Searchable abstracts of presentations at key conferences in endocrinology
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Obesity Update 2019

Oral Communications

Case Discussions: complex clinical cases 2.0

ea0061cd2.1 | Case Discussions: complex clinical cases 2.0 | OU2019

Factors related to Non-Alcoholic Fatty Liver Disease (NAFLD) measures in obese subjects with early Type 2 Diabetes mellitus

Zaghloul Hadeel , Chagoury Odette , McGowan Barbara , Taheri Shahrad , DIADEM-1 Study Team Shahrad

Introduction: T2DM (type 2 diabetes mellitus) appears to worsen the course of NAFLD (Non-Alcoholic Fatty Liver Disease) and NAFLD can make diabetes management more challenging. Long-term, NAFLD can lead to liver fibrosis, steatohepatitis, cirrhosis, and end-stage liver disease. This study aimed to examine factors associated with NAFLD measures in early T2DM.Methods: Subjects (n=144) with early T2DM (<=3 years) and obesity (BMI>=27 kg/m<s...

ea0061cd2.2 | Case Discussions: complex clinical cases 2.0 | OU2019

Simultaneous islet cell and kidney transplant in a patient with Type 1 Diabetes and End-Stage Renal Failure after Roux-en-Y gastric bypass

Lim Jonathan ZM , Rutter Martin K , Wilding John PH

Background: Severe obesity, BMI ≥40 kg/m2, confers a greater risk for graft loss and mortality among renal transplant patients. Transplantation provides a better survival and quality of life in overweight dialysis patients. Higher BMI is associated with progressively increased risk of CKD stages 4–5, hazard ratio of 3.10 (CI 2.95–3.25) for BMI ≥35 kg/m2. A recent meta-analysis found pre-transplant BMI <30 kg/m2 is asso...

ea0061cd2.3 | Case Discussions: complex clinical cases 2.0 | OU2019

Exploring the roles of Annexin A1 in adipocytes using an in vitro model of obesity

Sajid Sehar , Burke Bernard , Mee Christopher , Renshaw Derek

Introduction: Adipose tissue oxygen consumption and blood flow are altered in obesity inducing local tissue hypoxia. Hypoxia affects several biological functions including adipogenesis, inflammation, insulin resistance and metabolism affecting the overall degree of adiposity. The expression of Annexin A1 (ANXA1); an anti-inflammatory protein, increases in the adipose tissue in response to obesity and further increases in the subcutaneous adipose tissue of old obese individuals...