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Belgian Endocrine Society 2018

BES 2018

TAOK3 as a regulator of glucose tolerance in obesity

ea0057006 | TAOK3 as a regulator of glucose tolerance in obesity | BES2018

TAOK3 as a regulator of glucose tolerance in obesity

Maes B , Fayazpour F , Catrysse L , Lornet G , Lapauw B , Lambrecht BN , Janssens S

Aims or Objectives: We here describe a role for the kinase thousand and one kinase (TAOK) 3 as a modulator of insulin resistance. TAOK3 is one of three members of the TAOK family of kinases, which are classified within the Ste20-like kinases as mitogen activated protein kinase 4 kinases. TAOK3 was identified in a RNAi library screening in C. elegans as a target molecule that could revert an insulin resistance-like state induced by a daf-2 mutation (Devgen, Ghent). Mor...