Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2018) 58 P010 | DOI: 10.1530/endoabs.58.P010

BSPED2018 Poster Presentations Bone (6 abstracts)

Changes in bone mineral density from age 10 to 30 years in individuals with cystic fibrosis

Thomas Bucknall 1 , Catrin Bucknall 2 , Camille Parsons 1 , Kate Ward 1 , Julian Legg 2 & Justin H Davies 3

1University of Southampton, Southampton, UK; 2University Hospital Southampton NHS Foundation Trust Southampton, UK; 3Paediatric Endocrinology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Background: Osteoporosis and increased fracture risk associated with cystic fibrosis (CF) are becoming more relevant with improved life expectancy in this disease. The evolution of CF-related bone disease remains unclear.

Aims: To evaluate change in bone mineral density (BMD) in individuals with CF from age 10 to 30 y.

Methods: Data from the UK CF Trust registry, which contains anonymised clinical information, was used to evaluate BMD at age 10, 18 and 30 y against the population mean. BMD z score was adjusted for size by including height z score in linear regressions. Association of BMD with lung function (FEV1%) was evaluated.

Results: Data was available for total body (TB) BMD at 10y n=62 (30 male) and 18 y n=78 (41 male); for lumbar spine (LS) BMD at 10y n=75 (37 male), 18 y n=148 (77 male), 30y n=133 (72 male). Mean TB BMD z scores at 10y and 18 y were −0.135 and −0.921 respectively. In a one-sample t test against the population mean, TB BMD z score was significantly different at 18 y (P<0.01) but not at 10 y. There was a significant relationship between BMD z score and FEV1% at 18 y (P<0.01) but not at 10 y. Mean LS BMD z score at 10 y, 18 y and 30 y were −0.167 (P>0.05), −0.958 (P<0.01) and −0.874 (P<0.01) respectively, P values representing significant difference to the population mean. There was a significant relationship between LS BMD z score and FEV1% at 18 y (P<0.01) and 30 y (P<0.05) but not at 10 y. For the TB BMD cohort, the percentage with a BMD z score of <−2 was 3.23% at 10 y and 25.6% at 18 y; for the LS BMD cohort, this was 2.67%, 20.3% and 21.8% at 10 y, 18 y and 30 y respectively.

Conclusions: There was a trend to decreasing BMD with increasing age in individuals with CF. A relationship between reduced FEV1% and reduced BMD was observed in adulthood. These results highlight the importance of monitoring BMDin CF.

Volume 58

46th Meeting of the British Society for Paediatric Endocrinology and Diabetes

Birmingham, UK
07 Nov 2018 - 09 Nov 2018

British Society for Paediatric Endocrinology and Diabetes 

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