese young males were randomly assigned either to control (C, n=12) or exercise group (Ex, n=28). The subje...

ea0056p561 | Obesity | ECE2018

Absence of leptin signaling during development causes metabolic and neuronal disturbances in adult life

Donato Jr. Jose , Ramos-Lobo Angela , Furigo Isadora , Teixeira Pryscila

The hormone leptin is required for the energy balance regulation. However, leptin also controls many other biological functions. Among these actions, some authors suggest that leptin exhibits neurotrophic effects in early life and plays a key role in the development of neurocircuitries that regulate energy metabolism. However, the precise role of leptin during development is still unclear. Thus, our study had the objective to investigate the consequences of the absence of lept...

ea0056p562 | Obesity | ECE2018

The relationship between arterial stiffness and obesity in kidney transplant recipients

Ersoy Alparslan , Koca Nizameddin , Sensoy Baris , Gullulu Sumeyye , Ersoy Canan

Obesity and cardiovascular disease (CVD) risk in recipients increase after kidney transplantation due to immunosuppressive drugs, non-traditional risk factors related to immunosuppressive drugs or chronic kidney disease (CKD). Inflammation, endothelial dysfunction, arterial stiffness (AS) and vascular calcification are common complications contributed to the development of CVD in patients with CKD. We aimed to evaluate the relationship between AS and obesity in transplant reci...

ea0056p563 | Obesity | ECE2018

Anti-obesity effect of green alga sulphated polysaccharide on high fat diet

Abdallah Rihab Ben , Kolsi Boulbaba , Elleuch Mouna , Mnif Mouna , Abid Mohamed

Obesity is considered as an exceeding life style disorder notably in developing countries and it is prevailing at a frightful speed in new world countries as a result of fast food intake, causing raised blood cholesterol levels, which in turn can damage many systems in the body. The present study investigates the hypolipidemic effects of sulphated polysaccharide obtained from Codium fragile (CFSP) in induced obese rats (HFD). The results showed an increase in body weight of HF...

ea0056p564 | Obesity | ECE2018

Serum oxytocin in elderly patients with metabolic syndrome

Hosny Salwa , Bekhet Meram , Bahaaeldin Ahmed , Mahrous Mary

Background: The term metabolic syndrome refers to a cluster of associated symptoms composed of impaired fasting glucose, abdominal obesity, hypertension, and dyslipidaemia. Metabolic syndrome is associated with an increased risk of cardiovascular and diabetes-associated morbidity and mortality. Further, there is evidence that metabolic syndrome is an effective and simple clinical tool for identifying high-risk subjects predisposed to cardiovascular diseases and diabetes mellit...

ea0056p565 | Obesity | ECE2018

Study on some biochemical parameters in peripheral blood of animals upon diet-induced obesity and insulin resistance modeling

Abduvaliev Anvar , Musaeva Shakhlo , Irgasheva Sanobar , Mustafakulov Mukhammadjon , Ibragimova Elvira , Saatov Talat

The work was initiated to study some biochemical parameters in peripheral blood of animals upon diet-induced obesity and insulin resistance modeling. Obesity was induced in BALB/c mice by keeping them on the high- carbon diet for 13 weeks. The commercially available kits were used to assay glucose, alkaline phosphatase, creatine kinase and cholesterol; concentrations of testosterone were measured by the enzyme immunoassay. The high carbon diet in BALB/c mice served as a basis ...

ea0056p566 | Obesity | ECE2018

Does follicle stimulating hormone effect adiposity in patients with hypergonadotrophic hypogonadism: a retrospective study

Demirci Ibrahim , Haymana Cem , Gulcelik Nese Ersoz , Sonmez Yusuf Alper , Meric Coskun , Aydogdu Aydogan , Demir Orhan , Azal Omer

Introduction: Recent studies showed that post-menopausal osteoporosis and weight gain starts at the perimenopause stage, a period characterized by relatively stable estrogen and rising FSH levels. FSH is found to be associated with adiposity in women, which is also a great risk factor for type 2 DM. There is also a sharp increase in visceral adiposity during this life stage, which coincides with the emergence of disrupted energy balance and reduced physical activity. There is ...

