Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2018) 56 S21.3 | DOI: 10.1530/endoabs.56.S21.3

Poland.


Congenital adrenal hyperplasia (CAH) is defined as several autosomal recessive diseases resulting from mutations of genes for enzymes mediating the biochemical steps of production of mineralocorticoids, glucocorticoids or sex steroids from cholesterol by the adrenal glands. Fertility in women with CAH is essential and underestimated clinical problem. According to current studies patients with classic form of CAH due to 21-hydroxylase deficiency have lower fertility rate that correlate with the severity of mutation. It has complex background which is related to hormonal imbalance, surgery consequences psychological and sexual problems. Menstrual irregularities and anovulation occur frequently in CAH women affecting from 30 to 68% patients. Subfertility problems are milder in patients with nonclassic form of 21-hydroxylase deficiency. Some of these women conceive without treatment. Other women with anovulatory cycles respond to glucocorticoid alone or combined clomiphene citrate. Women with CAH present also higher risk of spontanous abortion than healthy women. Numerous studies reported that glucocorticoid treatment can lower the risk of spontanouse abortion. Males with CAH also may present impaired gonadal function and infertility.CAH patients with fertility problems should be consulted and properly treat.

Volume 56

20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

European Society of Endocrinology 

Browse other volumes

Article tools

My recent searches

No recent searches.

My recently viewed abstracts

Authors