Searchable abstracts of presentations at key conferences in endocrinology
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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

Poster Presentations: Diabetes, Obesity and Metabolism

Nuclear receptors and Signal transduction

ea0056p527 | Nuclear receptors and Signal transduction | ECE2018

Calbindin-d9k interacts with Mucin1, which influences the stability of Hypoxia inducible factor-1a

Lee Bonn , Ahn Changhwan , Viet Ly Duc , Jeung Eui-bae

Introduction: Hypoxia is involved with various physiological activities from glucose metabolism to tumor suppression. Hypoxia-inducible factor (HIF) is known as master regulator of oxygen homeostasis that triggers more than 1,000 related gene expressions. When hypoxia occurs, HIF1a protein is stabilized and starts transcription. Mucin1 mediates the stabilization of HIF1a in a cytoplasm. In addition, cytoplasmic domain of mucin1 and HIf1a form a transcriptional complex at glyco...

ea0056p528 | Nuclear receptors and Signal transduction | ECE2018

Genotype- Phenotype correlations of TNF-α, IL-6 and Leptin receptor gene polymorphisms in Poly cystic ovarian syndrome

B Rajesh , B Ramesh , G Gayathri , M Venkateshwara Reddy , D Vighnesh , B Rajkiran Reddy , B Chakrapani , PRK Bhargav

Introduction: Tumor necrosis factor alpha (TNF-α) and Interleukin-6 (IL-6) are potent immunomodulators and proinflammatory cytokines displaying varied functions. Apart from monocytes/macrophages, they are also produced by the cells in female reproductive tract. Polycystic ovarian syndrome (PCOS) is one of the commonest endocrine disorder amongst women of reproductive age group. Several polymorphisms in the promoter region of the gene TNF-α, IL-6 and Leptin receptors ...

ea0056p529 | Nuclear receptors and Signal transduction | ECE2018

Association of habitual physical activity with leptin gene expression in visceral and subcutaneous adipose tissues among non-diabetic people

Mahmoodi Behnaz , Yuzbashian Emad , Zarkesh Maryam , Asghari Golaleh , Hedayati Mehdi , Mirmiran Parvin , Khalaj Alireza

Introduction: Adipocytokines secreted by adipose tissue are suggested to play a role in the development of obesity-related complications. Leptin is mainly produced and secreted by adipose tissue and appears as an important regulator of energy balance. The relationship between leptin levels and energy expenditure remain unclear. Energy expenditure related to physical activity (PA) is the most variable part of total energy expenditure. There is some evidence tha...