ea0056p567 | Obesity | ECE2018

Psychosocial aspects and hygiene-dietetic habits in a group of patients in follow-up before bariatric surgery

Rivero Daniel Medina , Gavira Isabel Maria Mateo , Martin Amelia Rodriguez , Escandon Laura Larran , Diosdado Manuel Aguilar

Objectives: To evaluate the psychosocial aspects and the common dietary habits in a group of patients in follow-up in specific consultation of bariatric surgery prior to the intervention.Methods: Cross-sectional study of patients in follow-up in the specific morbid obesity consultation of the University Hospital Puerta del Mar (Cádiz) not intervened.Results: 110 patients were analyzed, of which 68.2% are women, with an average...

ea0056p568 | Obesity | ECE2018

Psychosocial aspects and hygiene-dietetic habits in a group of patients intervened for bariatric surgery

Rivero Daniel Medina , Gavira Isabel Maria Mateo , Martin Amelia Rodriguez , Escandon Laura Larran , Diosdado Manuel Aguiliar

Objectives: To evaluate the psychosocial aspects and the common dietary habits in a group of patients undergoing bariatric surgery.Methods: Cross-sectional study of patients in follow-up in the specific consultation of morbid obesity of the University Hospital Puerta del Mar (Cádiz) intervened, at 6–12 months of follow-up.Results: 88 patients were analyzed, of which 70.5% (N=62) are women, with an average age of ...

ea0056p569 | Obesity | ECE2018

Body mass index versus visceral adiposity index as predictors for dyslipidemia and liver stiffness in HIV/HCV co-infected patients with liver fibrosis

Garcia-Figueras-Mateos Carolina , Cayon-Blanco Manuel

Introduction: Association between liver fibrosis and body mass index (BMI) is well known in HIV/HCV patients, is linked to worse lipid profile and is widely used to predict liver fibrosis in this population. Nevertheless, recent studies show a stronger link between dyslipidemia and liver stiffness with visceral adiposity index (VAI) in general population. The main aim of this study was to investigate the accuracy of VAI and BMI as predictors for liver fibrosis and dyslipidemia...

ea0056p570 | Obesity | ECE2018

Abstract withdrawn....

ea0056p571 | Obesity | ECE2018

Effect of 8 weeks of hypocaloric diet and physical activity on thyroid hormones, irisin and insulin sensitivity in obese otherwise healthy subjects.

Penesova Adela , Bajer Boris , Radikova Zofia , Havranova Andrea , Imrich Richard , Vlcek Miroslav

Hypothyroidism is associated with modest weight gain, but there is a lack of clarity regarding subclinical hypothyroidism and obesity. Studies with bariatric surgery showed that 15–25% of extremely obese subjects had subclinical hypothyroidism. Therefore the goal of this study was to evaluate the effect of intensified life style intervention on insulin sensitivity, irisin concentration and thyroid function parameters.Methods: A randomized i...

ea0056p572 | Obesity | ECE2018

The comparison of different obesity criterias in kidney transplant recipients

Ersoy Alparslan , Arslan Ilknur , Gul Ozen Oz , Cander Soner , Ersoy Canan

Weight gain and obesity are frequent problems after kidney transplantation. Potential causes of weight gain are use of immunosuppressive drugs and changes in life style such as dietary intake and insufficient physical activity. This study aimed to evaluate the different general and abdominal obesity criterias and post-transplant weight changes in kidney transplant recipients.Methods: This prospective study included consecutive 112 (62 females, 50 males) ...

ea0056p573 | Obesity | ECE2018

Effect of the rs12324955 polymorphism of the FTO gene in the intervention for the weight reduction in obese patients with the use of technological resources

Martin-Portugues Antonio Ballesteros , Cano Susana Rodrigo , Rodrigo Susana Tenes , Azorin Carolina Ortega , Marquez Eva Maria Asensio , Guerola Jose Vicente Sorli , Corella Piquer Dolores , Torres Juan Francisco Merino

