Introduction: Graves disease (GD) is one of the commonest organ specific autoimmune thyroid disease. Surgical thyroidectomy is one of the definitive treatment modalities. Autoimmunity has been implicated as one of the main cause of GD. In this context, we set out study the role of Pro- inflammatory cytokines in GD.
Material and methods: This prospective case-control study was conducted on surgically managed GD patients. Institutional ethical committee approval was obtained. Diagnosis of GD was based on clinical picture, thyroid function tests, radionuclide scanning and histopathology. Exclusion criteria were subjects any systemic or chronic inflammatory disease or any medication which interferes with the normal function of the hypothalamic-pituitary-gonadal axis. Serum samples were collected from 32 GD subjects and 30 age matched healthy controls. Interleukin-6 (IL-6), Tumour necrosis factor-alpha (TNF-α) and high sensitive C reactive protein (hsCRP), Leptin levels were measured in all serum samples. Statistical analysis was performed by one way ANOVA with Dunnets test and Pearson correlation tests.
Results: The mean hSCRP level in GD and controls were 16.6±2.1 mg/mL and 5.8±1.1 mg/mL respectively. The mean TNF-α level, IL-6 level and Leptin levels were 256±21 pg/mL, 11.4±3.2 pg/mL and 27.5±4.4 ng/mL respectively. There was statistically significant difference of all the pro-inflammatory cytokines compared to controls (P value < 0.05).
Conclusions: This study shows raised titers of pro-inflammatory markers IL-6, TNF-α and hsCRP, leptin correlated with GD suggesting a contributory role. But, the exact immuno-modulatory role and pathogenetic mechanism needs active research.
(Key words: Graves disease, Tumour necrosis factor, Interleukin-6, Goiter, Auto-immunity, Leptin)
19 - 22 May 2018
European Society of Endocrinology