Endocrine Abstracts

A 24 year old man presented with gait instability, myalgia, and cognitive decline, after a holiday in Crete; his alcohol intake exceeded 200 units/week. He had marked facial dysmorphism, with frontal bossing, and global muscle weakness. He had hypernatraemic dehydration (plasma sodium 175 mmol/l urea 16.9 mmol/l), but denied thirst. Urine concentration was 894 mOsm/kg, excluding diabetes insipidus. CK was elevated at 15,540 U/l. CT brain shown marked hydrocephalus. Rhabdomyoly...

Hyponatraemia is the most commonly recorded electrolyte abnormality occurring in 7% to 8% of elderly, ambulatory patients and 15 to 20% of hospitalized patients presenting a variety of symptoms ranging from very mild to life threatening. Correction of hyponatremia has been shown to improve the symptoms and signs associated with this condition. It is also recognized that excessively rapid correction of hyponatremia can be detrimental. During hospital admission, hyponatremia is ...

Background: Hyponatremia is a rare complication of pre eclampsia. We present a case of syndrome of inappropriate ADH secretion (SIADH) in the setting of pre eclampsia.Case Report: A 40 year old lady known to have type 1 diabetes on insulin pump therapy presented with hypertension at 33 weeks gestation. Treatment with labetalol 100 mg bd was initiated but she was admitted at 34 weeks due to lack of BP control. Sodium levels were 136 mmol/L (135–145 m...

Introduction: Diabetes Insipidus (DI) is the inability of the kidneys to concentrate urine. This is due to decreased production of Anti-diuretic Hormone (ADH) from the posterior pituitary gland (cranial DI) or decreased tubular sensitivity to ADH (nephrogenic DI) or a mixed picture.Case: A 53-year-old male presented with several-months history of polyuria and polydipsia. He had constant thirst and had to void urine four times at night. He did not have di...