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Belgian Endocrine Society 2018

BES 2018

Physiological relevance of LBD-dimerization of the androgen receptor

ea0057002 | Physiological relevance of LBD-dimerization of the androgen receptor | BES2018

Physiological relevance of LBD-dimerization of the androgen receptor

El Kharraz S , Helsen C , Hochepied T , Libert C , Houtsmuller A , Van Royen M , Vanderschueren D , Claessens F

Most mutations found in the androgen receptor (AR) are associated with some form of androgen insensitivity syndrome (AIS), and correlate with a loss of either hormone, DNA or coactivator binding. For some mutations in the ligand binding domain (LBD) of the AR, it is unclear what the underlying mechanism of the AIS could be. In the beginning of 2017, a new dimerization interface was uncovered in a crystal structure of the ligand-binding domain (LBD) which provides a possible me...