ea0061cd2.3 | Case Discussions: complex clinical cases 2.0 | OU2019
, Burke Bernard
, Mee Christopher
, Renshaw Derek
Introduction: Adipose tissue oxygen consumption and blood flow are altered in obesity inducing local tissue hypoxia. Hypoxia affects several biological functions including adipogenesis, inflammation, insulin resistance and metabolism affecting the overall degree of adiposity. The expression of Annexin A1 (ANXA1); an anti-inflammatory protein, increases in the adipose tissue in response to obesity and further increases in the subcutaneous adipose tissue of old obese individuals...