ECE2018 Poster Presentations: Reproductive Endocrinology Female Reproduction (48 abstracts)
Hormonal and metabolic differences between hyperandrogenic women with PCOS
Ivana Bozic-Antic 1 , Dusan Ilic 1 , Jelica Bjekic-Macut 2 , Danijela Vojnovic-Milutinovic 3 , Olivera Stanojlovic 4 , Bojana Popovic 1 , Tamara Bogavac 1 , Tatjana Isailovic 1 , Valentina Elezovic-Kovacevic 1 , Sanja Ognjanovic 1 & Djuro Macut 1
1Clinic of Endocrinology, Diabetes and Metabolic Diseases, Clinial Center of Serbia, Belgrade, Serbia; 2CHC Bezanijska kosa, Belgrade, Serbia; 3IBISS, University of Belgrade, Belgrade, Serbia; 4Institute of Physiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Introduction: Hyperandrogenism (HA) is frequent but not universal characteristic in women with polycistic ovary syndrome (PCOS). According to the ESHRE/ASRM definition, hyperandrogenism criterion could be clinical (hirsutism) and/or biochemical (hiperandrogenemia). The aim of this study was to analyze metabolic and hormonal characteristics among women with PCOS with different forms of hyperandrogenism.
Methods: We analyzed 458 women with PCOS diagnosed using ESHRE/ASRM criteria and divided into three groups: 1) with clinical HA only (PCOS-CHA:N=67, age: 26.7±5.6 years, BMI: 23.6±5.2 kg/m2), 2) with biochemical HA only (PCOS-BHA:N=151, age: 25.5±5.3 years, BMI: 24.5±6.5 kg/m2), 3) with both clinical and biochemical HA (PCOS-CBHA:N=240, age: 25.0±5.2 years, BMI: 26.4±6.2 kg/m2), and 104 healthy controls (age:29.2±5.8 years, BMI: 25.4±16.8 kg/m2). CHA was defined as Ferriman-Gallwey score ≥8, BHA as presence of FAI≥6% and/or testososterone >2 nmol/l. We measured fasting glucose (FG), insulin, lipids, FSH, LH, testosterone, SHBG, androstenedione, estradiol, DHEAS and 17OHprogesterone, while HOMA-IR and FAI were calculated. Differences between-groups were age and BMI adjusted.
Results: In comparison to controls, PCOS-BHA and PCOS-CBHA had higher total cholesterol (TC) (P=0.031 and P=0.001, respectively), LH (P<0.001 and P<0.001, respectively), DHEAS (both P<0.001), all PCOS groups had higher triglycerides (P=0.006, P=0.004, P=0.001 respectively), PCOS-CBHA had higher 17Ohprogesterone (P=0.012) and PCOS-CHA had higher androstenedione (P=0.027). In comparison to PCOS-CHA, PCOS-BHA and PCOS-CBHA had higher LH (P=0.001 and P=0.026, respectively) and PCOS-CBHA had higher 17OHprogesterone (P=0.030) and TC (P=0.001). There were no between-groups differences in HOMA-IR, FSH and estradiol. Significant correlations was found among CHA between androstenedione and HOMA-IR (r=0.33, P=0.04).
Conclusions: PCOS with different forms of hyperandrogenism present with different cardiometabolic risk factors and different hormone profiles. Women with hirsutism and without hyperandrogenemia have less severe metabolic and hormonal status.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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