Introduction: Obesity is a multifactorial disease in whose genetic factors are involved. The integration of this factors will allow to state personalized prevention strategies, where the constant contact with the patient will have a greater success for them to follow up recommendations. Continuous technological changes allow bigger accessibility to communication, having platforms with remote control.Objective: Assessing the effectiveness of an Intelligen...

ea0056p574 | Obesity | ECE2018

Novel indicator of abdominal obesity strongly associated with cardiovascular disease

Kim Dong Sun , Park Jung Hwan , Ryu Ohk-Hyun , Chung Wankyo , Moon Shinje

Obesity is one of the leading causes of elevated cardiovascular disease (CVD) mortality and morbidity. Several indicators of abdominal obesity such as body mass index (BMI) and waist circumference (WC) are available. BMI and WC have limitations in stratifying cardio-metabolic risks. Another obesity measure, A Body Shape Index (ABSI), has been introduced but its applicability remains limited. To address this, the z-score of the log-transformed ABSI (LBSIZ) was recently develope...

ea0056p575 | Obesity | ECE2018

The effect of laparoscopic sleeve gastrectomy on kidney function

Leca Bianca , Sava Elisabeta , Soare Iulia , Martin Sorina , Smeu Bogdan , Copaescu Catalin , Sirbu Anca , Fica Simona

Introduction: Higher body mass index (BMI) has been associated with adverse renal outcomes, including chronic kidney disease (CKD), progression to end-stage renal disease (ESRD), nephrolithiasis and renal cell cancer. Several studies have shown that weight loss following bariatric surgery has a positive effect on kidney function, mediated by a reduction in proteinuria, glomerular hyperfiltration and improvements in blood pressure and insulin resistance. The aim of this study w...

ea0056p576 | Obesity | ECE2018

Prevalence and pathophysiology of early dumping in patients after primary Roux-en-Y gastric bypass during a mixed meal tolerance test

Wijma Ragnild , Emous Marloes , Totte Erik , van den Broek Merel , Wolthuis Albert , Laskewitz Anke , Muller-Kobold Anneke , Wolffenbuttel Bruce , van Beek Andre

Introduction: The endocrinologist is confronted with an increasingly large population of postbariatric patients who present with endocrine problems. One of these is early dumping, a complication that may be the result of increased entero-endocrine activity. To address the prevalence of early dumping and to gain further insight into its pathophysiology, we performed a Mixed Meal Tolerance Test (MMTT) in a random sample of patients after Roux-en-Y gastric bypass (RYGB).<p cl...

ea0056p577 | Obesity | ECE2018

Weight loss and metabolic parameters after laparoscopic sleeve gastrectomy

Sava Elisabeta , Leca Bianca , Sirbu Anca , Soare Iulia , Martin Sorina , Smeu Bogdan , Copaescu Catalin , Fica Simona

Introduction: Obesity, defined as a BMI ≥30 kg/m2, is the most common chronic metabolic disease in the world and its prevalence has strongly increased. Obesity is associated with multiple comorbidities, including cardiovascular disease, hypertension, insulin resistance, dyslipidemia, type 2 diabetes, sleep apnea and certain cancers. Bariatric surgery is the most effective treatment for severe obesity and produces dramatic and durable weight loss. The ...

ea0056p578 | Obesity | ECE2018

Anthropometric and body composition evolution in individuals in weight loss

Sousa Bruno

Introduction: A large proportion of the Portuguese population has overweight and the process of weight loss is often focused solely on weight. However, it is essential that there is a good evolution of the body composition, namely in the decrease of fat.Objective: Evaluate the anthropometric and body composition evolution in a group of individuals followed for a weight loss.Methodology: This sample consisted of 30 adult and who wer...

ea0056p579 | Obesity | ECE2018

Free and dipeptide forms of L-glutamine supplementation attenuate parameters of oxidative stress and nonalcoholic fatty liver disease (NAFLD), and improve glucose metabolism in insulin resistant Ob/Ob mice

Leite Jaqueline Santos Moreira , Takahashi Hilton , de Araujo Layanne Cabral da C , Junior Jose Donato , Cruzat Vinicius Fernandes , Carpinelli Angelo Rafael

