Endocrine Abstracts

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Prader-Willi Syndrome (PWS) is a rare genetic disorder with a multitude of problems, often attributed to hypothalamic dysfunction. A child with PWS has a genetic predisposition to develop obesity due to appetite dysregulation, hyperphagia and excess calorie intake on the one hand; hypotonia, decreased muscle mass and decreased ability to spend the calories on the other hand. Although, there is no cure for PWS, lives of children with PWS can be significantly improved with speci...

Long bone fractures are common in childhood. However, recurrent fractures and certain types of fractures may indicate an underlying problem such as bone fragility. It is important to be able to identify those children who require closer evaluation and to consider how best to investigate such children. This should be done with an understanding of the likelihood and range of disease that may present with fractures, as well as the role of various modes of assessment. For those wi...

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Maintaining good diabetes control is essential to avoid long-term complications. NPDA data show that the percentage of children and young people achieving good control has increased year on year since 2011 and the percentage with very poor control (HbA1c >80 mmol/mol) has nearly halved in that time (28.7% in 2010-11, 16.4% in 2016-17). In Nottingham, we have managed to reduce the percentage of children and young people with very poor control from nearly 40% when we first s...

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