Endocrine Abstracts

Nuclear receptors regulate many developmental processes and a vast array of physiological responses. They control the expression of subsets of specific genes by recruiting co-factors that can function either as co-activators or co-repressors to either stimulate or repress gene transcription. Using the ligand-binding domain of the estrogen receptor as bait we identified a receptor interacting protein of MW 140Kd that we called RIP140. Examination of RIP140 null mice showed two ...