Introduction: The availability of the body’s most abundant amino acid, glutamine is compromised in obesity-associated diabetes. This may impair glucose metabolism by increasing hepatic insulin resistance, oxidative stress and the development of nonalcoholic fatty liver disease (NAFLD).Objective: Evaluate the effects of free and dipeptide (DIP, L-alanyl-L-glutamine) forms of L-glutamine on glucose metaboli...

ea0056p580 | Obesity | ECE2018

Role of IGF1 in regulation of SOD 1 expression and mTOR/S6K signaling in heart of obese male rats

Obradovic Milan , Stanimirovic Julijana , Panic Anastasija , Zafirovic Sonja , Isenovic Esma

Aim: Obesity is associated with activation of mammalian target of rapamycin (mTOR)/ ribosomal S6 kinase (S6K) signaling pathway that promotes cardiac hypertrophy, insulin resistance, endothelial dysfunction and oxidative stress. Although activation of mTOR/S6K has a harmful effect, simultaneously it represents adaptive metabolic response that protects cells from excessive nutrient intake. Insulin like growth factor-1 (IGF1) exerts pleiotropic action on heart promoting vasorela...

ea0056p581 | Obesity | ECE2018

Plasma metabolomic markers of insulin resistance in humans.

Pivovarova Olga , Gahwiler Roman , Nikiforova Viktoria , von Loffelholz Christian , Lisec Jan , Erban Alexander , Zerkiebel Nic , Willmitzer Lothar , Pfeiffer Andreas F H , Weickert Martin O , Rudovich Natalia N

Introduction: Insulin resistance (IR), a pathological state of low sensitivity to insulin in humans and animlas, is closely associated with type 2 diabetes mellitus, obesity and cardiovasculare dieseas. IR can be quantified using detailed protocols, such as the euglycemic-hyperinsulinemic clamp (EC) technique and the intravenous glucose tolerance test, or based on indices derived from the oral glucose tolerance test. Although these indices showed greater association with the i...

ea0056p582 | Obesity | ECE2018

“A new life in a new body”: the evolution of pregnancy following bariatric surgery in obese females

Arevalo Mayra Velasquez , Fidilio Enzamaria , Guerrero Mireia , Castillejo Neus , Comas Marta , Goya Maria , Gonzalez Oscar , Mesa Jordi , Hernandez Cristina , Simo Rafael , Ciudin Andreea

Introduction: Maternal obesity (MO) increases the risk of gestational and neonatal complications. Bariatric surgery (BS) is currently the most effective long-term treatment of MO. The sustained weight loss after BS reduces the risk of maternal comorbidities during pregnancy. Nevertheless, BS is associated with an important risk of nutrients deficiency, and some data indicate that might increase the risk of prematurity and low birth weight. The objective of the present study is...

ea0056p583 | Obesity | ECE2018

Temporal analysis of the HFD consumption in the mice small intestine physiology: possible correlation between metabolic disorders and HFD-induced obesity

Coutinho Camille Perella , Alba-Loureiro Tatiana Carolina , Hijo Andressa Harumi Torelli , Goulart-Silva Francemilson

Introduction and aim: Obesity is a public health problem characterized by metabolic and endocrine disorders. Currently, it has been observed an increase of the obesity induced by high fat diet (HFD) and, considering that small intestine is the most important absorptive site of the nutrients, it is very interesting to evaluate the impact of HFD intake on that first place of nutrients entry, that is, the small intestine. Taken into account that dyslipidemia and hypertension are ...

ea0056p584 | Obesity | ECE2018

Effect of gastrointestinal hormones on bone metabolism after bariatric surgery

Vilarrasa Nuria , Simo-Servat Andreu , Casajoana Anna , Guerrero-Perez Fernando , Gomez-Vaquero Carmen , Martinez Eva , Virgili Nuria , Lopez-Urdiales Rafael , Fernandez-Veledo Sonia , Vendrell Joan

