Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2018) 56 S20.3 | DOI: 10.1530/endoabs.56.S20.3

ECE2018 Symposia All you need to know about lipodystrophy (Endorsed by Endocrine Connections) (3 abstracts)

Lipodystrophies, diagnosis and treatment: a step-by-step approach

David Araujo-Vilar


Spain.


Lipodystrophy syndromes are rare heterogeneous disorders characterized by deficiency of adipose tissue, and, frequently associated, but not always, to severe metabolic abnormalities including diabetes mellitus and dyslipidemia. With the exception of HIV-associated lipodystrophy, the other distinct subtypes of lipodystrophy are very infrequent, so they are considered rare diseases. Lipodystrophy is classified as genetic or acquired and by the distribution of fat loss, which can be generalized or partial. In generalized lipodystrophy, adipose tissue is almost absent in patients, whereas in partial lipodystrophy, lipoatrophy affects only specific anatomical sites, and in some cases, lipohypertrophy appears in other sites. Genetic lipodystrophies include Berardinelli-Seip syndrome and Familial Partial Lipodystrophy, but also many different early aging syndromes (progerias) and specific auto-inflammatory syndromes. In this cases, more than 20 genes associated with lipodystrophy have been identified that may assist in diagnosis. Acquired lipodystrophies include, apart HIV-associated lipodystrophy, Lawrence syndrome, Barraquer-Simons syndrome and bone marrow transplant associated lipodystrophy. Because of its rarity and heterogeneity, lipodystrophy may frequently be unrecognized or misdiagnosed, which is concerning because it is progressive and its complications potentially life threatening. Effective management of lipodystrophy includes lifestyle changes and aggressive, evidence-based treatment of comorbidities. Leptin replacement therapy has been found to improve metabolic parameters, mainly in generalized lipodystrophy. In this presentation, it will be described the clinical features of known types of lipodystrophy, an algorithm for differential diagnosis of lipodystrophy subtypes, and suggest specific steps to recognize and diagnose lipodystrophy in the clinical setting.

Volume 56

20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

European Society of Endocrinology 

Browse other volumes

Article tools

My recent searches

No recent searches.

Authors