Endocrine Abstracts

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Obesity prevalence is increasing across the globe. This includes women of childbearing age with recent statistics reporting that over half of women are now either overweight or obese during pregnancy in the UK. This is accompanied by an increased prevalence of gestational diabetes with some reports suggesting that one in seven babies in the world are born from a diabetic pregnancy. This is a major concern as evidence from humans and animal models suggests that developing in ut...

Early-life stress (ES) is associated with increased vulnerability to cognitive impairments as well as metabolic disorders like obesity later in life. We investigate the role of a synergistic effect of stress, metabolic factors, nutrition and the neuroimmune system in this early-life induced programming. We use an established model of chronic ES and expose mice to limited nesting and bedding material during first postnatal week and study the central and peripheral systems under...