Introduction: In vitro and animal studies have suggested that changes in the secretion of ghrelin, PYY, GLP-1, GLP-2 can influence bone metabolism. An increase in osteoblastic differentiation has been observed after the administration of ghrelin and GLP-1. GLP-2 has been associated with a decrease in bone resorption and PYY inversely with markers of bone formation.Objective: To analyze the association of gastrointestinal hormones with changes in...

ea0056p585 | Obesity | ECE2018

Relationship between human adipose tissue autophagy, obesity and glycemic status

Clemente-Postigo Mercedes , Coin-Araguez Leticia , Lhamyani Said , Gentile Adriana-Mariel , Alcaide-Torres Juan , bekay Rajaa El , Tinahones Francisco J

Introduction and aims: Autophagy is an essential process for cell homeostasis that implies recycling and degradation of damaged organelles and long-lived proteins. It is induced during caloric restriction (in order to obtain energy) or other stress-inducing conditions. Autophagy is initiated by autophagosome formation, a double-membrane vesicle which engulfs cellular components and delivers them for degradation by fusing with lysosomes. Thus, proper autophagy regulation favour...

ea0056p586 | Obesity | ECE2018

A newly inflammatory marker in overweight patients: triggering receptor expressed on myeloid cellls-1

Cifci Aydin , Durmaz Senay Arikan , Oklu Kubra , Katar Didem , Boyunaga Hakan , Badem Nermin Dindar

Introduction and aims: Triggering receptor expressed on myeloid cells 1 (TREM-1) is secreted by macrophage and neutrophils in adipose tissue to released pro-inflammatory chemokines and cytokines. TREM-1 activate Janus kinase 2 (JAK2), protein kinase B (PKB/AKT) and extracellular signal related kinase (ERK1/2) pathways and upregulate the expression of genes involved in the inflammatory response. We aimed to indicate associations with serum TREM-1 levels, total sulfhydryl (SH) a...

ea0056p587 | Obesity | ECE2018

Pre-operative evaluation of obese patients admitted for bariatric surgery: observations suggesting the introduction of a detailed screening for thyroid diseases

Gallo Daniela , Ippolito Silvia , Sabatino Jessica , Veronesi Giovanni , Frattini Francesco , Dozio Eugenia , Trotti Eugenia , Cortinovis Valeria , Giussani Federico , Lai Adriana , Sassi Lorenza , Tanda Maria Laura , Ferrario Marco , Bartalena Luigi , Piantanida Eliana

Background: So far, guidelines for bariatric surgery do no recommend the universal screening for thyroid diseases, except the TSH measurement in selected patients. However, a possible interplay between obesity (possibly complicated by obesity-related comorbidities) and thyroid diseases has been postulated.Objective: Aim of the study was to investigate the prevalence of thyroid diseases in a cohort of obese patients, evaluated for bariatric surgery. Metho...

ea0056p588 | Obesity | ECE2018

Strength training results in reduced fat accumulation and improved blood lipid profile even in the absence of skeletal muscle hypertrophy in obese rats induced by high-fat diet

Contreiro Catarina , Damiani Andressa , Caldas Leonardo , Nogueira Breno , Leopoldo Andre , Lima-Leopoldo Ana Paula , Guimaraes-Ferreira Lucas

Obesity is a chronic multifactorial disease characterized by accumulation of body fat and is associated with a number of comorbidities, such as diabetes and cardiovascular disease. The treatment of obesity depends to the severity of the disease, however, healthy eating with caloric restriction and physical activity are important strategies. In the present study, we aimed to evaluate the effect of obesity associated with strength training on skeletal muscle morphology, body adi...

ea0056p589 | Obesity | ECE2018

Association between Leptin gene polymorphisms and plasma leptin level in three consanguineous families with obesity

Fourati Mouna , Hadjkacem Faten , Ghorbel Dorra , Mrabet Houcem Elomma , Sessi Salwa , Fakhfakh Faiza , Abid Mohamed

Leptin (LEP) gene is one of the most promising candidate genes for obesity. The aim of this study was to investigate the impact of LEP polymorphisms on obesity, anthropometric and biochemical parameters in a sample of three Tunisian consanguineous families with obesity. Seven single nucleotide polymorphisms (SNPs) in 5′ region of LEP gene were genotyped in three consanguineous families including 33 individuals. The previously reported LEP</...

