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Belgian Endocrine Society 2018

BES 2018

Use of 3D culture systems to generate human induced pluripotent stem cell-derived β-cells in vitro

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GLP-1 analogs protect beta cells and prevent diabetes in models of Wolfram syndrome

ea0057003 | Use of 3D culture systems to generate human induced pluripotent stem cell-derived β-cells in vitro | BES2018

Use of 3D culture systems to generate human induced pluripotent stem cell-derived β-cells in vitro

Federica Fantuzzi , Sanna Toivonen , Alex Schiavo Andrea , Nathalie Pachera , Bahareh Rajaei , Ying Cai , Mariana Igoillo-Esteve , Eizirik Decio L , Miriam Cnop

Background and aims: Diabetes currently affects 425 million people worldwide. Pancreatic β-cell failure is central in the development and progression of type 1 and type 2 diabetes. Diabetes research is slowed by the difficulty to study the diseased tissue, i.e. human islet bcells: these are only available in a few donor organ transplantation centers worldwide. β-cells differentiated from human induced pluripotent stem cells (hiPSCs) represent a novel cell source. Cur...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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