Endocrine Abstracts

Background: Non-alcoholic fatty liver disease (NAFLD) is considered most common cause of end stage Liver disorder that needs liver transplantation worldwide. NAFLD is considered the hepatic aspect of metabolic syndrome. The association between thyroid dysfunction and NAFLD has increasingly become interesting focus of research.Objective: Evaluation of thyroid function in obese adults with non-alcoholic fatty liver disease attending at Tan...

Introduction: Thyrotoxicosis syndrome is a clinical syndrome, associated with the negative effect of strong thyroid hormone excess on the organism. In most cases women with thyrotoxicosis syndrome in postpartum period have postpartum thyroiditis, caused by reactivation of the immune system after gestational suppression. However sometimes Graves disease can manifest during the postpartum period, this condition also results in thyrotoxicosis syndrome and requires radical thyroid...

Introduction: Hypothyroidism is not a common cause of renal failure which remains under-appreciated. Herein we report a case of acute renal failure in a patient with a severe primary hypothyroidism in whom hormone replacement therapy with Levothyroxine has significantly improved renal function.Observation: A 72-year-old man was referred to our department for primary hypothyroidism. His past medical history included a coronary heart disease with a heart f...

Introduction: Since the thyroid myxedema coma is rarely seen nowadays, its diagnosis can be overlooked.Case: The patient with tracheostomy who underwent total laryngectomy and bilateral neck dissection and radiotherapy (RT) at the neck region 10 years ago due to Larynx cancer was admitted to the intensive care unit the diagnosis periorbital edema, hypotension, hypothermia, consciousness disorder and pneumosepsis. Treatment was started for Acinobacter, wh...

Autoimmune thyroid disease is the common autoimmune disorders. It is more commonly in women. 2% to 4% of women and up to 1% of men are affected worldwide The prevalence increases with advancing age. Detection and quantification of the antibody titers help in establishing an autoimmune etiology.Objectives: We study the prevalence of thyroid hormone dysfunction especially TSH and positive anti-TPO antibody titers in patients suspect for thyroid-related dis...

Hyperthyroidism is rarely associated with malignancy. Some cases of co-existing between hyperthyroidism and thyroid carcinoma have been described. We report a case of association of a toxic thyroid nodule and papillary microcarcinoma.Observation: A 50-year-old male was referred to the endocrinologist for hyperthyroidism (TSH: 0.01 mUI/l, FT4: 22.8 pmol/l, FT3: 17.1 pmol/l). Thyroid ultrasonography showed a nodule of 38 mm in the left lobe. 99 mTc thyroid...

Introduction: Primary lymphoma of the thyroid (PTL) is a rare cause of malignancy, accounting for 5% of thyroid malignancies, with an annual estimated incidence of 2 per 1 million. Women are more commonly affected than men (2–8:1). Patients typically present in the sixth or seventh decade of life. Most thyroid lymphomas are non-Hodgkin’s lymphomas (NHLs) of B-cell origin. Patients with Hashimoto’s thyroiditis are at greater risk for developing PTL. Treatment and...

Introduction: Lymphoma of the thyroid gland is an uncommon condition occurring primarily in older women. Most patients have a short history of enlarging thyroid or a neck mass causing tracheal compression. There is also a strong association between thyroid lymphoma and Hashimoto’s thyroiditis. The diagnosis is established by biopsy. The conventional approach to treatment is combination of radiation therapy with multi-agent chemotherapy, while there is no significant role ...

Background: Chronic spontaneous urticaria (CSU) is defined by the presence of recurrent urticaria (also called hives or wheals), angioedema, or both, for a period of six weeks or longer. CSU affects just 1% pf the general population and its etiopathogenesis is not well understood. CSU is known to be associated with various autoimmune conditions. However the association CSU and Graves Disease is very rarely seen in clinical practice.Clinical case: In this...

The aim: Is to investigate the effectiveness of therapy with testosterone undecanoatein patients with hypothyroidism and androgen deficiency.Material and methods: Substitution therapy with testosterone was performed on 55 men with hypothyroidism and clinically or laboratory confirmed androgen deficiency. The age of the patients was from 35 to 69 years, the duration of hypothyroidism – from 3 to 16 years.Results: The average to...

Background: İt is known that there is a relationship between some diseases and blood groups.Objective: The objective of our study is to investigate how often ABO and Rh blood groups are seen in benign thyroid diseases, especially in autoimmune-mediated thyroid diseases, and hence whether there is an association between blood groups and thyroid diseases.Method: A total of 958 patients who were followed due to any benign thyroi...

