Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2018) 59 P105 | DOI: 10.1530/endoabs.59.P105

1Endocrinology Medical Center, Minsk, Belarus; 2Belarusian State Medical Iniversity, Minsk, Belarus; 3RSPC ‘Cardiology’, Minsk, Belarus.


Materials and methods: Included patients were divided into … groups: group 1 – 41 almost healthy person (control group), group 2 – 59 patients with prediabetes, group 3 – 41 patients with T2D, group 4 – 40 patients with T2D and CHD and group 5 – 88 patients with CHD. Activities of glutathione peroxidase (GP, mmol/min) and glutathione reductase (GR, mmol/min) and concentrations of reduced glutathione (GSH, mmol/l), oxidized glutathione (GSSG, mmol/l) and redox-status (GSH/GSSG) were measured. A1c level was <7.5%, patients with anemia and acute cardiovascular diseases were excluded.

Results: Activities of GP, GR and concentrations of GSH, GSSG and redox-status of glutathione system presented in Table 1. GP activity was increased statistically significant in patients with T2D and T2D and CHD (P<0.05) and GR activity was increased in patients with CHD (P<0.05) compared to control group. Concentrations of GSH was decreased in groups 3,4, and 5 (P<0.05). But concentration of GSSG was significantly higher only in patients with T2D and CHD. Also CHD was associated with depression of redox-status with maximum decrease when T2D is associated with CHD.

Conclusion: T2D was associated with increased activity of GP. Decreased concentration of GSSG, increased concentration of GSH and depressed redox-status of glutathione system can be used as additional markers for early prognosis of atherosclerosis development in patients with impaired carbohydrate metabolism.

Table 1
FindingsGroup 1Group 2Group 3Group 4Group 5
GP44.38 (34.14;55.73)44.97 (36.96;58.70)51.01 (31,36;67,52)60.13 (50,25;70,12)45.58 (36.73;52.32
GR0.98 (0.76;1.09)0.89 (0.69;1.10)0.84 (0.76;1.18)1.12 (0,81;1,28)1.47 (1.32;1.88)
GSH2.53 (2.29;3.15)2.14 (1.98;4.19)2.08 (2.00;2.92)1.34 (0.61;1.41)1,47 (1.32;1.88)
GSSG0,36 (0.34;0.38)0,33 (0.31;0.36)0,31 (0.30;0.32)0.40 (0.36;0.40)0.36 (0.33;0.38)
GSH/GSSG7.03 (6.73;8.29)6.48 (6.38;11.64)6.70 (6.67;9.12)3.35 (1.69;3.53)4.08 (4.00;4.95)

Volume 59

Society for Endocrinology BES 2018

Glasgow, UK
19 Nov 2018 - 21 Nov 2018

Society for Endocrinology 

Browse other volumes

Article tools

My recent searches

No recent searches.

My recently viewed abstracts