Gonadal

Background: Pubertal induction with incremental doses of oestrogen replacement is an important component of care offered to hypogonadal patients with Turner Syndrome (TS). Low dose oral ethinylestradiol (EE) has been extensively used in the UK but natural 17-β oestradiol (more physiological, cheaper and easily monitored in blood) is becoming increasingly popular. We undertook this audit to compare the efficacy and acceptability of oral (EE) and patch (Evorel) oestrogen pr...

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ea0058p014 | Gonadal | BSPED2018

Turners syndrome – clinical presentation, genetics, investigation and management: a 10 year review

Elechi Hassan Abdullahi , Law James , Alexander Jacqui , Denvir Louise , Randell Tabitha , Sachdev Pooja

Background: Turner syndrome (TS) is characterised by a wide phenotype and age at presentation. We reviewed our over-12s Turner clinic over a period of 10 years to evaluate pattern of diagnosis, co-morbidities and management.Subjects and method: Retrospective data analysis of patients with TS who attended the over-12s clinic (20082017, n=28). Data is median (IQR) or mean±SD as appropriate.Result: The age at diagn...

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ea0058p015 | Gonadal | BSPED2018

Abstract Unavailable....

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ea0058p016 | Gonadal | BSPED2018

A review of region-wide consultant knowledge of the management of disorders of sexual development (DSD)

Blackburn James , Sudarsanan Sunanda , Senniappan Senthil , Das Urmi , Blair Joanne , Alsaffar Hussain

Background: Disorders of sexual development (DSD) are estimated to occur in every 1 in 4500 births. This project builds upon previous work by the authors to explore the knowledge and management of paediatric junior doctors in a single deanery. The majority of junior doctors stated that they would seek the advice and explanation of paediatric consultant. We therefore attempted to qualify the knowledge and management strategies of the region-wide consultant body with regards to ...

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ea0058p017 | Gonadal | BSPED2018

Paediatric doctors’ experience and knowledge of the initial management of neonatal ambiguous genitalia

McGlacken-Byrne Sinead , Byrne Kathryn , O'Rahelly Mark , Ryan Ethel

Introduction: Neonatal ambiguous genitalia can herald sensitive, time-critical, and life-threatening diagnoses and thus paediatric doctors must be competent in their management. However, ambiguous genitalia are rare, limiting clinical exposure. We assessed paediatric doctors knowledge of and confidence in managing this condition.Methods: A questionnaire was circulated to paediatric doctors at six paediatric teaching hospitals. It established doctor...

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ea0058p018 | Gonadal | BSPED2018

XY-DSD due to haematological chimerism in twin pregnancy

Sakka Sophia , Arya Ved , Hall Richard , Holder Muriel

Introduction: Blood chimerism is the condition characterized by the presence of cells from at least 2 zygote lineages in only the lympho-hematopoietic system. It is very rare in humans and is most commonly seen in monozygotic monochorionic twins through placental anastomoses.Case report: A 12 years old young girl, one of dichorionic dizygotic twins, had a genetic test performed for paternity issues. CGH array showed 46XY genotype (90%) and another genoty...

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ea0058p019 | Gonadal | BSPED2018

Adolescents with HH: what outcome do they want from the gonadotropin stimulation process?

Monti Elena , Roberts Alice , Kleczewski Sara , Walton-Betancourth Sandra , Butler Gary

Background: Male adolescents with hypogonadotropic hypogonadism (HH) or delayed puberty start pubertal induction from 1214 years. Testosterone obtains secondarysexual characteristics and improves psychosocial well being. Gonadotropin releasing hormone (GnRH) or recombinant FSH (rFSH) and human chorionic gonadotropin (hCG) generate testicular growth (fertility) and testicular testosterone production. HCG-rFSH treatment increase testis size and improves the quality of life...

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Endocrine Abstracts

46th Meeting of the British Society for Paediatric Endocrinology and Diabetes

Poster Presentations

Pubertal induction among girls with turner syndrome: an audit of practice from 2008–2017

Turners syndrome – clinical presentation, genetics, investigation and management: a 10 year review

A review of region-wide consultant knowledge of the management of disorders of sexual development (DSD)

Paediatric doctors’ experience and knowledge of the initial management of neonatal ambiguous genitalia

XY-DSD due to haematological chimerism in twin pregnancy

Adolescents with HH: what outcome do they want from the gonadotropin stimulation process?

BiosciAbstracts