Hashimoto’s thyroiditis (HT) is the most common inflammatory condition of the thyroid gland. In addition to the classic variant of HT, several other subtypes have been identified, such as the fibrous variant (HTFV).Case history: A 38 years old man noticed a rapidly enlarging lump in his neck month ago. This resulted in discomfort with choking sensation and mild dysphagia. He mentioned weight loss, tiredness and night sweats. He was a smoker and dran...

Introduction: Asymptomatic, mild or moderate elevations of creatine phosphokinase are frequently found in hypothyroidism, but rhabdomyolysis is rare, and even more so when it constitutes its clinical presentation.Clinical case: A 26-year-old male who regularly practiced sports, with no family or personal history of interest, went to the emergency room referring to myalgia, generalized cramps, and muscular weakness in the previous two weeks which had not ...

Introduction: Primary thyroid lymphomas are rare (2–5% of thyroid cancers and less than 5% of extra-ganglionic lymphomas). The most frequent types are B-cell lymphoma and MALT lymphoma. Posing a diagnosis problem, including differential diagnosis with anaplastic cancer. We report two different cases of thyroid lymphoma.Observation: Case 1: Women 64-year-old, followed by 7 years for Hashimoto’s thyroid consulted for a cervical mass, of rapid evo...

Langherhans cell histiocytosis (LCH) and Erdheim-Chester (EC) are two histiocytic disorders which occurrence in the same patient has rarely been described. Thyroid involvement of LCH is rare, and concurrent papillary thyroid carcinoma (PTC) exceptionally reported. We report a case of a 73 year old man who presented a diagnosis of mixed histiocytosis LCH and EC. The patient suffered of insipidus diabetes since 1 year without pituitary abnormality but clinical examination showed...

Introduction: Papillary thyroid carcinoma (PTC) is a differentiated thyroid carcinoma accounting for approximately 80% of all thyroid malignancies; in contrast only 1–2% of thyroid cancers are anaplastic. While the transformation of papillary thyroid carcinoma to the more aggressive anaplastic carcinoma represents a well known occurrence, the transformation of metastatic PTC in a distant location is an uncommon finding, but new insights from the BRAF(V600E) mutat...

Introduction: Detection of TSH-receptor autoantibodies in the diagnosis of graves disease is well established. however these autoantibodies may not be always present in some forms of correctly observed autoimmune hyperthyroidism. Here, we describe a patient with hyperthyroid Graves’ disease without detectable thyrotropin receptor antibodies.Case report: She was A 55-year-old woman, presented with a 2 years history of increased sweating, palpitations...

Introduction: Graves’ disease represents an autoimmune disease of the thyroid gland, which therapeutic management is controversy. The aim of our study is to discuss, after a review of the literature, the role of surgery, especially total thyroidectomy, in the treatment of Graves’ disease.Patients and methods: We conducted a retrospective study of medical records of 39 patients who underwent surgery for Graves’ disease at the Department of ...

Introduction: A disturbed thyroid status is a frequent reason for consultation in endocrinology. The typical tables of hypo or hyperthyroidism encountered lead to classical etiological investigations whether central or peripheral. In some unusual situations, the profile encountered may be atypical. We report a case.Observation: Six years old girl, hospitalized for a goitre evolving since one year without thyrotoxicosis nor compression signs. There was st...

Serum CA 19-9 (carbohydrate antigen 19-9) is a tumor marker of monosialoganglioside structure. Its level is frequently measured for screening purposes in daily practice by physicians, while its main use is in the study of tumor recurrence and follow-up of recurrences. Although significant elevations in CA 19-9 levels cause suspicion of malignancy, an underlying malignant disease may not always be determined and benign pathologies may also be seen. A 45-year-old female patient ...

Gynecomastia is an uncommon clinical manifestation of hyperthyroidism, due to an imbalance between sexual hormones caused by thyroid hormones excess. Recognition of such unusual association is important to ensure appropriate treatment and to avoid unnecessary investigation. In hyperthyroidism, increased serum levels of SHBG binds testosterone with greater affinity than estradiol, resulting in relatively higher free estradiol compared with free testosterone levels and thereby c...

Thyrotoxicosis is characterised by the excess of thyroid hormones into blood. The most extreme appearance of it, is thyroid storm which is presented as an acute, severe, life-threatening, hypermetabolic state caused by the added quantities of thyroid hormones, causing adrenergic hyperactivity and abnormal periphery response of thyroid hormones. The incidence of thyroid storm is evaluated at 0.2/100000 in year. The mortality of untreated thyroid storm varies from 80–100% w...

Introduction: At present patients and relatives garner more knowledge through website rather than direct interaction with the Consultant physician. We aimed at assessing whether Indian website about Endocrine Surgery matched with their counterpart abroad.Materials and methods: We identified two most searched Endocrine Surgery website world wide and 10 endocrine surgerywebsite maintained by trained Endocrine Surgeons (three years training leading to award...