ea0056p590 | Obesity | ECE2018

Quality of life after sleeve gastrectomy

Omri Marwa , Mahjoub Faten , Amor Nadia Ben , Kacem Awatef , Bhouri Sabeh , Jamoussi Henda

Aim: Morbid obesity associated with obesity-related diseases has a negative impact on the quality of life. The aim of the study was to assess the impact of bariatric treatment on the quality of life among patients with morbid obesity who underwent sleeve gastrectomy.Methodology: Thirty obese patients undergoing sleeve gastrectomy were included in our study. Their weight, height, body mass index were measured at baseline and 6 months after surgery. The qu...

ea0056p591 | Obesity | ECE2018

Folic acid status in morbidly obese patients seeking sleeve gastrectomy

Omri Marwa , Mahjoub Faten , Bibi Amina , Bhouri Sabeh , Kacem Awatef , Jamoussi Henda

Background: A high prevalence of vitamin deficiencies in obese subjects has been reported. Bariatric surgery is the most effective long-term treatment of morbid obesity, but this treatment can result in secondary vitamin deficiency.Aim: The aim of our study was to evaluate the folic acid status in obese patients before sleeve gastrectomy.Methods: This was a descriptive study including a population of obese patients reffered to our ...

ea0056p592 | Obesity | ECE2018

Activation of p53 with low doses doxorubicin reduce the acumulation of lipids in two in vitro models of liver steatosis

Fernandez Fondevila Marcos , Porteiro Coto Begona , Buque Xabier , Jesus Gonzalez Rellan Maria , Fernandez Paz Uxia , Mora Alfonso , Beiroa Daniel , Senra Ana , Gallego Rosalia , Lopez Miguel , Sabio Guadalupe , Dieguez Carlos , Aspichueta Patricia , Nogueiras Pozo Ruben

Introduction: p53 is transcription factor widely known because of its antitumoral actions. New evidences suggest that p53 also play a key role in the regulation of metabolic homeostasis and specifically in the lipid metabolism.Objective: We hypothesize that the chemical activation of p53 with low doses of doxorubicin could ameliorate the lipid metabolism in in vitro models of liver steatosis.Methods: We treated with low co...

ea0056p593 | Obesity | ECE2018

Association of dietary factors and dynamic thiol/disulphide homeostasis in subjects with coronary artery disease

Bilici Salman Reyhan , Ersoz Gulcelik Nese , Omma Tulay

Background: Enviromental factors such as life style changes and dieatary factors become more important on the background of coronary artery disease (CAD). The thiols were the main part of the non-enzymatic antioxidant system in the body and they are the first defensive molecules in elimination of oxidant agents. As a result, thiol levels may be an earlier indicator for CAD. There is limited data on the relation of dietary factors with thiol/disulfide homeostasis in patients wi...

ea0056p594 | Obesity | ECE2018

Effects of a combined lifestyle intervention on anthropometric parameters and long-term cortisol after 10 and 75 weeks: a longitudinal study

Janmaat Simone , Savas Mesut , Wester Vincent , van der Valk Eline , van den Akker Erica , de Rijke Yolanda , van Rossum Elisabeth

Introduction: The prevalence of obesity is still increasing and is accompanied by significant health problems. High exposure to glucocorticoids, including the stress hormone cortisol, has been suggested to play a role in the development of obesity and associated cardiometabolic derangements. We previously showed that obese persons are exposed to high long-term cortisol levels as measured in scalp hair. It is not known whether these elevated cortisol levels decrease with weight...

ea0056p595 | Obesity | ECE2018

The preoperative diagnosis of type 2 diabetes in the absence of antidiabetic treatment is associated with a worse performance after gastric-bypass compared to patients without diabetes

Gargallo Javier , Laguna Sara , Llavero Maria , Perdomo Carolina M , Valenti Victor , Escalada Javier , Gomez-Ambrosi Javier , Silva Camilo , Fruhbeck Gema , Salvador Javier

