Endocrine Abstracts

Introduction: Steatosis has become an important issue in hepatitis C, due to the injury it can cause in a chronically ill liver. In chronic hepatitis C patients, the prevalence of steatosis ranges from 40–86%. Steatosis was significantly associated with the lack of response using PEG-IFN and ribavirin. The aim of our study was to determine the prevalence of hepatic steatosis in chronic hepatitis C and determine its impact on the therapeutic response using new direct antiv...

Introduction: Acromegaly is a rare chronic, and disfiguring endocrine disorder characterized by growth hormone excess, that carries a significant burden of cardiovascular morbidity and mortality; and still unfortunately one of the most important cause of death in acromegaly. The purpose of this study is to describe the cardiovascular events and risk factors concerning patients with acromegaly who are followed up in the endocrinology department of Oujda’s Mohammed VI unive...

Introduction: Thomsen’s disease is a non-dystrophic congenital myotonia with autosomal dominant inheritance. Its association with short stature attributed to growth hormone deficiency (GHD) has never been reported in literature to our best knowledge.Case report: A 14-years-old Moroccan boy, with no particular medical history, presented for evaluation of a short stature. On physical examination, the patient had a height of 141 cm (−2.5 S...

Introduction: Premature pubarche is defined as early appearance of pubic or axillary hair without any other signs of puberty, before 8 years of age in girls and 9 years in boys. We present the case of a 6 months old boy who came to us with scrotal hair since birth with moderate progression until present.Case presentation: A 6 months old male patient was referred to our clinic to investigate the presence of thick scrotal hair, affirmatively present at bir...

Background: Diets rich in polyunsaturated fatty acids (PUFA) n-3 may change the fluidity and composition of membrane phospholipids, leading to different prostanoids formation, decreasing IL-1β and TNFα releases and increasing the basal levels of corticosterone, important factors to promote acute phase response (APR) to stimuli. This study proposes to verify if PUFA n-3 or n-6 rich diets alters the APR of fibrinogen and haptoglobin after turpentine stimulus.<p cla...

Actuality: Diabetes is one of the largest global health emergencies of the 21st century. Each year more and more people live with this condition, which can result in life-changing complications. In addition to the 415 million adults who are estimated to currently have diabetes, there are 318 million adults with impaired glucose tolerance, which puts them at high risk of developing the disease in the future (International Diabetes Federation, 2015). The prevalence of patients w...

Introduction: Hidradenitis suppurativa (HS), also known as acne in-versa is a chronic inflammato-ry dermatosis. Emerging evidence suggests that HS is associated with other comorbidities, while data concerning the coexistence of HS and Down syndrome (DS) are scarce. We report the case of a young male affected by DS and HS that suffers from multiple endocrine disturbances.Observation: A 23-year-old overweight male (BMI 32 kg/m2) with a 9-year hi...

Introduction: Rothmund-Thomson syndrome (RTS) is a rare autosomal recessive genodermatosis, with specific clinical features. Herein, we report a case of RTS with RECQL4 mutation, unusually associated with hypercortisolemia.Case report: An 18-year-old girl, born to consanguinous parents, with a history of xeroderma pigmentosum (XP) in two cousins, has been followed-up for RTS, since the age of 3 years. The diagnosis of RTS was made based on photosensitivi...

Introduction: When hypoglycemia is deep and repeated, it can induce various neurological disorders, including epileptic seizures. The link between hypoglycemia and epileptic phenomena is complex and poorly explained. We report 3 cases of epilepsy induced by repeated episodes of deep hypoglycemia.Cases report: Mr D.M, 48 years old, with a history of 3 episodes of hypoglycemic coma, admitted for status epilepticus with a blood glucose level of 0.4 g /l; ce...

Rationale and objectives: Validation of new therapeutic regimens in the treatment of hypertension, particularly in poorly controlled patients at high risk for cardiovascular disease, is urgently needed. We evaluated the efficacy and safety of two doses of the candesartan cilexetil/hydrochlorothiazide combination (Blopress Plus®) in hypertensive patients in Jordan.Methods: An observational, multicenter, prospective, open-label study of Jor...

Introduction: Hyperprolactinemia may be physiological or caused by discontinuation of normal prolactin regulation because of certain drugs or by other diseases such as kidney, ovarian and thyroid diseases.Materials and methods: This is a retrospective study of 30 patients presenting with hyperprolactinemia.Results: The average age was 30 years old. 20 patients married, 10 no married (30%). The indication of the prolactin dosage was...

Issues: No specific centre in asia for Osteoporosis patients treatment/rehabilitation. We used locally available Complementary Indian Medicines [CAM] for providing home based care in rural/tribal areas.Aims: To provide CAM to poor patients in collaboration with Traditional-faith-hearers. Evaluated cost-efficacy of CAM & response of pain of fractures to CAM alongside analgesics.Methods: This was a cross sectional, observational ...