Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2019) 63 GP211 | DOI: 10.1530/endoabs.63.GP211

ECE2019 Guided Posters Diabetes: Pharmacotherapy (12 abstracts)

New insights on strain-specific impacts of probiotics on insulin resistance

Nazarii Kobyliak 1 , Tetyana Falalyeyeva 2 , Olena Tsyryuk 2 & Liudmyla Ostapchenko 2


1Bogomolets National Medical University, Kyiv, Ukraine; 2Taras Shevchenko National University of Kyiv, Kyiv, Ukraine.


Background and aims: Comparative animal study of efficacy of intermittent short courses administration of lyophilized single-, three- and alive multistrain probiotic on insulin resistance in rats with experimental obesity.

Methods: We included 70 rats divided into 7 groups (n=10 in each). Rats of group I were intact. Newborn rats of groups II-VII were injected with monosodium glutamate (MSG) (4 mg/g). Rats of group II (MSG-obesity group) were untreated. The groups III-V received lyophilized mono-probiotics B.animalis VKL, B.animalis VKB, L.casei IMVB−7280 respectively. The group VI received the mix of these three probiotic strains. The group VII was treated with multi-probiotic ‘Symbiter’ which contains 14 alive probiotic strains (Lactobacillus, Bifidobacterium, Propionibacterium, Acetobacter genera).

Results: Neonatal treatment with MSG lead to the development of obesity in all MSG-obesity rats and up to 20–70% after probiotic administration. Supplementation of probiotic composition, with preference to alive strains (group VII), led to a significantly lower prevalence of obesity, decreasing of HOMA-IR (2.31±0.13 vs 3.07±0.3; P<0.001), proinflammatory cytokines levels (IL-1β, IL-12Bp40) and elevation of adiponectin (5.67±0.39 vs 2.27±0.36; P<0.001) as compared to MSG-obesity. Furthermore, significant changes were absent between alive probiotic group (VII) and intact rats (P=0.098). Single-strain analysis (group III-V) shows significant decreasing of metabolic parameters, but changes were less pronounced as compared to mixture groups and did not achieved intact rats level.

Conclusion: Multistrain formed mutualistic interactions in mixtures and therefore able to share with different metabolites, affect different receptors, which synergistic overall effect greater than the sum of the single effects.

Volume 63

21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

European Society of Endocrinology 

Browse other volumes

Article tools

My recent searches

No recent searches.