Objectives and methods: The mechanism that explains the different weight response to various treatments in obese type 2 diabetes (DM2) patients, compared to those without diabetes, is still unknown. In order to establish the weight response to Roux-en-Y Gastric Bypass (RYGB), 268 patients with morbid obesity (IMC 45.4±0.4 kg/m2) were classified by OGTT as having normal glucose tolerance (Grupo A. n=107), prediabetes (Grupo B. n=96) an...

ea0056p596 | Obesity | ECE2018

Investigation of the effect of dietary fat content on obesity and metabolic syndrome in smokers

Bilici Salman Reyhan , Ersoz Gulcelik Nese , Omma Tulay

Background: Despite the efforts to reduce smoking, unfortunately there is a common belief in society to avoid smoking cessation or quitting smoking for weight control. As well as many negative effects of smoking, people continue to smoke instead of diet and life change. Nicotine plus high fat diet (HFD) induces intramyocellular lipid accumulation and mitochondrial abnormalities in obese mice. There is limited data in the relation of dietary fat content and metabolic syndrome i...

ea0056p597 | Obesity | ECE2018

Food addiction: its prevalence among obese patients

Ilham Bouizammarne , Mghari Ghizlane El , Ansari Nawal El

Introduction: The concept of food addiction, which refers to people who exhibit signs of dependence to some high-fat and high-sugar foods, was recently proposed by applying DSM criteria of substance dependence to eating behavior. The Aim of This study is to assess the prevalence of food addiction among obese patients.Material and methods: This is a retrospective hospital record-based study of obese patients followed up in the day hospit...

ea0056p598 | Obesity | ECE2018

Abstract withdrawn....

ea0056p599 | Obesity | ECE2018

Deciphering the functional role of host-microbiota interactions on metabolic health induced by Roux-en-Y gastric bypass (RYGB) surgery

Munzker Julia , Haase Nadine , Scheffler Lucas , Sucher Robert , Chen Jiesi , Reichert Julia , Chakaroun Rima , Crane Alyce , Haange Sven , Rolle-Kampczyk Ulrike , Riede Sjaak , von Bergen Martin , Kovacs Peter , Krugel Ute , Fenske Wiebke

Roux-en-Y gastric bypass (RYGB) surgery results in rapid weight loss, reduced adiposity and improved overall metabolism. These health benefits cannot solely be attributed to the reduced caloric intake, but the exact mechanisms are still incompletely understood. Several studies in rodents and humans demonstrated alterations of the gut microbiota following RYGB, suggesting a crucial role of the host-microbial interactions for the beneficial effects of surgery. This study aimed t...

ea0056p600 | Obesity | ECE2018

Obesity and dementia: the misleading “obesity paradox”

Pane Adriana , Pegueroles Jordi , Ruiz Sabina , Videla Laura , Carmona-Iragui Maria , Vilaplana Eduard , Montal Victor , Casajoana Anna , Vidal Josep , Fortea Juan , Jimenez Amanda

Background: Mid-life obesity is a risk factor for Alzheimer’s disease (AD). On the contrary, late-life obesity has been identified as a protective factor for dementia. Recent published studies have shown that weight loss predicts and precedes dementia diagnosis by decades. Thus, paradoxical effect of body weight across lifespan, the so called “obesity paradox”, might be explained by reverse causality. Structural magnetic resonance imaging (MRI) has been extensiv...

ea0056p601 | Obesity | ECE2018

Influence of body weight loss on gait and stability function in patients with obesity

Vasileva Valeriia , Marchenkova Larisa , Eryomushkin Michail

Objective: In our research we studied changes of gait and balance parameters and falls frequency in obese patients during weight loss.Materials and methods: We examined 37 patients aged 23–69 years (average age 53.6±11.1 years) with BMI ≥35 kg/m2 (average BMI 40.9±9.3 kg/m2). All patients received recommendations to adhere hypocaloric diet and perform physical exercises in order to reduce body weight. We evaluat...

ea0056p602 | Obesity | ECE2018

Magnetic resonance imaging of human supraclavicular brown adipose tissue

Gashi Gani , Madoerin Philipp , Maushart Claudia Irene , Michel Regina , Senn Jael Rut , Bieri Oliver , Johannes Betz Matthias

