Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2018) 56 P612 | DOI: 10.1530/endoabs.56.P612

ECE2018 Poster Presentations: Diabetes, Obesity and Metabolism Thyroid cancer (1 abstracts)

A case of diabetic patient with recurrent ketosis after U-300 glargine treatment

Tuğçe Ulaşli 1 , Aşkin Güngüneş 2 & Şenay Arikan Durmaz 2

1Department of Internal Medicine School of Medicine, Kirikkale, Turkey; 2Department of Endocrinology of School of Medcine, Kirikkale, Turkey.

Introduction: U-300 glargine is a new generation long acting insulin. Nocturnal hypoglicemia and weight gain with U-300 glargine is lower than U-100 glargine. However, it may take 3–4 days for U-300 glargine to reach stable state in plasma. We report a diabetic case with recurrent ketosis after U-300 glargine.

Case presentation: A 20 years old woman with type 1 diabetes mellitus who uses basal and bolus insulin (U-300 glargine and insülin aspart). She applied to emergency clinic with stomachache, diarrhea and nausea. The patient did not use insulin for a few days because of these complaints. As a laboratory results, plasma glucose concentration: 380 mg/dl, 3 positive ketones in urine analysis, PH: 7,07 in venous blood gas analysis, HCO3: 6 mmol/L. She was hospitalized in intensive care unit with diabetic ketoacidosis. Diabetic ketoasidosis improved after fluid, electrolyte replacement and insulin treatment. Urine examination showed ketones to be negative We started her routine basal- bolus insulin treatment with U-300 insulin glargine and insülin aspart. We observed again ketones (+2 positive) in urine analysis 10 hours later under her routine basal bolus treatment.

Conclusion: U300 glargine use may be associated with ketosis relapse in early period after diabetic ketoacidosis has improved, in this respect the physician must be careful.

Volume 56

20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

European Society of Endocrinology 

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