Endocrine Abstracts

Primary adrenal insufficiency (AI) is often a consequence of autoimmune destruction of the adrenal cortex, but a number of other causes have been reported, including genetic diseases, haemorrhage, infections, infiltration by tumour or metastasis, and medication. AI is rare with reported prevalence at 10–20 per 100 000 inhabitants. Before replacement therapy with corticosteroids became available, AD was invariably fatal. Accessibility to hydrocortisone and fludrocortisone ...

Adrenal masses are discovered in 5% of abdominal imaging scans and the diagnostic work-up has to address two major questions: does the adrenal mass overproduce hormones and, most important to the patient, does the adrenal tumour represent cancer? The reported incidence of adrenocortical carcinoma varies in reported series from 2 to 11%. However, the accuracy of currently available imaging tests to diagnose malignancy is poor. Urine steroid metabolomics is a combination of ster...

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