Background: Imaging of brown adipose tissue (BAT) is currently performed with combined positron emission tomography and x-ray computed tomography (PET-CT). Recent studies showed promising imaging features of BAT with magnetic resonance imaging (MRI) through modified 2-point-dixon (mDixon) water-fat separation method. The aim of this study was to establish a reliable MRI-procedure for quantification of BAT volumes and weighted fat-fraction (WFF) and to correlate them to cold-in...

ea0056p603 | Obesity | ECE2018

Benign symmetric lipomatosis (Madelung’s disease)

Oliveira-Filho Antonio F , Velloso Renata N , Oliveira Sofia NP , Medeiros Paula FV , Nunes Adriana B

Multiple benign symmetric lipomatosis (Madelung’s disease, Launois–Bensaude syndrome) is significantly rare disease characterised by symmetrical focal deposition of adipose tissue in the neck, upper part of the arms, back, pelvis, and thigh. Although its etiology is uncertain, it has been associated with genetic factors, mitochondrial inheritance and alcoholism. Its pathogenesis seems to include a dysfunction of cAMP and levels of catecholamines in adipocytes. This c...

ea0056p604 | Obesity | ECE2018

DXA Body Composition with Visceral Fat analysis improves categorization of the metabolic diseases risk

Gregorio Silvana Di , Horsch Lara , Costamagna Cecilia , Villavicencio Roberto

Introduction: Many people suffered diverse diseases associated to central obesity. Actually the most frequent tool to estimate the abdominal fat is waist perimeter. In the past and the DXA software was adapted to measure fat content in abdominal region but the visceral and subcutaneous fat couldn’t be differentiated.Objective: Evaluate all tools available and establish the most sensible to discriminate the patients whose had risk to suffer metabolic...

ea0056p605 | Obesity | ECE2018

Influence of sleeve gastrectomy on leptin to adiponectin ratio in severely obese adults: A prospective cohort study

Rafey Mohammed Faraz , Fang Clarissa Ern Hui , Ioana Iulia , Griffin Helena , Hynes Mary , O'brien Timothy , Mcanena Oliver , O'shea Paula , Collins Chris , Finucane Francis Martin

Background: Bariatric surgery is known to dramatically increase insulin sensitivity in severely obese adults. However quantifying insulin sensitivity in these patients with methods such as the hyperinsulinaemic euglycaemic clamp is technically challenging. The leptin to adiponectin ratio (LAR) has previously been validated as a measure of whole body insulin sensitivity. Leptin is a known mediator of metabolic and cardiovascular complications of obesity. Adiponectin has anti-at...

ea0056p606 | Obesity | ECE2018

Differences in percentage of weight loss and secondary effects after one and two months of treatment with liraglutide versus naltrexone/bupropion

Voltas Arribas Beatriz , Juan Carlos Sanchez , Garcia Juan Carlos Ferrer , Fullana Ana Artero , Revert Pablo Sanz , Alacid Cristian Marco , Merseguer Mario Lopez

Introduction: Obesity is one of the most prevalent health problems in our society. The marketing of Liraglutide and the Naltrexone/Bupropion combination has been given the green light.Objectives: To analyze the differences in a series of 19 patients assigned to treatment with Liraglutide or Naltrexone/Bupropion.Material and methods: A descriptive analysis was carried out using Stata. 19 patients were included, 9 were treated with L...

ea0056p607 | Obesity | ECE2018

Prevalence of obesity in a population of patients with HIV: relationship with clinical lipodistrophy, effect of sex, age, viral replication, duration of disease and cart

Guerreiro Vanessa , Neves Joao , Serrao Rosario , Sarmento Antonio , Carvalho David , Freitas Paula

Introduction: Adipose tissue disturbances (lipodystrophy and obesity) are prevalent in patients infected with HIV. Our aims were to evaluate the prevalence of obesity and the association with lipodystrophy, the effect of gender, age, viral replication, duration of disease and cART in a population of HIV patients under cART.Methods: In this retrospective study, 580 patients were included. The characteristics of the population are presented through percent...